Projects per year
Personal profile
Research interests
Our primary goal is to pioneer novel immune based preventive and curative interventions in oncology, as we strongly believe that prevention and cure are better than any palliative treatment. Our research focusses on the application of T-cell induction in prophylactic and curative oncologic treatment settings, targeting tumour specific neo-antigens. Among other activities, this involves the search for neo-antigens in mismatch repair deficient colorectal cancer patients. For that purpose my group leads a KWF granted consortium and a clinical trial sponsored by pharma . In addition my research group explores novel ways to combine ICB treatment with radiotherapy , also in the context of investigator initiated a clinical trials.
specialisation
Medical oncology, immuno oncology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SKMS Project ‘Pilot ter optimalisatie van de niertumorregistratie’
Zondervan, P., Bins, A. D., van der Meer, R. W. & Bochove-Overgaauw, D.
Project: Other
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Rapid DNA vaccination against Burkholderia pseudomallei flagellin by tattoo or intranasal application
Lankelma, J. M., Wagemakers, A., Birnie, E., Haak, B. W., Trentelman, J. J. A., Weehuizen, T. A. F., Ersöz, J., Roelofs, J. J. T. H., Hovius, J. W., Wiersinga, W. J. & Bins, A. D., 2017, In: Virulence. 8, 8, p. 1683-1694Research output: Contribution to journal › Article › Academic › peer-review
12 Citations (Scopus) -
A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression
Bins, A. D., Jorritsma, A., Wolkers, M. C., Hung, C-F., Wu, T-C., Schumacher, T. N. M. & Haanen, J. B. A. G., 2005, In: Nature medicine. 11, 8, p. 899-904Research output: Contribution to journal › Article › Academic › peer-review
148 Citations (Scopus) -
Rapid outer-surface protein C DNA tattoo vaccination protects against Borrelia afzelii infection
Wagemakers, A., Mason, L. M. K., Oei, A., de Wever, B., van der Poll, T., Bins, A. D. & Hovius, J. W. R., 2014, In: Gene therapy. 21, 12, p. 1051-1057Research output: Contribution to journal › Article › Academic › peer-review
17 Citations (Scopus) -
Visualization of immediate immune responses to pioneer metastatic cells in the lung
Headley, M. B., Bins, A., Nip, A., Roberts, E. W., Looney, M. R., Gerard, A. & Krummel, M. F., 2016, In: NATURE. 531, 7595, p. 513-517Research output: Contribution to journal › Article › Academic › peer-review
309 Citations (Scopus) -
In vivo antigen stability affects DNA vaccine immunogenicity
Bins, A. D., Wolkers, M. C., van den Boom, M. D., Haanen, J. B. A. G. & Schumacher, T. N. M., 2007, In: Journal of immunology (Baltimore, Md.. 179, 4, p. 2126-2133Research output: Contribution to journal › Article › Academic › peer-review
37 Citations (Scopus)
Datasets
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Additional file 1 of Efficacy, safety and biomarker analysis of durvalumab in patients with mismatch-repair deficient or microsatellite instability-high solid tumours
Geurts, B. S. (Creator), Battaglia, T. W. (Creator), van Berge Henegouwen, J. M. (Creator), Zeverijn, L. J. (Creator), de Wit, G. F. (Creator), Hoes, L. R. (Creator), van der Wijngaart, H. (Creator), van der Noort, V. (Creator), Roepman, P. (Creator), de Leng, W. W. J. (Creator), Jansen, A. M. L. (Creator), Opdam, F. L. (Creator), de Jonge, M. J. A. (Creator), Cirkel, G. A. (Creator), Labots, M. (Creator), Hoeben, A. (Creator), Kerver, E. D. (Creator), Bins, A. D. (Creator), Erdkamp, F. G. L. (Creator), van Rooijen, J. M. (Creator), Houtsma, D. (Creator), Hendriks, M. P. (Creator), de Groot, J. B. (Creator), Verheul, H. M. W. (Creator), Gelderblom, H. (Creator), Voest, E. E. (Creator), Battaglia, T. W. (Creator), de Jonge, M. J. A. (Creator) & Erdkamp, F. G. L. (Creator), Figshare, 2023
DOI: 10.6084/m9.figshare.22625615.v1, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Efficacy_safety_and_biomarker_analysis_of_durvalumab_in_patients_with_mismatch-repair_deficient_or_microsatellite_instability-high_solid_tumours/22625615/1
Dataset
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Additional file 1 of Efficacy, safety and biomarker analysis of durvalumab in patients with mismatch-repair deficient or microsatellite instability-high solid tumours
Geurts, B. S. (Creator), Battaglia, T. W. (Creator), van Berge Henegouwen, J. M. (Creator), Zeverijn, L. J. (Creator), de Wit, G. F. (Creator), Hoes, L. R. (Creator), van der Wijngaart, H. (Creator), van der Noort, V. (Creator), Roepman, P. (Creator), de Leng, W. W. J. (Creator), Jansen, A. M. L. (Creator), Opdam, F. L. (Creator), de Jonge, M. J. A. (Creator), Cirkel, G. A. (Creator), Labots, M. (Creator), Hoeben, A. (Creator), Kerver, E. D. (Creator), Bins, A. D. (Creator), Erdkamp, F. G. L. (Creator), van Rooijen, J. M. (Creator), Houtsma, D. (Creator), Hendriks, M. P. (Creator), de Groot, J. B. (Creator), Verheul, H. M. W. (Creator), Gelderblom, H. (Creator), Voest, E. E. (Creator), Battaglia, T. W. (Creator), de Jonge, M. J. A. (Creator) & Erdkamp, F. G. L. (Creator), Figshare, 2023
DOI: 10.6084/m9.figshare.22625615, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Efficacy_safety_and_biomarker_analysis_of_durvalumab_in_patients_with_mismatch-repair_deficient_or_microsatellite_instability-high_solid_tumours/22625615
Dataset