Projects per year
Personal profile
Research interests
My research aim is to contribute to improved, personalized treatment for depression, through research on (treatment of) immuno-metabolic depression & application of ambulatory measurements therein.
The concept of immuno-metabolic depression started with my 2010 publication on depression subtypes in Journal of Clinical Psychiatry, and has led to a solid line of research on this form of depression, that is characterized by atypical, energy-related symptoms and inflammation and metabolic dysregulation. In 2010, I was awarded an NWO Rubicon fellowship to conduct research on depression subtypes at the National Institute of Mental Health, USA with dr. K. Merikangas. In 2013 I returned to Amsterdam supported by a EU-FP7 Marie Curie Career Integration Grant where I continued my work on depression subtypes and immuno-metabolic depression (IMD). I am currently PI of the PERCIM project, where we are evaluating personalized treatment options for IMD as well as the INFLAMED study, an RCT on add-on Celecoxib for immune-metabolic depression.
At the NIMH, I also learned about ambulatory assessments, such as ecological momentary assessment (EMA) and actigraphy. Upon my return to Amsterdam, I contributed to the implementation of EMA and actigraphy in the Netherlands Study on Depression and Anxiety. I have been coördinating the Dutch arm of the RADAR-CNS depression study, that employed ambulatory assessments, including EMA, passive smartphone apps and actigraphy to monitor depression in an effort to identify signals that could indicate a relapse. Data of this project is currently being analysed. In addition, I am part of the NWO Gravitation project Stress in Action. This 10-year program will capitalize on the fast advances in technology and big data analytics to move stress research from the lab to daily life. I am currently also on the Executive Board of Stress in Action.
Besides being passionate about research, I have a keen interest in teaching and training. My teaching aim is to bring training of young academics to the highest level, by creating an optimal training atmosphere and setting to conduct research according to the highest standards.
Twitter account: @LamersFemke
specialisation
Psychiatric epidemiology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Postdoctoral research fellow, NIH
1 May 2010 → 28 Apr 2013
PhD student, Maastricht University
15 Jun 2003 → 1 Apr 2008
Collaborations and top research areas from the last five years
Projects
- 3 Active
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Stress in Action
Penninx, B., Lamers, F., Peyrot, W., Vinkers, C., van Zwieten, N., Aalbers, G., Ross Adelman, M., de Geus, E. J. C., Bartels, M., Pruin, E., Broeder, C., Pasteuning, J., Noordzij, M., Hillegers, M., de Jonge, P. & Bultmann, U.
1/01/2023 → 31/12/2032
Project: Research
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inflaMED: Precision psychiatry: Anti-inflammatory medication in Immuno-metabolic depression
Lamers, F., Milaneschi, Y., Penninx, B., Vinkers, C. & Zwiep, J.
1/09/2021 → 31/08/2025
Project: Research
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PERCIM: Personalized Care for Depression: Bringing Immuno-Metabolic Depression from Bench to Bedside
Lamers, F., Jansen, R., Vreijling, S., Penninx, B., Beekman, A., Bot, M., Milaneschi, Y., Bremmer, M. & Rhebergen, D.
