The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors

  • Mahnoush Bahjat (Creator)
  • Guus de Wilde (Creator)
  • Tijmen van Dam (Creator)
  • Chiel Maas (Creator)
  • Timon Bloedjes (Creator)
  • Richard J. Bende (Creator)
  • Carel J.M. van Noesel (Creator)
  • Dieuwertje M. Luijks (Creator)
  • Eric Eldering (Creator)
  • Marie J. Kersten (Creator)
  • Jeroen E. J. Guikema (Creator)

Dataset

Description

The BCR-ABL1 fusion gene is the driver oncogene in chronic myeloid leukemia (CML) and Philadelphia-chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). The introduction of tyrosine kinase inhibitors (TKIs) targeting the ABL kinase (such as imat...
Date made available2019
PublisherTaylor & Francis

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