Research output per year
Research output per year
Personal profile
Research interests
My research interests revolve around immunotherapy of NSCLC patients; how can we improve treatment outcome for this patient group. I try to understand why immunotherapy (combinatorial strategies) are effective in some NSCLC patients and not at all in others, and use this knowledge to stratify patients or improve treatment design. In order to achieve this, I make use of multi-color flowcytometry, ELISA, cell-culture, cytokine assays and histology to evaluate blood, tumor-draining lymph nodes and tumor from NSCLC patients.
specialisation
Immunotherapy ,
specialisation
Immunotherapy, Lymph Node, NSCLC, Biomarkers, Intratumoral
Keywords
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
- immunotherapy
- lymph node
- NSCLC
- Biomarkers
- intratumoral
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Multi-modal cell-free DNA genomic and fragmentomic patterns enhance cancer survival and recurrence analysis
Moldovan, N., van der Pol, Y., van den Ende, T., Boers, D., Verkuijlen, S., Creemers, A., Ramaker, J., Vu, T., Bootsma, S., Lenos, K. J., Vermeulen, L., Fransen, M. F., Pegtel, M., Bahce, I., van Laarhoven, H. & Mouliere, F., 16 Jan 2024, In: Cell Reports Medicine. 5, 1, 101349.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
A Bispecific γδ T-cell Engager Targeting EGFR Activates a Potent Vγ9Vδ2 T cell-Mediated Immune Response against EGFR-Expressing Tumors
King, L. A., Toffoli, E. C., Veth, M., Iglesias-Guimarais, V., Slot, M. C., Amsen, D., van de Ven, R., Derks, S., Fransen, M. F., Tuynman, J. B., Riedl, T., Roovers, R. C., Adang, A. E. P., Ruben, J. M., Parren, P. W. H. I., de Gruijl, T. D. & van der Vliet, H. J., 1 Sept 2023, In: Cancer immunology research. 11, 9, p. 1237-1252 16 p.Research output: Contribution to journal › Article › Academic › peer-review
4 Citations (Scopus) -
Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors
Knopf, P., Stowbur, D., Hoffmann, S. H. L., Hermann, N., Maurer, A., Bucher, V., Poxleitner, M., Tako, B., Sonanini, D., Krishnamachary, B., Sinharay, S., Fehrenbacher, B., Gonzalez-Menendez, I., Reckmann, F., Bomze, D., Flatz, L., Kramer, D., Schaller, M., Forchhammer, S., Bhujwalla, Z. M., & 9 others, 1 Dec 2023, In: Molecular Cancer. 22, 1, 207.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Preclinical Identification Of Tumor-Draining Lymph Nodes Using a Multimodal Non-invasive In vivo Imaging Approach
Knopf, P., Stowbur, D., Hoffmann, S. H. L., Fransen, M. F., Schwenck, J., Pichler, B. J. & Kneilling, M., Jun 2023, In: Molecular Imaging and Biology. 25, 3, p. 606-618 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Predictive Value of Combined Positive Score and Tumor Proportion Score for Immunotherapy Response in Advanced NSCLC
Ulas, E. B., Hashemi, S. M. S., Houda, I., Kaynak, A., Veltman, J. D., Fransen, M. F., Radonic, T. & Bahce, I., 1 Sept 2023, In: JTO Clinical and Research Reports. 4, 9, 100532.Research output: Contribution to journal › Article › Academic › peer-review
Open Access6 Citations (Scopus)
Activities
- 1 Organising a conference, workshop, ...
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Dutch Tumor Immunology Meeting
Marieke Fransen (Organiser)
1 Jan 2018 → 1 Jan 4000Activity: Participating in or organising an event › Organising a conference, workshop, ... › Academic