1/10/2019 → 30/04/2024
Project: Research
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The Tale of Depression and Inflammation Unraveled: On Depression Measurement Levels and Next Steps
Lamers, F., 1 Feb 2023, In: Biological Psychiatry. 93, 3, p. 211-212 2 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
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The role of depressive symptoms and symptom dimensions in actigraphy-assessed sleep, circadian rhythm, and physical activity
Difrancesco, S., Penninx, B. W. J. H., Riese, H., Giltay, E. J. & Lamers, F., 2022, In: Psychological Medicine. 52, p. 2760-2766 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access7 Citations (Scopus) -
Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression
Milaneschi, Y., Lamers, F., Berk, M. & Penninx, B. W. J. H., 1 Sept 2020, In: Biological Psychiatry. 88, 5, p. 369-380 12 p.Research output: Contribution to journal › Review article › Academic › peer-review
170 Citations (Scopus) -
Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression
Lamers, F., Vogelzangs, N., Merikangas, K. R., de Jonge, P., Beekman, A. T. F. & Penninx, B. W. J. H., 2013, In: Molecular psychiatry. 18, 6, p. 692-699Research output: Contribution to journal › Article › Academic › peer-review
522 Citations (Scopus) -
Depression profilers and immuno-metabolic dysregulation: Longitudinal results from the NESDA study
Lamers, F., Milaneschi, Y., Vinkers, C. H., Schoevers, R. A., Giltay, E. J. & Penninx, B. W. J. H., Aug 2020, In: Brain, behavior, and immunity. 88, p. 174-183 10 p.Research output: Contribution to journal › Article › Academic › peer-review
69 Citations (Scopus)
Datasets
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Supplementary Material for: The Accuracy of the Patient Health Questionnaire-9 Algorithm for Screening to Detect Major Depression: An Individual Participant Data Meta-Analysis
He, C. (Creator), Levis, B. (Creator), Riehm, K. E. (Creator), Saadat, N. (Creator), Levis, A. W. (Creator), Azar, M. (Creator), Rice, D. B. (Creator), Krishnan, A. (Creator), Wu, Y. (Creator), Sun, Y. (Creator), Imran, M. (Creator), Boruff, J. (Creator), Cuijpers, P. (Creator), Gilbody, S. (Creator), Ioannidis, J. P. A. (Contributor), Kloda, L. A. (Creator), McMillan, D. (Creator), Patten, S. B. (Creator), Shrier, I. (Creator), Ziegelstein, R. C. (Creator), Akena, D. H. (Creator), Arroll, B. (Creator), Ayalon, L. (Creator), Baradaran, H. R. (Creator), Baron, M. (Creator), Beraldi, A. (Creator), Bombardier, C. H. (Creator), Butterworth, P. (Creator), Carter, G. (Creator), Chagas, M. H. N. (Contributor), Chan, J. C. N. (Contributor), Cholera, R. (Creator), Clover, K. (Creator), Conwell, Y. (Creator), Fann, J. R. (Creator), Fischer, F. H. (Creator), Fung, D. (Creator), Gelaye, B. (Creator), Goodyear-Smith, F. (Creator), Greeno, C. G. (Creator), Hall, B. J. (Creator), Harrison, P. A. (Creator), Härter, M. (Creator), Hegerl, U. (Creator), Hides, L. (Creator), Hobfoll, S. E. (Creator), Hudson, M. (Creator), Hyphantis, T. N. (Creator), Inagaki, M. (Creator), Ismail, K. (Creator), Jetté, N. (Creator), Khamseh, M. E. (Creator), Kiely, K. M. (Creator), Kwan, Y. (Creator), Lamers, F. (Creator), Liu, S. (Creator), Lotrakul, M. (Creator), Loureiro, S. R. (Creator), Löwe, B. (Creator), Marsh, L. (Creator), McGuire, A. (Creator), Mohd-Sidik, S. (Creator), Munhoz, T. N. (Creator), Muramatsu, K. (Creator), Osório, F. L. (Creator), Patel, V. (Creator), Pence, B. W. (Creator), Persoons, P. (Creator), Picardi, A. (Creator), Reuter, K. (Creator), Rooney, A. G. (Creator), Shaaban, J. (Creator), Sidebottom, A. (Creator), Simning, A. (Creator), Stafford, L. (Creator), Sung, S. (Creator), Tan, P. L. L. (Contributor), Turner, A. (Creator), White, J. (Creator), Whooley, M. A. (Creator), Winkley, K. (Creator), Yamada, M. (Creator), Thombs, B. D. (Creator) & Benedetti, A. (Creator), Karger Publishers, 2019
