Projects per year
Personal profile
specialisation
Cellular glycosylation is a highly dynamic process that alters upon activation, inflammation, and oncogenic transformation. Although it has been known for decades that cell surface glycans are highly diverse, it is still unclear how glycan heterogeneity is established and how this impacts tumor cell biology and immune cell recognition.
During my cum laude PhD and postdoctoral years I studied the impact of glycosylation and glycan-binding receptors on dendritic cell biology and specialized in the field of glyco-immunology. I obtained a prestigious NWO-VENI grant in 2010 that allowed me to dissect the signaling properties of glycan-binding receptors. With grants from the Dutch Cancer Society, Cancer Center Amsterdam and European Marie Curie ITN network and NWO-ASPASIA, I have established her own independent research group that aims to unravel how tumor glycans affect tumor progression, metastasis and anti-tumor immunity.
Research interests
Immunology, glycosylation, dendritic cells, glycan-binding receptors, anti-tumor immunity
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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FUCOSYLATED GLYCAN EPITOPES AS NOVEL IMMUNE CHECKPOINT MOLECULES IN COLORECTAL CANCER
van Vliet, S., van Kooyk, Y., van Egmond, M. & Hatinguais, R.
1/06/2023 → 31/05/2026
Project: Research
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Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions
Boelaars, K., Rodriguez, E., Huinen, Z. R., Liu, C., Wang, D., Springer, B. O., Olesek, K., Goossens-Kruijssen, L., van Ee, T., Lindijer, D., Tak, W., de Haas, A., Wehry, L., Nugteren-Boogaard, J. P., Mikula, A., de Winde, C. M., Mebius, R. E., Tuveson, D. A., Giovannetti, E., Bijlsma, M. F., & 3 others, 9 Apr 2024, In: Communications Biology. 7, 1, p. 430Research output: Contribution to journal › Article › Academic › peer-review
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Sialic acid–modified der p 2 allergen exerts immunomodulatory effects on human PBMCs
Keumatio Doungtsop, B-C., Nardini, E., Kalay, H., Versteeg, S. A., Lübbers, J., van Barneveld, G., Li, E. R. J., van Vliet, S. J., van Ree, R., de Jong, E. C. & van Kooyk, Y., 1 Feb 2024, In: Journal of Allergy and Clinical Immunology: Global. 3, 1, p. 100193 100193.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
The transcriptional landscape of glycosylation-related genes in cancer
Rodriguez, E., Lindijer, D. V., van Vliet, S. J., Garcia Vallejo, J. J. & van Kooyk, Y., 15 Mar 2024, In: iScience. 27, 3, 109037.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Current state-of-the-art on ganglioside-mediated immune modulation in the tumor microenvironment
van der Haar Àvila, I., Windhouwer, B. & van Vliet, S. J., Sept 2023, In: Cancer and Metastasis Reviews. 42, 3, p. 941-958 18 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access6 Citations (Scopus) -
Dysregulation of developmental and cell type-specific expression of glycoconjugates on hematopoietic cells: a new characteristic of myelodysplastic neoplasms (MDS)
van Spronsen, M. F., Horrevorts, S., Cali, C., Westers, T. M., van Gassen, S., Saeys, Y., van Vliet, S. J., van Kooyk, Y. & van de Loosdrecht, A. A., Mar 2023, In: Leukemia. 37, 3, p. 702-707 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus)
Activities
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New horizons in immunology
Sandra van Vliet (Organiser)
23 Mar 2023 → 24 Mar 2023Activity: Participating in or organising an event › Organising a conference, workshop, ... › Academic
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TUMOR-ASSOCIATED GLYCAN STRUCTURES: FRIEND OR FOE IN IMMUNITY TO CANCER?
Sandra van Vliet (Speaker)
20 Apr 2023 → 21 Apr 2023Activity: Lecture / Presentation › Invited talk › Academic
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Member of the opposition: M. Quiles del Rey
Sandra van Vliet (Examiner)
13 Jan 2023Activity: PhD thesis Examination › Examination › Educational
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TUMOR-ASSOCIATED GLYCAN STRUCTURES: FRIEND OR FOE IN IMMUNITY TO CANCER?
Sandra van Vliet (Speaker)
14 Jun 2023 → 16 Jun 2023Activity: Lecture / Presentation › Invited talk › Academic
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Glycoscience NL 2023
Sandra van Vliet (Participant)
2 Jun 2023Activity: Participating in or organising an event › Participating in a conference, workshop, ... › Academic
Press/Media
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Journal club for "Antibuddies - Science communication & immunology"
18/09/2021
1 Media contribution
Press/Media: Public Engagement Activities