Projects per year
Personal profile
Research interests
To ultimately cure or prevent rheumatoid arthritis, it is critical to understand the earliest changes in the immune system that cause RA. Starting from a genome-wide expression profiling approach, this research will delineate the role of stromal cells in bone marrow, lymph node and synovial tissue in arthritis development. Results from these studies will provide innovative drug targets for preventive intervention in pre-clinical RA and identify the immunological processes that initiate RA and possibly other related chronic inflammatory diseases. In addition, molecular profiling of biomaterials is used to identify biomarkers for diagnosis, prognosis and treatment response.
specialisation
Genomics; Immunology; Translational Research; Celbiology; Rheumatology; Stromal cells; Autoimmunity; Tolerance
Education/Academic qualification
PhD, Heterogenomics of autoimmunity; Towards personalized medicine, VU University: -
2004 → 2008
Award Date: 1 Oct 2009
Keywords
- Q Science (General)
- Immunology
- R Medicine (General)
- Rheumatology
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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van Baarsen L.G.M.: Delineating the immunological processes leading to inflammatory autoimmunity
van Baarsen, L., Hahnlein, J., Ramwadhdoebe, T. & Nadafi, R.
16/03/2015 → …
Project: Research
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Molecular characterization of human lymph node stromal cells during the earliest phases of rheumatoid arthritis
Karouzakis, E., Hähnlein, J., Grasso, C., Semmelink, J. F., Tak, P. P., Gerlag, D. M., Gay, S., Ospelt, C. & van Baarsen, L. G. M., 2019, In: Frontiers in immunology. 10, AUG, Article 1863.Research output: Contribution to journal › Article › Academic › peer-review
Open Access15 Citations (Scopus) -
Brief Report: Altered Innate Lymphoid Cell Subsets in Human Lymph Node Biopsy Specimens Obtained During the At-Risk and Earliest Phases of Rheumatoid Arthritis
Rodríguez-Carrio, J., Hähnlein, J. S., Ramwadhdoebe, T. H., Semmelink, J. F., Choi, I. Y., van Lienden, K. P., Maas, M., Gerlag, D. M., Tak, P. P., Geijtenbeek, T. B. H. & van Baarsen, L. G. M., 2017, In: Arthritis & rheumatology (Hoboken, N.J.). 69, 1, p. 70-76Research output: Contribution to journal › Article › Academic › peer-review
51 Citations (Scopus) -
Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at-risk phase of autoantibody positive rheumatoid arthritis
Ramwadhdoebe, T. H., Hähnlein, J., Maijer, K. I., van Boven, L. J., Gerlag, D. M., Tak, P. P. & van Baarsen, L. G. M., 2016, In: European journal of immunology. 46, 12, p. 2812-2821Research output: Contribution to journal › Article › Academic › peer-review
24 Citations (Scopus) -
The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis
van Baarsen, L. G. M., de Hair, M. J. H., Ramwadhdoebe, T. H., Zijlstra, I. J. A. J., Maas, M., Gerlag, D. M. & Tak, P. P., 2013, In: Annals of the rheumatic diseases. 72, 8, p. 1420-1424Research output: Contribution to journal › Article › Academic › peer-review
47 Citations (Scopus) -
EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis
Gerlag, D. M., Raza, K., van Baarsen, L. G. M., Brouwer, E., Buckley, C. D., Burmester, G. R., Gabay, C., Catrina, A. I., Cope, A. P., Cornelis, F., Dahlqvist, S. R., Emery, P., Eyre, S., Finckh, A., Gay, S., Hazes, J. M., van der Helm-van Mil, A., Huizinga, T. W. J., Klareskog, L., Kvien, T. K., & 11 others, 2012, In: Annals of the rheumatic diseases. 71, 5, p. 638-641Research output: Contribution to journal › Review article › Academic › peer-review
333 Citations (Scopus)