A. Marijne Heeren

Research output

Research output per year 2015 2015 2016 2017 2018 2019 2021

• 18 Article
• 2 Meeting Abstract
• 1 Review article
• 1 Phd-Thesis - Research and graduation internal

Research output per year

Research output per year

Search results

• 2021

  Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth

  Heeren, A. M., Rotman, J., Samuels, S., Zijlmans, H. J. M. A. A., Fons, G., Van De Vijver, K. K., Bleeker, M. C. G., Kenter, G. G., Jordanova, E. J. & De Gruijl, T. D., 25 Oct 2021, In: Journal for Immunotherapy of Cancer. 9, 10, e003623.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  12 Citations (Scopus)
• 2020

  Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8+ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma

  Rotman, J., Heeren, A. M., Gassama, A. A., Lougheed, S. M., Pocorni, N., Stam, A. G. M., Bleeker, M. C. G., Zijlmans, H. J. M. A. A., Mom, C. H., Kenter, G. G., Jordanova, E. S. & de Gruijl, T. D., 15 Jul 2020, In: Clinical Cancer Research. 26, 14, p. 3791-3802 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  11 Citations (Scopus)

• PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential

  Rotman, J., Otter, L. A. S. D., Bleeker, M. C. G., Samuels, S. S., Heeren, A. M., Roemer, M. G. M., Kenter, G. G., Zijlmans, H. J. M. A. A., van Trommel, N. E., de Gruijl, T. D. & Jordanova, E. S., 17 Dec 2020, In: Frontiers in immunology. 11, 596825.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  52 Citations (Scopus)
• 2019

  Cancer immunophenotyping by seven-colour multispectral imaging without tyramide signal amplification

  Ijsselsteijn, M. E., Brouwer, T. P., Abdulrahman, Z., Reidy, E., Ramalheiro, A., Heeren, A. M., Vahrmeijer, A., Jordanova, E. S., de Miranda, N. F. & Ijselstein, M., 1 Jan 2019, In: The journal of pathology. Clinical research. 5, 1, p. 3-11 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  28 Citations (Scopus)

• Efficacy of PD-1 blockade in cervical cancer is related to a CD8⁺FoxP3⁺CD25⁺ T-cell subset with operational effector functions despite high immune checkpoint levels

  Heeren, A. M., Rotman, J., Stam, A. G. M., Pocorni, N., Gassama, A. A., Samuels, S., Bleeker, M. C. G., Mom, C. H., Zijlmans, H. J. M. A. A., Kenter, G. G., Jordanova, E. S. & De Gruijl, T. D., 12 Feb 2019, In: Journal for Immunotherapy of Cancer. 7, 1, 43.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  40 Citations (Scopus)

• Neoadjuvant cisplatin and paclitaxel modulate tumor-infiltrating T cells in patients with cervical cancer

  Heeren, A. M., van Luijk, I. F., Lakeman, J., Pocorni, N., Kole, J., de Menezes, R. X., Kenter, G. G., Bosse, T., de Kroon, C. D. & Jordanova, E. S., 1 Nov 2019, In: Cancer Immunology, Immunotherapy. 68, 11, p. 1759-1767 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  38 Citations (Scopus)

• Unlocking the therapeutic potential of primary tumor-draining lymph nodes

  Rotman, J., Koster, B. D., Jordanova, E. S., Heeren, A. M. & de Gruijl, T. D., 1 Oct 2019, In: Cancer Immunology, Immunotherapy. 68, 10, p. 1681-1688 8 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  49 Citations (Scopus)
• 2018

  Indoleamine 2,3-dioxygenase expression pattern in the tumor microenvironment predicts clinical outcome in early stage cervical cancer

  Heeren, A. M., van Dijk, I., Berry, D. R. A. I., Khelil, M., Ferns, D., Kole, J., Musters, R. J. P., Thijssen, V. L., Mom, C. H., Kenter, G. G., Bleeker, M. C. G., de Gruijl, T. D. & Jordanova, E. S., 11 Jul 2018, In: Frontiers in immunology. 9, JUL, 1598.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  30 Citations (Scopus)

• The prognostic value of immune factors in the tumor microenvironment of penile squamous cell carcinoma

  Ottenhof, S. R., Djajadiningrat, R. S., Thygesen, H. H., Jakobs, P. J., Józwiak, K., Heeren, A. M., de Jong, J., Sanders, J., Horenblas, S. & Jordanova, E. S., 11 Jun 2018, In: Frontiers in immunology. 9, JUN, 1253.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  61 Citations (Scopus)

• Translating immune characteristics of metastatic tumors into therapeutic targets for cervical cancer

  Heeren, A. M., 2018, 213 p.

  Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

  Open Access
• 2017

  High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status

  Veluchamy, J. P., Heeren, A. M., Spanholtz, J., van Eendenburg, J. D. H., Heideman, D. A. M., Kenter, G. G., Verheul, H. M., van der Vliet, H. J., Jordanova, E. S. & de Gruijl, T. D., 2017, In: Cancer Immunology, Immunotherapy. 66, 1, p. 51-61

  Research output: Contribution to journal › Article › Academic › peer-review
  25 Citations (Scopus)

• HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia

  Samuels, S., Marijne Heeren, A., Zijlmans, H. J. M. A. A., Welters, M. J. P., van den Berg, J. H., Philips, D., Kvistborg, P., Ehsan, I., Scholl, S. M. E., Nuijen, B., Schumacher, T. N. M., van Beurden, M., Jordanova, E. S., Haanen, J. B. A. G., van der Burg, S. H. & Kenter, G. G., 1 Sept 2017, In: Cancer Immunology, Immunotherapy. 66, 9, p. 1163-1173 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  15 Citations (Scopus)

• MICROENVIRONMENT IN TUMOR-DRAINING LYMPH NODES FROM PATIENTS WITH HPV-RELATED VULVAR CANCER

  Zijlmans, H., Heeren, M., Samuels, S., Rotman, J., van der Velden, K., de Vijver, K. V., Kenter, G., Jordanova, E., Bleeker, M. & de Gruijl, T., Nov 2017, In: International journal of gynecological cancer. 27, p. 499-499

  Research output: Contribution to journal › Meeting Abstract › Academic

• MICROENVIRONMENT IN TUMOR-DRAINING LYMPH NODES FROM PATIENTS WITH HPV-RELATED VULVAR CANCER

  Zijlmans, H., Heeren, M., Samuels, S., Rotman, J., van der Velden, K., Van de Vijver, K., Kenter, G., Jordanova, E., Bleeker, M. & de Gruijl, T., Nov 2017, In: International journal of gynecological cancer. 27, 4, p. 1397-1397 ESGO7-130.

  Research output: Contribution to journal › Meeting Abstract › Academic
• 2016

  Classical and non-classical HLA class I aberrations in primary cervical squamous- and adenocarcinomas and paired lymph node metastases

  Ferns, D. M., Heeren, A. M., Samuels, S., Bleeker, M. C. G., de Gruijl, T. D., Kenter, G. G. & Jordanova, E. S., 15 Nov 2016, In: Journal for Immunotherapy of Cancer. 4, p. 78

  Research output: Contribution to journal › Article › Academic › peer-review
  46 Citations (Scopus)

• On the development of extragonadal and gonadal human germ cells

  Heeren, A. M., He, N., De Souza, A. F., Goercharn-Ramlal, A., Van Iperen, L., Roost, M. S., Fernandes, M. M. G., Van Der Westerlaken, L. A. J. & De Sousa Lopes, S. M. C., 15 Feb 2016, In: Biology open. 5, 2, p. 185-194 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  22 Citations (Scopus)

• Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix

  Heeren, A. M., Punt, S., Bleeker, M. C., Gaarenstroom, K. N., van der Velden, J., Kenter, G. G., de Gruijl, T. D. & Jordanova, E. S., Jul 2016, In: Modern Pathology. 29, 7, p. 753-763

  Research output: Contribution to journal › Article › Academic › peer-review
  211 Citations (Scopus)
• 2015

  CD14(+) macrophage-like cells as the linchpin of cervical cancer perpetrated immune suppression and early metastatic spread: A new therapeutic lead?

  Heeren, A. M., Kenter, G. G., Jordanova, E. S. & de Gruijl, T. D., 2015, In: Oncoimmunology. 4, 6, p. e1009296 e1009296.

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• Development of the follicular basement membrane during human gametogenesis and early folliculogenesis

  Heeren, A. M., Van Iperen, L., Klootwijk, D. B., De Melo Bernardo, A., Roost, M. S., Fernandes, M. M. G., Louwe, L. A., Hilders, C. G., Helmerhorst, F. M., Van Der Westerlaken, L. A. J. & De Sousa Lopes, S. M. C., 2015, In: BMC developmental biology. 15, 1, 4.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  63 Citations (Scopus)

• High and Interrelated Rates of PD-L1+CD14+ Antigen-Presenting Cells and Regulatory T Cells Mark the Microenvironment of Metastatic Lymph Nodes from Patients with Cervical Cancer

  Heeren, A. M., Koster, B. D., Samuels, S., Ferns, D. M., Chondronasiou, D., Kenter, G. G., Jordanova, E. S. & de Gruijl, T. D., 2015, In: Cancer immunology research. 3, 1, p. 48-58

  Research output: Contribution to journal › Article › Academic › peer-review
  87 Citations (Scopus)

• Meiotic wave adds extra asymmetry to the development of female chicken gonads

  de Melo Bernardo, A., Heeren, A. M., van Iperen, L., Fernandes, M. G., He, N., Anjie, S., Noce, T., Ramos, E. S. & de Sousa Lopes, S. M. C., Oct 2015, In: Molecular Reproduction and Development. 82, 10, p. 774-786 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  9 Citations (Scopus)

• Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area

  Heeren, A. M., de Boer, E., Bleeker, M. C. G., Musters, R. J. P., Buist, M. R., Kenter, G. G., de Gruijl, T. D. & Jordanova, E. S., 2015, In: Oncotarget. 6, 32, p. 32484-32493

  Research output: Contribution to journal › Article › Academic › peer-review
  43 Citations (Scopus)