Projects per year
Personal profile
specialisation
Bioengineering, in vitro modelling, organoids, virology
Research interests
Development of different models along the airway and gut-brain axis:
1) Gut organoids and gut epithelial cultures
2) Human airway epithelial (HAE) cultures
3) Brain organoids
4) Blood-Brain Barrier
5) Immune cell co-culture with above models
Applied for elucidating the pathogenesis of several viruses:
1) Enterovirus D68 (EV-D68)
2) Enterovirus A71 (EV-A71)
3) Parechovirus A (PeV-A1 and PeV-A3)
4) SARS-CoV-2
5) RSV
6) CMV
7) HIV
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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COMMUTE: Comorbiditiy mechanisms utlilized in health care
Pajkrt, D., Wolthers, K. & Sridhar, A.
1/12/2023 → 1/12/2027
Project: Research
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ADVOCATE: Advanced complexity in human derived organoid models for virology
Sridhar, A., Pajkrt, D., Wolthers, K. & Garcia Rodriguez, I.
1/01/2023 → 31/12/2024
Project: Research
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GUTVIBRATIONS: GUT VIrus BRain Axis Technology In OrgaNoid Science
Sridhar, A., Wolthers, K., Pajkrt, D., Calitz, C., de Sá, R. V. & Freeze, E.
1/04/2021 → 31/03/2025
Project: Research
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Focus-on-Virus: Picornavirus and HIV infection using a complex gut-brain organoid model
Sridhar, A., Pajkrt, D., Wolthers, K., Capendale, P., Johannesson, N., Depla, J. & Aknouch, I.
1/09/2020 → 1/09/2024
Project: Research
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OrganoVIR: Organoids for Virus Research - An innovative training-ETN programme
Sridhar, A., Wolthers, K., Pajkrt, D., Garcia Rodriguez, I., Moreni, G., Stroulios, G. & Masmoudi, F.
1/01/2019 → 31/12/2022
Project: Research
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Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model
Aknouch, I., Sridhar, A., Freeze, E., Giugliano, F. P., van Keulen, B. J., Romijn, M., Calitz, C., García-Rodríguez, I., Mulder, L., Wildenberg, M. E., Muncan, V., van Gils, M. J., van Goudoever, J. B., Stittelaar, K. J., Wolthers, K. C. & Pajkrt, D., 1 Dec 2022, In: Life Science Alliance. 5, 12, e202201432.Research output: Contribution to journal › Article › Academic › peer-review
Open Access9 Citations (Scopus) -
Enterovirus D68 Infection in Human Primary Airway and Brain Organoids: No Additional Role for Heparan Sulfate Binding for Neurotropism
Sridhar, A., Depla, J. A., Mulder, L. A., Karelehto, E., Brouwer, L., Kruiswijk, L., Vieira de Sá, R., Meijer, A., Evers, M. M., van Kuppeveld, F. J. M., Pajkrt, D. & Wolthers, K. C., 1 Sept 2022, In: Microbiology spectrum. 10, 5, p. e0169422Research output: Contribution to journal › Article › Academic › peer-review
Open Access11 Citations (Scopus) -
Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3
García-Rodríguez, I., van Eijk, H., Koen, G., Pajkrt, D., Sridhar, A. & Wolthers, K. C., 1 Nov 2021, In: Frontiers in cellular and infection microbiology. 11, 740662.Research output: Contribution to journal › Article › Academic › peer-review
Open Access7 Citations (Scopus) -
Assessment of the broad-spectrum host targeting antiviral efficacy of halofuginone hydrobromide in human airway, intestinal and brain organotypic models.
García-Rodríguez, I., Moreni, G., Capendale, P. E., Mulder, L., Aknouch, I., Vieira de Sá, R., Johannesson, N., Freeze, E., van Eijk, H., Koen, G., Wolthers, K. C., Pajkrt, D., Sridhar, A. & Calitz, C., 1 Feb 2024, In: Antiviral Research. 222, 105798.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease
Capendale, P. E., García-Rodríguez, I., Ambikan, A. T., Mulder, L. A., Depla, J. A., Freeze, E., Koen, G., Calitz, C., Sood, V., Vieira de Sá, R., Neogi, U., Pajkrt, D., Sridhar, A. & Wolthers, K. C., 1 Dec 2024, In: Nature communications. 15, 1, 2532.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Datasets
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Raw data TCID50. Parechovirus A infection of the intestinal epithelium
van Eijk, H. (Creator), Koen, G. (Creator), Pajkrt, D. (Creator), Sridhar, A. (Creator), Wolthers, K. (Creator) & Garcia Rodriguez, I. (Creator), University of Amsterdam / Amsterdam University of Applied Sciences, 2023
DOI: 10.21942/uva.17308958, https://uvaauas.figshare.com/articles/dataset/Raw_data_TCID50_Parechovirus_A_infection_of_the_intestinal_epithelium/17308958
Dataset
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Raw data TCID50. Parechovirus A infection of the intestinal epithelium
van Eijk, H. (Creator), Koen, G. (Creator), Pajkrt, D. (Creator), Sridhar, A. (Creator), Wolthers, K. (Creator) & Garcia Rodriguez, I. (Creator), University of Amsterdam / Amsterdam University of Applied Sciences, 2023
DOI: 10.21942/uva.17308958.v1, https://uvaauas.figshare.com/articles/dataset/Raw_data_TCID50_Parechovirus_A_infection_of_the_intestinal_epithelium/17308958/1
Dataset
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Raw data qPCR. Parechovirus A infection of the intestinal epithelium
van Eijk, H. (Creator), Koen, G. (Creator), Pajkrt, D. (Creator), Sridhar, A. (Creator), Wolthers, K. (Creator) & Garcia Rodriguez, I. (Creator), University of Amsterdam / Amsterdam University of Applied Sciences, 2023
DOI: 10.21942/uva.17294417.v1, https://uvaauas.figshare.com/articles/dataset/Raw_data_qPCR_Parechovirus_A_infection_of_the_intestinal_epithelium/17294417/1
Dataset
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Raw data qPCR. Parechovirus A infection of the intestinal epithelium
van Eijk, H. (Creator), Koen, G. (Creator), Pajkrt, D. (Creator), Sridhar, A. (Creator), Wolthers, K. (Creator) & Garcia Rodriguez, I. (Creator), University of Amsterdam / Amsterdam University of Applied Sciences, 2023
DOI: 10.21942/uva.17294417, https://uvaauas.figshare.com/articles/dataset/Raw_data_qPCR_Parechovirus_A_infection_of_the_intestinal_epithelium/17294417
Dataset
Press/Media
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De proefdiervrije toekomst krijgt al gestalte in het lab, met minibreinen en organen-op-een-chip
Adithya Sridhar, Katja C. Wolthers & Dasja Pajkrt
21/01/2022
1 Media contribution
Press/Media: Press / Media
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LMtV Episode 56: Let‘s Meet the Virologist Adithya Sridhar
Adithya Sridhar, Katja C. Wolthers & Dasja Pajkrt
20/09/2020
1 Media contribution
Press/Media: Press / Media