Amsterdam Neuroscience - Complex Trait Genetics (VUmc)

Research output

Research output per year 1995 2017 2021 2022 2023 2024

• 838 Article
• 47 Comment/Letter to the editor
• 46 Review article
• 40 Meeting Abstract
• 56 More
  • 18 Letter
  • 14 Erratum/Corrigendum
  • 13 Phd-Thesis - Research and graduation internal
  • 7 Chapter
  • 4 Editorial

Research output per year

Research output per year

Search results

• 2002

  The pathological cascade of Alzheimer's disease: The role of inflammation and its therapeutic implications

  Hoozemans, J. J. M., Veerhuis, R., Rozemuller, A. J. M. & Eikelenboom, P., Jun 2002, In: Drugs of today (Barcelona, Spain). 38, 6, p. 429-443

  Research output: Contribution to journal › Review article › Academic › peer-review
  33 Citations (Scopus)
• 2005

  Genotypic and phenotypic characterization of Noonan syndrome: New data and review of the literature

  Jongmans, M., Sistermans, E. A., Rikken, A., Nillesen, W. M., Tamminga, R., Patton, M., Maier, E. M., Tartaglia, M., Noordam, K. & Van Der Burgt, I., 15 Apr 2005, In: American journal of medical genetics. 134 A, 2, p. 165-170 6 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  100 Citations (Scopus)
• 2006

  Detecting genotype-environment interaction in monozygotic twin data: Comparing the Jinks and Fulker test and a new test based on marginal maximum likelihood estimation

  Van Der Sluis, S., Dolan, C. V., Neale, M. C., Boomsma, D. I. & Posthuma, D., 1 Jun 2006, In: Twin research and human genetics. 9, 3, p. 377-392 16 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  23 Citations (Scopus)

• Stress, depression and hippocampal apoptosis

  Lucassen, P. J., Heine, V. M., Muller, M. B., van der Beek, E. M., Wiegant, V. M., De Kloet, E. R., Joels, M., Fuchs, E., Swaab, D. F. & Czeh, B., Oct 2006, In: CNS and Neurological Disorders. Drug Targets. 5, 5, p. 531-46 16 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  208 Citations (Scopus)
• 2014

  Expanding the spectrum of phenotypes associated with germline PIGA mutations: a child with developmental delay, accelerated linear growth, facial dysmorphisms, elevated alkaline phosphatase, and progressive CNS abnormalities

  van der Crabben, S. N., Harakalova, M., Brilstra, E. H., van Berkestijn, F. M. C., Hofstede, F. C., van Vught, A. J., Cuppen, E., Kloosterman, W., Ploos van Amstel, H. K., van Haaften, G. & van Haelst, M. M., Jan 2014, In: American Journal of Medical Genetics Part A. 164A, 1, p. 29-35 7 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  36 Citations (Scopus)
• 2016

  Mandibulofacial Dysostosis with Microcephaly: Mutation and Database Update

  Care4Rare Canada Consortium & UCLA Clinical Genomics Center, 1 Feb 2016, In: Human mutation. 37, 2, p. 148-154 7 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  43 Citations (Scopus)

• Modeling psychiatric disorders: From genomic findings to cellular phenotypes

  Falk, A., Heine, V. M., Harwood, A. J., Sullivan, P. F., Peitz, M., Brüstle, O., Shen, S., Sun, Y. M., Glover, J. C., Posthuma, D. & Djurovic, S., 1 Sept 2016, In: Molecular psychiatry. 21, 9, p. 1167-1179 13 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  64 Citations (Scopus)
• 2017

  Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals

  Rivera, M., Locke, A. E., Corre, T., Czamara, D., Wolf, C., Ching-Lopez, A., Milaneschi, Y., Kloiber, S., Cohen-Woods, S., Rucker, J., Aitchison, K. J., Bergmann, S., Boomsma, D. I., Craddock, N., Gill, M., Holsboer, F., Hottenga, J-J., Korszun, A., Kutalik, Z., Lucae, S., & 19 othersMaier, W., Mors, O., Müller-Myhsok, B., Owen, M. J., Penninx, B. W. J. H., Preisig, M., Rice, J. P., Rietschel, M., Tozzi, F., Uher, R., Vollenweider, P., Waeber, G., Willemsen, G., Craig, I. W., Farmer, A. E., Lewis, C. M., Breen, G., McGuffin, P. & Mueller-Myhsok, B., Aug 2017, In: British journal of psychiatry. 211, 2, p. 70-76 7 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  46 Citations (Scopus)

• Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms

  van der Knaap, M. S. & Bugiani, M., 1 Sept 2017, In: Acta Neuropathologica. 134, 3, p. 351-382 32 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  214 Citations (Scopus)
• 2018

