Projects per year
Personal profile
Research interests
Understanding the occurrence and role of epigenetic marks in inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.
specialisation
Bioinformatics
Education/Academic qualification
Master, Molecular and Cellular Life Sciences, Utrecht University: Faculty of Science
1 Sept 2012 → 31 Mar 2015
Award Date: 31 Mar 2015
Bachelor, University College Utrecht
1 Sept 2009 → 31 Aug 2012
Award Date: 31 Aug 2012
External positions
Bioinformatician, OmiQuant
1 Aug 2019 → …
PhD student, R&D GlaxoSmithKline
1 Aug 2015 → 31 Aug 2019
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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DNA methylation markers to predict treatment success of biologicals in Crohn’s disease.
1/01/2023 → 31/12/2026
Project: Research
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de Jonge W.J.: Gastro-Intestinal diseases
de Jonge, W., Heinsbroek, S., Seppen, J., van den Wijngaard, R., Zhao, J., van Leeuwen - Hilbers, F., Verseijden, C., Welting, O., Botschuijver, S., Brinkman, D., Chen, H., Dhawan, S., Duijvis, N., Ghiboub, M., ten Hove, A., de Krijger, M., Li Yim, A., Loring, S., Luque Martin, R., Peters, E., Schilderink, R., van Thiel, I., de Vries, L., Willemze, R. & Zhao, J.
1/09/2008 → …
Project: Research
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Mannens M.M.A.M.: Clinical Molecular Genetics with emphasis on cardiogenetics and growth malformations
Ensink, J., Krzyzewska, I., Li Yim, A., Mannens, M., Alders, M., Bikker, H., Henneman, P., van Koningsbruggen, S., Lekanne Dit Deprez, R., Lombardi, P., Mook, O., Motazacker, M. & Redeker, B.
1/02/2007 → …
Project: Research
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EPIC-CD
Li Yim, A., Hageman, I., Joustra, V., Satsangi, J., Henneman, P., de Jonge, W. & D' Haens, G.
1/01/2019 → 1/01/2023
Project: Research
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EPIMAC: The next generation epigenetic medicine for inflammation
Li Yim, A., Chen, H., Ghiboub, M., Luque Martin, R., Loring, S., Elfiky, A., Henneman, P., de Jonge, W., de Winther, M. & Prinjha, R. K.
1/01/2015 → 30/06/2019
Project: Research
Research output
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Expression Quantitative Trait Methylation Analysis Identifies Whole Blood Molecular Footprint in Fetal Alcohol Spectrum Disorder (FASD)
Krzyzewska, I. M., Lauffer, P., Mul, A. N., van der Laan, L., Yim, A. Y. F. L., Cobben, J. M., Niklinski, J., Chomczyk, M. A., Smigiel, R., Mannens, M. M. A. M. & Henneman, P., 1 Apr 2023, In: International journal of molecular sciences. 24, 7, 6601.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Histology and transcriptome insights into the early processes of intestinal anastomotic healing: a rat model
van Helsdingen, C. P. M., Wildeboer, A. C. L., Zafeiropoulou, K., Jongen, A. C. H. M., Bosmans, J. W. A. M., Gallé, C., Hakvoort, T. B. M., Gijbels, M. J. J., de Jonge, W. J., Bouvy, N. D., Li Yim, A. Y. F. & Derikx, J. P. M., 1 Oct 2023, In: BJS Open. 7, 5, zrad099.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel Disease
Joustra, V., Li Yim, A. Y. F., Hageman, I., Levin, E., Adams, A., Satsangi, J., de Jonge, W. J., Henneman, P. & D'Haens, G., 1 Jan 2023, In: Cellular and Molecular Gastroenterology and Hepatology. 15, 4, p. 869-885 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients
Hageman, I., Mol, F., Atiqi, S., Joustra, V., Sengul, H., Henneman, P., Visman, I., Hakvoort, T., Nurmohamed, M., Wolbink, G., Levin, E., Li Yim, A. Y. F., D’Haens, G. & de Jonge, W. J., 2023, In: Frontiers in immunology. 14, 1303231.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Peripheral blood DNA methylation signatures and response to tofacitinib in moderate-to-severe ulcerative colitis
Joustra, V., Li Yim, A. Y. F., van Gennep, S., Hageman, I., de Waard, T., Levin, E., Lauffer, P., de Jonge, W. J., Henneman, P., Löwenberg, M. & D'Haens, G. R., 1 Aug 2023, (E-pub ahead of print) In: Journal of Crohn's & Colitis.Research output: Contribution to journal › Article › Academic › peer-review
Datasets
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Prenatal NeuN+ neurons of Down Syndrome display aberrant integrative DNA methylation and gene expression profiles. Supplementary data
Henneman, P. (Creator), Mul, A. N. (Creator), Li Yim, A. (Creator), Krzyzewska, I. (Creator), Alders, M. (Creator), Adelia, A. (Creator), Mizee, M. R. (Creator) & Mannens, M. (Creator), Future Science Group, 2022
DOI: 10.25402/epi.19290170, https://future-science-group.figshare.com/articles/dataset/Prenatal_NeuN_neurons_of_Down_Syndrome_display_aberrant_integrative_DNA_methylation_and_gene_expression_profiles_Supplementary_data/19290170
