A.G.M. Stam

Research output

Research output per year 2000 2003 2013 2017 2022

• 28 Article
• 2 Meeting Abstract
• 1 Comment/Letter to the editor

Research output per year

Research output per year

Search results

• 2022

  Local delivery of low-dose anti-CTLA-4 to the melanoma lymphatic basin leads to systemic Treg reduction and effector T cell activation

  van Pul, K. M., Notohardjo, J. C. L., Fransen, M. F., Koster, B. D., Stam, A. G. M., Chondronasiou, D., Lougheed, S. M., Bakker, J., Kandiah, V., van den Tol, M. P., Jooss, K., Vuylsteke, R. J. C. L. M., van den Eertwegh, A. J. M. & de Gruijl, T. D., 15 Jul 2022, In: Science immunology. 7, 73, p. eabn8097 eabn8097.

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)
• 2021

  A bispecific antibody antagonizes prosurvival CD40 signaling and promotes Vγ9Vδ2 T cell-mediated antitumor responses in human B-cell malignancies

  de Weerdt, I., Lameris, R., Scheffer, G. L., Vree, J., de Boer, R., Stam, A. G., van de Ven, R., Levin, M-D., Pals, S. T., Roovers, R. C., Parren, P. W. H. I., de Gruijl, T. D., Kater, A. P. & van der Vliet, H. J., 1 Jan 2021, In: Cancer immunology research. 9, 1, p. 50-61 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)
• 2020

  Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8+ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma

  Rotman, J., Heeren, A. M., Gassama, A. A., Lougheed, S. M., Pocorni, N., Stam, A. G. M., Bleeker, M. C. G., Zijlmans, H. J. M. A. A., Mom, C. H., Kenter, G. G., Jordanova, E. S. & de Gruijl, T. D., 15 Jul 2020, In: Clinical Cancer Research. 26, 14, p. 3791-3802 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  11 Citations (Scopus)
• 2019

  Efficacy of PD-1 blockade in cervical cancer is related to a CD8⁺FoxP3⁺CD25⁺ T-cell subset with operational effector functions despite high immune checkpoint levels

  Heeren, A. M., Rotman, J., Stam, A. G. M., Pocorni, N., Gassama, A. A., Samuels, S., Bleeker, M. C. G., Mom, C. H., Zijlmans, H. J. M. A. A., Kenter, G. G., Jordanova, E. S. & De Gruijl, T. D., 12 Feb 2019, In: Journal for Immunotherapy of Cancer. 7, 1, 43.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  40 Citations (Scopus)

• Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation

  Scheffer, H. J., Stam, A. G. M., Geboers, B., Vroomen, L. G. P. H., Ruarus, A., de Bruijn, B., van den Tol, M. P., Kazemier, G., Meijerink, M. R. & de Gruijl, T. D., 2 Nov 2019, In: Oncoimmunology. 8, 11, 1652532.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  65 Citations (Scopus)
• 2018

  A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells

  de Bruin, R. C. G., Veluchamy, J. P., Lougheed, S. M., Schneiders, F. L., Lopez-Lastra, S., Lameris, R., Stam, A. G., Sebestyen, Z., Kuball, J., Molthoff, C. F. M., Hooijberg, E., Roovers, R. C., Santo, J. P. D., van Bergen en Henegouwen, P. M. P., Verheul, H. M. W., de Gruijl, T. D. & van der Vliet, H. J., 2 Jan 2018, In: Oncoimmunology. 7, 1, e1375641.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  63 Citations (Scopus)

• Improved Induction of Anti-Melanoma T Cells by Adenovirus-5/3 Fiber Modification to Target Human DCs

  Chondronasiou, D., Eisden, T-J. T. H. D., Stam, A. G. M., Matthews, Q. L., Icyuz, M., Hooijberg, E., Dmitriev, I., Curiel, D. T., de Gruijl, T. D. & van de Ven, R., 18 Jul 2018, In: Vaccines. 6, 3

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)
• 2017

  Ablation of Locally Advanced Pancreatic Cancer with Percutaneous Irreversible Electroporation: Results of the Phase I/II PANFIRE Study: Results of the Phase I/II PANFIRE Study