DOI: 10.6084/m9.figshare.9949181, https://karger.figshare.com/articles/Supplementary_Material_for_The_Accuracy_of_the_Patient_Health_Questionnaire-9_Algorithm_for_Screening_to_Detect_Major_Depression_An_Individual_Participant_Data_Meta-Analysis/9949181
Dataset
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Supplementary Material for: The Accuracy of the Patient Health Questionnaire-9 Algorithm for Screening to Detect Major Depression: An Individual Participant Data Meta-Analysis
He, C. (Contributor), Levis, B. (Contributor), Riehm, K. E. (Contributor), Saadat, N. (Contributor), Levis, A. W. (Contributor), Azar, M. (Contributor), Rice, D. B. (Contributor), Krishnan, A. (Contributor), Wu, Y. (Contributor), Sun, Y. (Contributor), Imran, M. (Contributor), Boruff, J. (Contributor), Cuijpers, P. (Contributor), Gilbody, S. (Contributor), Ioannidis, J. P. A. (Contributor), Kloda, L. A. (Contributor), McMillan, D. (Contributor), Patten, S. B. (Contributor), Shrier, I. (Contributor), Ziegelstein, R. C. (Contributor), Akena, D. H. (Contributor), Arroll, B. (Contributor), Ayalon, L. (Contributor), Baradaran, H. R. (Contributor), Baron, M. (Contributor), Beraldi, A. (Contributor), Bombardier, C. H. (Contributor), Butterworth, P. (Contributor), Carter, G. (Contributor), Chagas, M. H. N. (Contributor), Chan, J. C. N. (Contributor), Cholera, R. (Contributor), Clover, K. (Contributor), Conwell, Y. (Contributor), DeMan-VanGinkel, J. M. (Contributor), Fann, J. R. (Contributor), Fischer, F. H. (Contributor), Fung, D. (Contributor), Gelaye, B. (Contributor), Goodyear-Smith, F. (Contributor), Greeno, C. G. (Contributor), Hall, B. J. (Contributor), Harrison, P. A. (Contributor), Härter, M. (Contributor), Hegerl, U. (Contributor), Hides, L. (Contributor), Hobfoll, S. E. (Contributor), Hudson, M. (Contributor), Hyphantis, T. N. (Contributor), Inagaki, M. (Contributor), Ismail, K. (Contributor), Jetté, N. (Contributor), Khamseh, M. E. (Contributor), Kiely, K. M. (Contributor), Kwan, Y. (Contributor), Lamers, F. (Contributor), Liu, S. (Contributor), Lotrakul, M. (Contributor), Loureiro, S. R. (Contributor), Löwe, B. (Contributor), Marsh, L. (Contributor), McGuire, A. (Contributor), Mohd-Sidik, S. (Contributor), Munhoz, T. N. (Contributor), Muramatsu, K. (Contributor), Osório, F. L. (Contributor), Patel, V. (Contributor), Pence, B. W. (Contributor), Persoons, P. (Contributor), Picardi, A. (Contributor), Reuter, K. (Contributor), Rooney, A. G. (Contributor), DaSilvadosSantos, I. S. (Contributor), Shaaban, J. (Contributor), Sidebottom, A. (Contributor), Simning, A. (Contributor), Stafford, L. (Contributor), Sung, S. (Contributor), Tan, P. L. L. (Contributor), Turner, A. (Contributor), VanWeert, H. C. P. M. (Contributor), White, J. (Contributor), Whooley, M. A. (Contributor), Winkley, K. (Contributor), Yamada, M. (Contributor), Thombs, B. D. (Contributor) & Benedetti, A. (Contributor), Unknown Publisher, 1 Jan 2020
DOI: 10.6084/m9.figshare.9949181.v1, https://karger.figshare.com/articles/Supplementary_Material_for_The_Accuracy_of_the_Patient_Health_Questionnaire-9_Algorithm_for_Screening_to_Detect_Major_Depression_An_Individual_Participant_Data_Meta-Analysis/9949181/1
Dataset
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Supplementary Material for: Probability of Major Depression Classification Based on the SCID, CIDI, and MINI Diagnostic Interviews: A Synthesis of Three Individual Participant Data Meta-Analyses