  The Biological Contributions to Gender Identity and Gender Diversity: Bringing Data to the Table

  on behalf of the International Gender Diversity Genomics Consortium, 1 Mar 2018, In: Behavior genetics. 48, 2, p. 95-108 14 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  91 Citations (Scopus)

• The Healthy and Diseased Microenvironments Regulate Oligodendrocyte Properties: Implications for Regenerative Medicine: Implications for Regenerative Medicine

  Leferink, P. S. & Heine, V. M., 1 Jan 2018, In: American journal of pathology. 188, 1, p. 39-52 14 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  9 Citations (Scopus)

• The impact of chronic stress during adolescence on the development of aggressive behavior: A systematic review on the role of the dopaminergic system in rodents: A systematic review on the role of the dopaminergic system in rodents

  Tielbeek, J. J., Al-Itejawi, Z., Zijlmans, J., Polderman, T. J. C., Buckholtz, J. W. & Popma, A., 1 Aug 2018, In: Neuroscience and Biobehavioral Reviews. 91, p. 187-197 11 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  23 Citations (Scopus)
• 2019

  A comprehensive diagnostic approach to detect underlying causes of obesity in adults

  van der Valk, E. S., van den Akker, E. L. T., Savas, M., Kleinendorst, L., Visser, J. A., Van Haelst, M. M., Sharma, A. M. & van Rossum, E. F. C., 1 Jun 2019, In: Obesity Reviews. 20, 6, p. 795-804 10 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  50 Citations (Scopus)

• Genetic correlations of polygenic disease traits: from theory to practice

  van Rheenen, W., Peyrot, W. J., Schork, A. J., Lee, S. H. & Wray, N. R., 1 Oct 2019, In: Nature Reviews Genetics. 20, 10, p. 567-581 15 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  165 Citations (Scopus)

• Genetics of Obesity

  Kleinendorst, L., van Haelst, M. M. & van den Akker, E. L. T., 1 Jan 2019, In: Experientia supplementum (2012). 111, p. 419-441 23 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  7 Citations (Scopus)

• The importance of reliable quality control materials for noninvasive prenatal testing

  Sistermans, E. A., 2019, In: Clinical Chemistry. 65, 6, p. 720-722

  Research output: Contribution to journal › Review article › Academic › peer-review
  1 Citation (Scopus)
• 2020

  Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders

  Vos, N., Oussaada, S. M., Cooiman, M. I., Kleinendorst, L., ter Horst, K. W., Hazebroek, E. J., Romijn, J. A., Serlie, M. J., Mannens, M. M. A. M. & van Haelst, M. M., 1 Sept 2020, In: Current Diabetes Reports. 20, 9, 44.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  18 Citations (Scopus)

• Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD: a powerful tool for iPSC-based modelling of ASD

  Drakulic, D., Djurovic, S., Syed, Y. A., Trattaro, S., Caporale, N., Falk, A., Ofir, R., Heine, V. M., Chawner, S. J. R. A., Rodriguez-Moreno, A., van den Bree, M. B. M., Testa, G., Petrakis, S. & Harwood, A. J., 1 Jun 2020, In: Molecular autism. 11, 1, p. 42 1 p., 42.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  12 Citations (Scopus)
• 2021

  Alzheimer's disease

  Scheltens, P., de Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C. E., Cummings, J. & van der Flier, W. M., 24 Apr 2021, In: The Lancet. 397, 10284, p. 1577-1590 14 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  1461 Citations (Scopus)

• Changes in peripheral blood compounds following psychopharmacological treatment in drug-naïve first-episode patients with either schizophrenia or major depressive disorder: A meta-analysis

  Çakici, N., Sutterland, A. L., Penninx, B. W. J. H., De Haan, L. & Van Beveren, N. J. M., Mar 2021, In: Psychological Medicine. 51, 4, p. 538-549 12 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  16 Citations (Scopus)

• Childhood onset nexilin dilated cardiomyopathy: A heterozygous and a homozygous case

  Bruyndonckx, L., Vogelzang, J. L., Bugiani, M., Straver, B., Kuipers, I. M., Onland, W., Nannenberg, E. A., Clur, S-A. & van der Crabben, S. N., Aug 2021, In: American Journal of Medical Genetics Part A. 185, 8, p. 2464-2470 7 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

• Childhood Trauma in Adult Depressive and Anxiety Disorders: An Integrated Review on Psychological and Biological Mechanisms in the NESDA Cohort

  Kuzminskaite, E., Penninx, B. W. J. H., van Harmelen, A-L., Elzinga, B. M., Hovens, J. G. F. M. & Vinkers, C. H., 15 Mar 2021, In: Journal of affective disorders. 283, p. 179-191 13 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  53 Citations (Scopus)