  Scheffer, H. J., Vroomen, L. G. P. H., de Jong, M. C., Melenhorst, M. C. A. M., Zonderhuis, B. M., Daams, F., Vogel, J. A., Besselink, M. G. H., van Kuijk, C., Witvliet, J., de van der Schueren, M. A. E., de Gruijl, T. D., Stam, A. G. M., van den Tol, P. M. P., van Delft, F., Kazemier, G. & Meijerink, M. R., 2017, In: Radiology. 282, 2, p. 585-597

  Research output: Contribution to journal › Article › Academic › peer-review
  107 Citations (Scopus)

• High PD-1 expression on regulatory and effector T cells in lung cancer draining lymph nodes

  Van de Ven, R., Niemeijer, A-L. N., Stam, A. G., Hashemi, S. M., Slockers, C. G., Daniels, J. M., Thunnissen, E., Smit, E. F., de Gruijl, T. D. & de langen, A. J., Jul 2017, In: Cancer research. 77

  Research output: Contribution to journal › Meeting Abstract › Academic

• High PD-1 expression on regulatory and effector T-cells in lung cancer draining lymph nodes

  van de Ven, R., Niemeijer, A-L. N., Stam, A. G. M., Hashemi, S. M. S., Slockers, C. G., Daniels, J. M., Thunnissen, E., Smit, E. F., de Gruijl, T. D. & de Langen, A. J., 1 Apr 2017, In: ERS Monograph. 3, 2, 00110-2016.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  24 Citations (Scopus)

• Long survival of patients with locally advanced breast cancer on combined neoadjuvant chemotherapy and immune potentiation: Modern lessons from an old study

  Pohlmann, P. R., van Cruijsen, H., Stam, A. G. M., Lougheed, S. M., van den Eertwegh, A. J. M., Hoekman, K., Scheper, R., Buter, J., van der Hoeven, J. J. M., van der Wall, E., Pinedo, H. M. & de Gruij, T. D., Feb 2017, In: Cancer research. 77

  Research output: Contribution to journal › Article › Academic › peer-review

• Prevention of V gamma 9V delta 2 T cell activation by a V gamma 9V delta 2 TCR nanobody (vol 198, pg 308, 2017)

  de Bruin, R. C. G., Stam, A. G. M., Vangone, A., Henegouwen, P. M. P. V. B. E., Verheul, H. M. W., Sebestyen, Z., Kuball, J., Bonvin, A. M. J. J., de Gruijl, T. D. & van der Vliet, H. J., 1 May 2017, In: Journal of Immunology. 198, 9, p. 3759-3759

  Research output: Contribution to journal › Article › Academic › peer-review

• Prevention of Vγ9Vδ2 T cell activation by a Vγ9Vδ2 TCR nanobody

  De Bruin, R. C. G., Stam, A. G. M., Vangone, A., Van Bergen En Henegouwen, P. M. P., Verheul, H. M. W., Sebestyén, Z., Kuball, J., Bonvin, A. M. J. J., De Gruijl, T. D. & Van Der Vliet, H. J., 1 Jan 2017, In: Journal of Immunology. 198, 1, p. 308-317 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  8 Citations (Scopus)
• 2016

  Highly specific and potently activating V gamma 9V delta 2-T cell specific nanobodies for diagnostic and therapeutic applications

  de Bruin, R. C. G., Lougheed, S. M., van der Kruk, L., Stam, A. G., Hooijberg, E., Roovers, R. C., Henegouwen, P. M. P. V. B. E., Verheul, H. M. W., de Gruijl, T. D. & van der Vliet, H. J., Aug 2016, In: Clinical Immunology. 169, p. 128-138

  Research output: Contribution to journal › Article › Academic › peer-review
  27 Citations (Scopus)
• 2014

  Induction of dendritic cell maturation in the skin microenvironment by soluble factors derived from colon carcinoma

  Lindenberg, J. J., van de Ven, R., Oosterhoff, D., Sombroek, C. C., Lougheed, S. M., Stam, A. G. M., Koenen, H. J. P. M., van den Eertwegh, A. J. M., Scheper, R. J. & de Gruijl, T. D., 2014, In: Human vaccines & immunotherapeutics. 10, 6, p. 1622-1632

  Research output: Contribution to journal › Article › Academic › peer-review
  4 Citations (Scopus)

• Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab

  Santegoets, S. J. A. M., Stam, A. G. M., Lougheed, S. M., Gall, H., Jooss, K., Sacks, N., Hege, K., Lowy, I., Scheper, R. J., Gerritsen, W. R., van den Eertwegh, A. J. M. & de Gruijl, T. D., 2014, In: Journal for Immunotherapy of Cancer. 2, 31.

