Influence of the loop size and nucleotide composition on AgoshRNA biogenesis and activity



Short hairpin RNAs (shRNAs) are widely used for gene silencing by the RNA interference (RNAi) mechanism. The shRNA precursor is processed by the Dicer enzyme into active small interfering RNAs (siRNAs) that subsequently target a complementary mRNA for c...
Date made available2017
PublisherTaylor & Francis

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