Spangenberg, L. (Contributor), McMillan, D. (Contributor), Ponsford, J. L. (Contributor), Robertson-Blackmore, E. (Contributor), Shaaban, J. (Contributor), Patten, S. B. (Contributor), Martin-Santos, R. (Contributor), Tendais, I. (Contributor), Jette, N. (Contributor), Luwa E-Andjafono, D. O. (Contributor), Amtmann, D. (Contributor), Wang, W. (Contributor), Flint, A. J. (Contributor), Chan, J. C. N. (Contributor), Su, K. (Contributor), Conwell, Y. (Contributor), Cholera, R. (Contributor), Sundstr?m-Poromaa, I. (Contributor), Tandon, S. D. (Contributor), Kim, S. (Contributor), Thiagayson, P. (Contributor), Trevillion, K. (Contributor), Os?rio, F. L. (Contributor), Reme, S. E. (Contributor), Keller, M. (Contributor), Wu, Y. (Contributor), Downing, M. G. (Contributor), Navarrete, L. (Contributor), Hall, B. J. (Contributor), Van Der Feltz-Cornelis, C. M. (Contributor), Cuijpers, P. (Contributor), Chen, C. (Contributor), Saadat, N. (Contributor), Field, S. (Contributor), Green, E. P. (Contributor), Tonelli, M. (Contributor), Leonardou, A. A. (Contributor), Azar, M. (Contributor), Vega-Dienstmaier, J. M. (Contributor), Goodyear-Smith, F. (Contributor), Baradaran, H. R. (Contributor), Pugh, S. L. (Contributor), Boruff, J. (Contributor), Mehner, A. (Contributor), Yamada, M. (Contributor), Shinn, E. H. (Contributor), Lara, M. A. (Contributor), Zhang, Y. (Contributor), Lowe, B. (Contributor), Mitchell, N. D. (Contributor), Reuter, K. (Contributor), Massardo, L. (Contributor), Conway, A. (Contributor), Al-Adawi, S. (Contributor), Wagner, L. I. (Contributor), Stafford, L. (Contributor), Garman, E. C. (Contributor), Dabscheck, E. (Contributor), Ziegelstein, R. C. (Contributor), Diez-Quevedo, C. (Contributor), S?nchez-Gonz?lez, R. (Contributor), Howard, L. M. (Contributor), Bhana, A. (Contributor), Alvarado, R. (Contributor), Fujimori, M. (Contributor), Fann, J. R. (Contributor), Feinstein, A. (Contributor), Hudson, M. (Contributor), Simard, S. (Contributor), Van Weert, H. C. (Contributor), Muramatsu, K. (Contributor), Bindt, C. (Contributor), Conroy, R. M. (Contributor), Wong, D. K. (Contributor), Giardinelli, L. (Contributor), Gelaye, B. (Contributor), V?hringer, P. A. (Contributor), Sung, S. C. (Contributor), Figueiredo, B. (Contributor), Pintor, L. (Contributor), Kloda, L. A. (Contributor), Garcia, P. N. (Contributor), Gandy, M. (Contributor), De Figueiredo, F. P. (Contributor), Riehm, K. E. (Contributor), Kozinszky, Z. (Contributor), Van Heyningen, T. (Contributor), Helle, N. (Contributor), Rowe, H. J. (Contributor), Lotrakul, M. (Contributor), Bombardier, C. H. (Contributor), Turner, A. (Contributor), Skalkidou, A. (Contributor), Arroll, B. (Contributor), Singer, S. (Contributor), Tran, T. D. (Contributor), Sun, Y. (Contributor), Thombs, B. D. (Contributor), Chagas, M. H. (Contributor), Matsuoka, Y. (Contributor), Bhandari, P. M. (Contributor), Teixeira, A. L. (Contributor), Misery, L. (Contributor), Fisher, J. R. W. (Contributor), Yonkers, K. A. (Contributor), Barnes, J. (Contributor), Tan, P. L. L. (Contributor), Alamri, S. H. (Contributor), Negeri, Z. (Contributor), Akena, D. H. (Contributor), Stewart, R. C. (Contributor), Hegerl, U. (Contributor), Hobfoll, S. E. (Contributor), Lund, C. (Contributor), Ioannidis, J. P. A. (Contributor), Schwarzbold, M. L. (Contributor), Beck, C. T. (Contributor), Gallagher, P. (Contributor), Meuti, V. (Contributor), Loiselle, C. G. (Contributor), Michopoulos, I. (Contributor), Hides, L. (Contributor), Munhoz, T. N. (Contributor), Grassi, L. (Contributor), Ferentinos, P. P. (Contributor), Wang, L. (Contributor), ?zt?rk, A. (Contributor), Kohrt, B. A. (Contributor), Yan, X. W. (Contributor), Bavle, A. D. (Contributor), Hantsoo, L. (Contributor), Turner, K. (Contributor), Clover, K. (Contributor), Rado?, S. N. (Contributor), Vigod, S. N. (Contributor), Douven, E. (Contributor), Boyce, P. M. (Contributor), Chaudron, L. H. (Contributor), Levis, A. W. (Contributor), Torres-Gim?nez, A. (Contributor), O'Donnell, M. L. (Contributor), Tiringer, I. (Contributor), Rooney, A. G. (Contributor), Sidebottom, A. (Contributor), Picardi, A. (Contributor), Shrier, I. (Contributor), Zeng, Q. Z. (Contributor), Kohler, S. (Contributor), Hyphantis, T. (Contributor), Harter, M. (Contributor), Lamers, F. (Contributor), Bunevicius, R. (Contributor), T?reki, A. (Contributor), Sanchez, T. A. (Contributor), Ayalon, L. (Contributor), Luitel, N. P. (Contributor), Bunevicius, A. (Contributor), Alvarado-Esquivel, C. (Contributor), Quinn, T. J. (Contributor), Fernandes, M. (Contributor), Marx, B. P. (Contributor), Greeno, C. G. (Contributor), Kiely, K. M. (Contributor), De