  Research output: Contribution to journal › Article › Academic › peer-review
  89 Citations (Scopus)
• 2013

  IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation

  Lindenberg, J. J., Oosterhoff, D., Sombroek, C. C., Lougheed, S. M., Hooijberg, E., Stam, A. G. M., Santegoets, S. J. A. M., Tijssen, H. J., Buter, J., Pinedo, H. M., van den Eertwegh, A. J. M., Scheper, R. J., Koenen, H. J. P. M., van de Ven, R. & de Gruijl, T. D., 2013, In: PLOS ONE. 8, 7, e70237.

  Research output: Contribution to journal › Article › Academic › peer-review
  29 Citations (Scopus)

• IL-21 promotes the expansion of CD27+CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells

  Santegoets, S. J. A. M., Turksma, A. W., Suhoski, M. M., Stam, A. G. M., Albelda, S. M., Hooijberg, E., Scheper, R. J., van den Eertwegh, A. J. M., Gerritsen, W. R., Powell, D. J. J., June, C. H. & de Gruijl, T. D., 2013, In: Journal of translational medicine. 11, p. 37-37

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  69 Citations (Scopus)

• Priming of PRAME- and WT1-specific CD8(+) T cells in healthy donors but not in AML patients in complete remission: Implications for immunotherapy

  van den Ancker, W., Ruben, J. M., Westers, T. M., Wulandari, D., Bontkes, H. J., Hooijberg, E., Stam, A. G. M., Santegoets, S. J. A. M., Ossenkoppele, G. J., de Gruijl, T. D. & van de Loosdrecht, A. A., 2013, In: Oncoimmunology. 2, 4, e23971.

  Research output: Contribution to journal › Article › Academic › peer-review
  17 Citations (Scopus)

• T cell profiling reveals high CD4(+)CTLA-4(+) T cell frequency as dominant predictor for survival after Prostate GVAX/ipilimumab treatment

  Santegoets, S. J. A. M., Stam, A. G. M., Lougheed, S. M., Gall, H., Scholten, P. E. T., Reijm, M., Jooss, K., Sacks, N., Hege, K., Lowy, I., Cuillerot, J. M., von Blomberg, B. M. E., Scheper, R. J., van den Eertwegh, A. J. M., Gerritsen, W. R. & de Gruijl, T. D., 2013, In: Cancer immunology and immunotherapy. 62, 2, p. 245-256

  Research output: Contribution to journal › Article › Academic › peer-review
  76 Citations (Scopus)
• 2012

  Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial

  van den Eertwegh, A. J. M., Versluis, J. P., van den Berg, H. P., Santegoets, S. J. A. M., van Moorselaar, R. J. A., van der Sluis, T. M., Gall, H. E., Harding, T. C., Jooss, K., Lowy, I., Pinedo, H. M., Scheper, R. J., Stam, A. G. M., von Blomberg, B. M. E., de Gruijl, T. D., Hege, K., Sacks, N. & Gerritsen, W. R., 2012, In: lancet oncology. 13, 5, p. 509-517

  Research output: Contribution to journal › Article › Academic › peer-review
  308 Citations (Scopus)
• 2010

  4-1BB-mediated expansion affords superior detection of in vivo primed effector memory CD8(+) T cells from melanoma sentinel lymph nodes

  Sluijter, B. J. R., van den Hout, M. F. C. M., Stam, A. G. M., Lougheed, S. M., Suhoski, M. M., van den Eertwegh, A. J. M., van den Tol, M. P., van Leeuwen, P. A. M., Meijer, S., Scheper, R. J., June, C. H., de Gruijl, T. D. & Santegoets, S. J. A. M., 2010, In: Clinical Immunology. 137, 2, p. 221-233

  Research output: Contribution to journal › Article › Academic › peer-review
  18 Citations (Scopus)

• T Cell Activation, PSMA Seroconversion and Increased Th17 Rates are Associated with Favorable Clinical Outcome in Prostate Cancer Patients Treated with Prostate GVAX and Anti-CTLA4 Immunotherapy