Dataset
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Additional file 10 of Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
Ghiboub, M. (Creator), Koster, J. (Creator), Craggs, P. D. (Creator), Li Yim, A. (Creator), Shillings, A. (Creator), Hutchinson, S. (Creator), Bingham, R. P. (Creator), Gatfield, K. (Creator), Hageman, I. L. (Creator), Yao, G. (Creator), O’Keefe, H. P. (Creator), Coffin, A. (Creator), Patel, A. (Creator), Sloan, L. A. (Creator), Mitchell, D. J. (Creator), Hayhow, T. G. (Creator), Lunven, L. (Creator), Watson, R. J. (Creator), Blunt, C. E. (Creator), Harrison, L. A. (Creator), Bruton, G. (Creator), Kumar, U. (Creator), Hamer, N. (Creator), Spaull, J. R. (Creator), Zwijnenburg, D. A. (Creator), Welting, O. (Creator), Hakvoort, T. B. M. (Creator), te Velde, A. (Creator), van Limbergen, J. (Creator), Henneman, P. (Creator), Prinjha, R. K. (Creator), de Winther, M. (Creator), Harker, N. R. (Creator), Tough, D. F. (Creator), de Jonge, W. (Creator), Coffin, A. (Creator), van Limbergen, J. (Creator) & Harker, N. R. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20521093.v1, https://springernature.figshare.com/articles/dataset/Additional_file_10_of_Modulation_of_macrophage_inflammatory_function_through_selective_inhibition_of_the_epigenetic_reader_protein_SP140/20521093/1
Dataset
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Additional file 15 of Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
Ghiboub, M. (Creator), Koster, J. (Creator), Craggs, P. D. (Creator), Li Yim, A. (Creator), Shillings, A. (Creator), Hutchinson, S. (Creator), Bingham, R. P. (Creator), Gatfield, K. (Creator), Hageman, I. L. (Creator), Yao, G. (Creator), O’Keefe, H. P. (Creator), Coffin, A. (Creator), Patel, A. (Creator), Sloan, L. A. (Creator), Mitchell, D. J. (Creator), Hayhow, T. G. (Creator), Lunven, L. (Creator), Watson, R. J. (Creator), Blunt, C. E. (Creator), Harrison, L. A. (Creator), Bruton, G. (Creator), Kumar, U. (Creator), Hamer, N. (Creator), Spaull, J. R. (Creator), Zwijnenburg, D. A. (Creator), Welting, O. (Creator), Hakvoort, T. B. M. (Creator), te Velde, A. (Creator), van Limbergen, J. (Creator), Henneman, P. (Creator), Prinjha, R. K. (Creator), de Winther, M. (Creator), Harker, N. R. (Creator), Tough, D. F. (Creator), de Jonge, W. (Creator), Coffin, A. (Creator), van Limbergen, J. (Creator) & Harker, N. R. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20521114.v1, https://springernature.figshare.com/articles/dataset/Additional_file_15_of_Modulation_of_macrophage_inflammatory_function_through_selective_inhibition_of_the_epigenetic_reader_protein_SP140/20521114/1
Dataset
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Additional file 14 of Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
Ghiboub, M. (Creator), Koster, J. (Creator), Craggs, P. D. (Creator), Li Yim, A. (Creator), Shillings, A. (Creator), Hutchinson, S. (Creator), Bingham, R. P. (Creator), Gatfield, K. (Creator), Hageman, I. L. (Creator), Yao, G. (Creator), O’Keefe, H. P. (Creator), Coffin, A. (Creator), Patel, A. (Creator), Sloan, L. A. (Creator), Mitchell, D. J. (Creator), Hayhow, T. G. (Creator), Lunven, L. (Creator), Watson, R. J. (Creator), Blunt, C. E. (Creator), Harrison, L. A. (Creator), Bruton, G. (Creator), Kumar, U. (Creator), Hamer, N. (Creator), Spaull, J. R. (Creator), Zwijnenburg, D. A. (Creator), Welting, O. (Creator), Hakvoort, T. B. M. (Creator), te Velde, A. (Creator), van Limbergen, J. (Creator), Henneman, P. (Creator), Prinjha, R. K. (Creator), de Winther, M. (Creator), Harker, N. R. (Creator), Tough, D. F. (Creator), de Jonge, W. (Creator), Coffin, A. (Creator), van Limbergen, J. (Creator) & Harker, N. R. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20521111, https://springernature.figshare.com/articles/dataset/Additional_file_14_of_Modulation_of_macrophage_inflammatory_function_through_selective_inhibition_of_the_epigenetic_reader_protein_SP140/20521111
Dataset
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Additional file 7: Table S5. of Peripheral blood methylation profiling of female Crohn’s disease patients
Li Yim, A. (Contributor), Duijvis, N. W. (Creator), Zhao, J. (Creator), de Jonge, W. (Contributor), D' Haens, G. (Creator), Mannens, M. (Creator), Mul, A. N. P. M. (Creator), te Velde, A. (Contributor), Henneman, P. (Creator), D' Haens, G. (Creator) & Mannens, M. (Creator), Figshare, 2016
DOI: 10.6084/m9.figshare.c.3620078_d1.v1, https://springernature.figshare.com/articles/dataset/Additional_file_7_Table_S5_of_Peripheral_blood_methylation_profiling_of_female_Crohn_s_disease_patients/4391117/1
Dataset