• Depressive and anxiety disorders in concert–A synthesis of findings on comorbidity in the NESDA study

  ter Meulen, W. G., Draisma, S., van Hemert, A. M., Schoevers, R. A., Kupka, R. W., Beekman, A. T. F. & Penninx, B. W. J. H., 1 Apr 2021, In: Journal of affective disorders. 284, p. 85-97 13 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  44 Citations (Scopus)

• Diet, obesity, and depression: A systematic review

  Patsalos, O., Keeler, J., Schmidt, U., Penninx, B. W. J. H., Young, A. H. & Himmerich, H., Mar 2021, In: Journal of personalized medicine. 11, 3, p. 1-19 19 p., 176.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  49 Citations (Scopus)

• Drug Repurposing for Rare Diseases

  Roessler, H. I., Knoers, N. V. A. M., van Haelst, M. M. & van Haaften, G., Apr 2021, In: Trends in pharmacological sciences. 42, 4, p. 255-267 13 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  93 Citations (Scopus)

• Emerging Methods and Resources for Biological Interrogation of Neuropsychiatric Polygenic Signal

  Uffelmann, E. & Posthuma, D., 1 Jan 2021, In: Biological Psychiatry. 89, 1, p. 41-53 13 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  33 Citations (Scopus)

• Pathophysiology of respiratory failure in patients with osteogenesis imperfecta: a systematic review

  Storoni, S., Treurniet, S., Micha, D., Celli, M., Bugiani, M., van den Aardweg, J. G. & Eekhoff, E. M. W., 2021, In: Annals of Medicine. 53, 1, p. 1676-1687 12 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  17 Citations (Scopus)

• Prevalence, course, and determinants of suicide ideation and attempts in patients with a depressive and/or anxiety disorder: A review of NESDA findings

  Wiebenga, J. X. M., Dickhoff, J., Mérelle, S. Y. M., Eikelenboom, M., Heering, H. D., Gilissen, R., van Oppen, P. & Penninx, B. W. J. H., 15 Mar 2021, In: Journal of affective disorders. 283, p. 267-277 11 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  34 Citations (Scopus)

• Systematic Review: How the Attention-Deficit/Hyperactivity Disorder Polygenic Risk Score Adds to Our Understanding of ADHD and Associated Traits

  Ronald, A., de Bode, N. & Polderman, T. J. C., 1 Oct 2021, In: Journal of the American Academy of Child and Adolescent Psychiatry. 60, 10, p. 1234-1277 44 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  53 Citations (Scopus)
• 2022

  A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

  Sforzini, L., Worrell, C., Kose, M., Anderson, I. M., Aouizerate, B., Arolt, V., Bauer, M., Baune, B. T., Blier, P., Cleare, A. J., Cowen, P. J., Dinan, T. G., Fagiolini, A., Ferrier, I. N., Hegerl, U., Krystal, A. D., Leboyer, M., McAllister-Williams, R. H., McIntyre, R. S., Meyer-Lindenberg, A., & 41 othersMiller, A. H., Nemeroff, C. B., Normann, C., Nutt, D., Pallanti, S., Pani, L., Penninx, B. W. J. H., Schatzberg, A. F., Shelton, R. C., Yatham, L. N., Young, A. H., Zahn, R., Aislaitner, G., Butlen-Ducuing, F., Fletcher, C., Haberkamp, M., Laughren, T., Mäntylä, F-L., Schruers, K., Thomson, A., Arteaga-Henríquez, G., Benedetti, F., Cash-Gibson, L., Chae, W. R., de Smedt, H., Gold, S. M., Hoogendijk, W. J. G., Mondragón, V. J., Maron, E., Martynowicz, J., Melloni, E., Otte, C., Perez-Fuentes, G., Poletti, S., Schmidt, M. E., van de Ketterij, E., Woo, K., Flossbach, Y., Ramos-Quiroga, J. A., Savitz, A. J. & Pariante, C. M., 2022, In: Molecular psychiatry. 27, p. 1286-1299 14 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  69 Citations (Scopus)

• Demystifying non-coding GWAS variants: an overview of computational tools and methods

  Schipper, M. & Posthuma, D., 15 Oct 2022, In: Human Molecular Genetics. 31, R1, p. R73-R83

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Heterogeneity of white matter astrocytes in the human brain

  Bugiani, M., Plug, B. C., Man, J. H. K., Breur, M. & van der Knaap, M. S., Feb 2022, In: Acta Neuropathologica. 143, 2, p. 159-177 19 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  17 Citations (Scopus)

• How COVID-19 shaped mental health: from infection to pandemic effects

  Penninx, B. W. J. H., Benros, M. E., Klein, R. S. & Vinkers, C. H., Oct 2022, In: Nature medicine. 28, 10, p. 2027-2037 11 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  112 Citations (Scopus)

• Inflammation and depression in young people: a systematic review and proposed inflammatory pathways

  Toenders, Y. J., Laskaris, L., Davey, C. G., Berk, M., Milaneschi, Y., Lamers, F., Penninx, B. W. J. H. & Schmaal, L., Jan 2022, In: Molecular psychiatry. 27, 1, p. 315-327 13 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  26 Citations (Scopus)

• Personalized medicine for rare neurogenetic disorders: can we make it happen?

  van Eeghen, A. M., Bruining, H., Wolf, N. I., Bergen, A. A., Houtkooper, R. H., van Haelst, M. M. & van Karnebeek, C. D., 1 Feb 2022, In: Cold Spring Harbor molecular case studies. 8, 2, a006200.

