Research output per year
Research output per year
Personal profile
Research interests
My research, at Sanquin, focusses on Immune modulation and Antigen-specific Immunomonitoring, with a specific focus on antigen-specific CD4 T cell and B cell responses.
My group specializes in monitoring the effects of immunomodulatory therapies on the immune system. With a specific focus on the analysis of antigen-specific immune responses, mainly CD4+ T cells and B cells, as the function of these cells is crucial for the efficacy of immunotherapeutic approaches such as vaccinations or tolerizing therapies and pathologies, such as their role in RBC alloimmunization.
I am workpackage leader of the centralized immunomonitoring package of EU H2020 RESTORE (Neuronal self-renewal by antigen-specific tolerization in multiple sclerosis reinstalling the balance between inflammation and regeneration), in which 2 clinical trials are conducted in which tolerogenic dendritic cells are applied to MS patients. Besides we participate currently in the immunomonitoring workpackages of 2 national consortia, Target2B and DC4balance.
specialisation
Immunomonitoring, Antigen-specific CD4 T cells, B cells, Immune modulation, Autoimmunity
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Inhibition of Dendritic Cell Activation and Modulation of T Cell Polarization by the Platelet Secretome
Saris, A., Steuten, J., Schrijver, D. P., van Schijndel, G., Zwaginga, J. J., van Ham, S. M. & ten Brinke, A., 25 Feb 2021, In: Frontiers in immunology. 12, 12 p., 631285.Research output: Contribution to journal › Article › Academic › peer-review
Open Access10 Citations (Scopus) -
Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients
Oja, A. E., Saris, A., Ghandour, C. A., Kragten, N. A. M., Hogema, B. M., Nossent, E. J., Heunks, L. M. A., Cuvalay, S., Slot, E., Linty, F., Swaneveld, F. H., Vrielink, H., Vidarsson, G., Rispens, T., van der Schoot, E., van Lier, R. A. W., ten Brinke, A. & Hombrink, P., Dec 2020, In: European journal of immunology. 50, 12, p. 1998-2012 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access88 Citations (Scopus) -
Guidelines for analysis of low-frequency antigen-specific T cell results: Dye-based proliferation assay vs 3H-thymidine incorporation
di Blasi, D., Claessen, I., Turksma, A. W., van Beek, J. & ten Brinke, A., Dec 2020, In: Journal of immunological methods. 487, 112907.Research output: Contribution to journal › Article › Academic › peer-review
Open Access12 Citations (Scopus) -
Ways forward for tolerance-inducing cellular therapies- An afactt perspective
ten Brinke, A., Martinez-Llordella, M., Cools, N., Hilkens, C. M. U., van Ham, S. M., Sawitzki, B., Geissler, E. K., Lombardi, G., Trzonkowski, P. & Martinez-Caceres, E., 22 Feb 2019, In: Frontiers in immunology. 10, FEB, 20 p., 181.Research output: Contribution to journal › Article › Academic › peer-review
Open Access35 Citations (Scopus) -
Storage-induced platelet apoptosis is a potential risk factor for alloimmunization upon platelet transfusion
Saris, A., Peyron, I., van der Meer, P. F., Stuge, T. B., Zwaginga, J. J., van Ham, S. M. & ten Brinke, A., 5 Jun 2018, In: Frontiers in immunology. 9, JUN, 1251.Research output: Contribution to journal › Article › Academic › peer-review
Open Access18 Citations (Scopus)