Man-Van Ginkel, J. M. (Contributor), Henry, M. (Contributor), Bakare, M. O. (Contributor), Gilbody, S. (Contributor), Beraldi, A. (Contributor), Lelli, L. (Contributor), Rice, D. B. (Contributor), Cukor, D. (Contributor), Loureiro, S. R. (Contributor), Nishi, D. (Contributor), Castro E Couto, T. (Contributor), Garcia-Esteve, L. (Contributor), Gholizadeh, L. (Contributor), Levin-Aspenson, H. F. (Contributor), Maes, M. (Contributor), Kjargaard, M. (Contributor), Correa, H. (Contributor), Eapen, V. (Contributor), Imran, M. (Contributor), Sidik, S. M. (Contributor), Buji, R. I. (Contributor), Tung, K. (Contributor), Navines, R. (Contributor), Siu, B. W. M. (Contributor), Fischer, F. H. (Contributor), Butterworth, P. (Contributor), Sharpe, L. (Contributor), Cankorur, V. S. (Contributor), Fung, D. S. S. (Contributor), Kwan, Y. (Contributor), Chan, L. F. (Contributor), Khalifa, D. S. (Contributor), Rochat, T. J. (Contributor), Levis, B. (Contributor), Kohlhoff, J. (Contributor), Rancans, E. (Contributor), Benedetti, A. (Contributor), Marrie, R. A. (Contributor), Khamseh, M. E. (Contributor), Stein, A. (Contributor), Pence, B. W. (Contributor), Schram, M. T. (Contributor), Wang, J. L. (Contributor), Neupane, D. (Contributor), Carter, G. (Contributor), He, C. (Contributor), Santos, I. S. (Contributor), Honikman, S. (Contributor), Rathod, S. D. (Contributor), Suzuki, K. (Contributor), Jenewein, J. (Contributor), Stone, J. (Contributor), Walterfang, M. (Contributor), Wynter, K. (Contributor), Daray, F. M. (Contributor), Chiovitti, M. J. (Contributor), Peceliuniene, J. (Contributor), Marsh, L. (Contributor), Nakku, J. E. M. (Contributor), Bernstein, C. N. (Contributor), Haroz, E. E. (Contributor), Persoons, P. (Contributor), Sultan, S. (Contributor), White, J. (Contributor), Simning, A. (Contributor), Tadinac, M. (Contributor), Krishnan, A. (Contributor), Comeau, L. (Contributor), Inagaki, M. (Contributor), Jeon, H. J. (Contributor), B?el-Drabe, N. (Contributor), Kusminskas, L. (Contributor), Gibson, L. J. (Contributor), Taylor-Rowan, M. (Contributor), Ismail, Z. (Contributor) & Butnoriene, J. (Contributor), figshare Academic Research System, 1 Jan 2020
DOI: 10.6084/m9.figshare.12826841.v1, https://doi.org/10.6084%2Fm9.figshare.12826841.v1
Dataset
Activities
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Immunometabolic dysregulations in major depressive disorder: implications and examples for personalized treatment
Femke Lamers (Speaker)
16 Dec 2023Activity: Lecture / Presentation › Oral presentation › Academic
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Amsterdam UMC Doctoral School Board (External organisation)
Femke Lamers (Member)
Jul 2023 → …Activity: Membership › Membership of board › Professional
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De verschillende gezichten van depressie: Het voorbeeld van immuno-metabole depressie
Femke Lamers (Speaker)
1 Apr 2021Activity: Lecture / Presentation › Invited talk › Academic
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Dutch Neuroscience meeting: neuro-immunology in neurological diseases
Femke Lamers (Participant)
10 Jun 2021Activity: Participating in or organising an event › Organising a conference, workshop, ... › Academic
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APH - Mental Health (Organisational unit)
Femke Lamers (Chair)
1 Jun 2021 → …Activity: Membership › Membership of committee › Academic