  Research output: Contribution to journal › Review article › Academic › peer-review
  5 Citations (Scopus)

• The neurovascular unit in leukodystrophies: towards solving the puzzle

  Zarekiani, P., Nogueira Pinto, CH., Hol, E. M., Bugiani, M. & de Vries, HE., Dec 2022, In: Fluids and barriers of the CNS. 19, 1, p. 18 18.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  5 Citations (Scopus)

• Understanding the assumptions underlying Mendelian randomization

  de Leeuw, C., Savage, J., Bucur, I. G., Heskes, T. & Posthuma, D., Jun 2022, In: European journal of human genetics. 30, 6, p. 653-660 8 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  35 Citations (Scopus)
• 2023

  From fossils to mind

  de Sousa, A. A., Beaudet, A., Calvey, T., Bardo, A., Benoit, J., Charvet, C. J., Dehay, C., Gómez-Robles, A., Gunz, P., Heuer, K., van den Heuvel, M. P., Hurst, S., Lauters, P., Reed, D., Salagnon, M., Sherwood, C. C., Ströckens, F., Tawane, M., Todorov, O. S., Toro, R., & 1 othersWei, Y., 1 Dec 2023, In: Communications Biology. 6, 1, p. 1-21 21 p., 636.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Major depressive disorder

  Marx, W., Penninx, B. W. J. H., Solmi, M., Furukawa, T. A., Firth, J., Carvalho, A. F. & Berk, M., 1 Dec 2023, In: NATURE REVIEWS DISEASE PRIMERS. 9, 1, 44.

  Research output: Contribution to journal › Review article › Academic › peer-review
  16 Citations (Scopus)

• Statistical power in network neuroscience

  Helwegen, K., Libedinsky, I. & van den Heuvel, M. P., 1 Mar 2023, In: Trends in cognitive sciences. 27, 3, p. 282-301 20 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  11 Citations (Scopus)

• The Gut Microbiome in Early Life Stress: A Systematic Review

  Agusti, A., Lamers, F., Tamayo, M., Benito-Amat, C., Molina-Mendoza, G. V., Penninx, B. W. J. H. & Sanz, Y., 1 Jun 2023, In: NUTRIENTS. 15, 11, 2566.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• The usability of daytime and night-time heart rate dynamics as digital biomarkers of depression severity

  PAB Members & RADAR-CNS Consortium, 15 Jun 2023, In: Psychological Medicine. 53, 8, p. 3249-3260 12 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Understanding the Ultra-Rare Disease Autosomal Dominant Leukodystrophy: an Updated Review on Morpho-Functional Alterations Found in Experimental Models

  Neri, I., Ramazzotti, G., Mongiorgi, S., Rusciano, I., Bugiani, M., Conti, L., Cousin, M., Giorgio, E., Padiath, Q. S., Vaula, G., Cortelli, P., Manzoli, L. & Ratti, S., Nov 2023, In: Molecular neurobiology. 60, 11, p. 6362-6372 11 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  2 Citations (Scopus)
• 2024

  Is Osteogenesis Imperfecta Associated with Cardiovascular Abnormalities? A Systematic Review of the Literature

  Verdonk, S. J. E., Storoni, S., Micha, D., van den Aardweg, J. G., Versacci, P., Celli, L., de Vries, R., Zhytnik, L., Kamp, O., Bugiani, M. & Eekhoff, E. M. W., Mar 2024, In: Calcified tissue international. 114, 3, p. 210-221 12 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access

• Long-term glucocorticoids in relation to the metabolic syndrome and cardiovascular disease: A systematic review and meta-analysis

  Kuckuck, S., Lengton, R., Boon, M. R., Boersma, E., Penninx, B. W. J. H., Kavousi, M. & van Rossum, E. F. C., Jan 2024, In: Journal of Internal Medicine. 295, 1, p. 2-19 18 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access

• The pathology of X-linked adrenoleukodystrophy: tissue specific changes as a clue to pathophysiology

  Yska, H. A. F., Engelen, M. & Bugiani, M., 1 Dec 2024, In: Orphanet Journal of Rare Diseases. 19, 1, 138.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access