Allison McDonald

MSc

20212023

Research activity per year

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Personal profile

specialisation

Addiction, Animal models, Behavioural neuroscience, Chemogenetics, Fiber photometry

Research interests

A core component of Alcohol use disorder (AUD) is alcohol use despite negative consequences. The brain areas and neural circuits underlying this aspect of AUD are not well understood. My research aims to describe the neural circuits underlying compulsive alcohol use in a pre-clinical model. 

Through the use of techniques such as cFos immunohistochemistry and retrograde tracing, we have been able to identify neural circuits whose activity is associated with compulsive alcohol use. We are now using chemogenetics (DREADDs) and fiber photometry (in-vivo calcium imaging) to manipulate and monitor the activity of these circuits to gain a greater understanding of these brain areas that are responsible for promoting alcohol use despite negative consequences. These findings will add to our understanding of AUD as a brain disorder, and may even help us identify novel AUD treatments. 

In my research, I also integrate the use of open-source quantitative and automatic data analysis approaches. I am implementing the use of automatic quantitative behavioural video analysis, and an open-source histology analysis pipeline for brain-wide automatic cell detection.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Collaborations and top research areas from the last five years

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