  Santegoets, S. J. A. M., van den Eertwegh, A. J. M., Stam, A. G. M., Scheper, R. J., Lougheed, S. M., Scholten, P. E., von Blomberg, B. M. E., Gall, H., Jooss, K., Sacks, N., Harding, T., Hege, K., Lowy, I., Gerritsen, W. R. & de Gruijl, T. D., 2010, In: Journal of Immunotherapy. 33, 8, p. 918-919

  Research output: Contribution to journal › Meeting Abstract › Other research output
• 2007

  Defective differentiation of myeloid and plasmacytoid dendritic cells in advanced cancer patients is not normalized by tyrosine kinase inhibition of the vascular endothelial growth factor receptor

  Van Cruijsen, H., Hoekman, K., Stam, A. G. M., Van Den Eertwegh, A. J. M., Kuenen, B. C., Scheper, R. J., Giaccone, G. & De Gruijl, T. D., 1 Dec 2007, In: Clinical and Developmental Immunology. 2007, 17315.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  24 Citations (Scopus)
• 2005

  Circulating Valpha24+Vbeta11+ NKT cell numbers and dendritic cell CD1d expression in hepatitis C virus infected patients

  van der Vliet, H. J. J., Molling, J. W., von Blomberg, B. M. E., Kölgen, W., Stam, A. G., de Gruijl, T. D., Mulder, C. J., Janssen, H. L. A., Nishi, N., van den Eertwegh, A. J. M., Scheper, R. J. & van Nieuwkerk, C. J. M., Feb 2005, In: Clinical Immunology. 114, 2, p. 183-189 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  38 Citations (Scopus)
• 2003

  Erratum: Rapid generation of antigen-presenting cells from leukaemic blasts in acute myeloid leukaemia (Cancer Immunology, Immunotherapy (2003) 52 (17-27))

  Westers, T. M., Stam, A. G. M., Scheper, R. J., Regelink, J. C., Nieuwint, A. W. M., Schuurhuis, G. J., Van De Loosdrecht, A. A. & Ossenkoppele, G. J., 1 Aug 2003, In: Cancer Immunology, Immunotherapy. 52, 8, p. 523-524 2 p.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic

  Open Access

• Rapid generation of antigen-presenting cells from leukaemic blasts in acute myeloid leukaemia

  Westers, T. M., Stam, A. G. M., Scheper, R. J., Regelink, J. C., Nieuwint, A. W. M., Schuurhuis, G. J., Van De Loosdrecht, A. A. & Ossenkoppele, G. J., 1 Jan 2003, In: Cancer Immunology, Immunotherapy. 52, 1, p. 17-27 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  55 Citations (Scopus)

• Serum-free generation of antigen presenting cells from acute myeloid leukaemic blasts for active specific immunisation

  Houtenbos, I., Westers, T. M., Stam, A. G. M., De Gruijl, T. D., Scheper, R. J., Ossenkoppele, G. J. & Van De Loosdrecht, A. A., 1 Jul 2003, In: Cancer Immunology, Immunotherapy. 52, 7, p. 455-462 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  33 Citations (Scopus)
• 2002

  Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation

  Sombroek, C. C., Stam, A. G. M., Masterson, A. J., Lougheed, S. M., Schakel, M. J. A. G., Meijer, C. J. L. M., Pinedo, H. M., Van den Eertwegh, A. J. M., Scheper, R. J. & De Gruijl, T. D., 1 May 2002, In: Journal of Immunology. 168, 9, p. 4333-4343 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  177 Citations (Scopus)

• Up-regulation of drug resistance-related vaults during dendritic cell development

  Schroeijers, A. B., Reurs, A. W., Scheffer, G. L., Stam, A. G. M., De Jong, M. C., Rustemeyer, T., Wiemer, E. A. C., De Gruijl, T. D. & Scheper, R. J., 15 Feb 2002, In: Journal of Immunology. 168, 4, p. 1572-1578 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  49 Citations (Scopus)
• 2000

  Skin tests predict survival after autologous tumor cell vaccination in metastatic melanoma: Experience in 81 patients

  Baars, A., Claessen, A. M. E., Van den Eertwegh, A. J. M., Gall, H. E., Stam, A. G. M., Meijer, S., Giaccone, G., Meijer, C. J. L. M., Scheper, R. J., Wagstaff, J., Vermorken, J. B. & Pinedo, H. M., 2000, In: Annals of Oncology. 11, 8, p. 965-970 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  55 Citations (Scopus)