Projects per year
Personal profile
Specialisation
Macrophages, Cardiovascular Disease, Atherosclerosis, Epigenetics
Research interests
In our lab we study macrophage epigenetic processes in cardiovascular disease with a focus on atherosclerosis. Epigenetic processes are critical regulators of the immune system and are emerging as targets for diagnosis and interventions. Also in monocytes and macrophages epigenetic pathways are important in regulating responses and cellular phenotype and thereby impact on disease development.
I am highly interested in the the Polycomb Repressive Complex 2 (PRC2) in macrophages and atherosclerosis and my work integrates fundamental research questions with translational applications both in vitro and in vivo.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 2 Active
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Lutgens E.: The immune system in atherosclerosis and obesity
Aarts, S. A. B. M., Baardman, J., van den Berg, S. M., Braster, Q., Jansen, M. F., Kusters, P. J. H., van Leent, M. M. T., Neele, A. E., Smeets, E., Lutgens, E., Silvestre Roig, C., van Tiel, C. M., Beckers, L., den Toom, M. M., Gerdes, N. & Legein, B.
1/12/2011 → …
Project: Research
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de Winther M.P.J.: Macrophage regulation in atherosclerosis
Aarts, S. A. B. M., Baardman, J., van den Berg, S. M., Chen, H. J. J., Ghiboub, M., Kusters, P. J. H., Loring, S., Luque Martin, R., Neele, A. E., Ruizendaal, E., Schilderink, R., Smeets, E., de Winther, M., Gijbels, M. J. J., Van den Bossche, J., van der Velden, S., van der Vorst, E. & Wolfs, I.
1/10/2011 → …
Project: Research
Research output
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Myeloid Ezh2 Deficiency Limits Atherosclerosis Development
Neele, A. E., Chen, H. J., Gijbels, M. J. J., van der Velden, S., Hoeksema, M. A., Boshuizen, M. C. S., Van den Bossche, J., Tool, A. T., Matlung, H. L., van den Berg, T. K., Lutgens, E. & de Winther, M. P. J., 26 Jan 2021, In: Frontiers in immunology. 11, 594603.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus) -
Targeting epigenetics as atherosclerosis treatment: an updated view
Neele, A. E., Willemsen, L., Chen, H-J., Dzobo, K. E. & de Winther, M. P. J., 1 Dec 2020, In: Current opinion in lipidology. 31, 6, p. 324-330 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access8 Citations (Scopus) -
PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia
Bernelot Moens, S. J., Neele, A. E., Kroon, J., Van Der Valk, F. M., Van Den Bossche, J., Hoeksema, M. A., Hoogeveen, R. M., Schnitzler, J. G., Baccara-Dinet, M. T., Manvelian, G., De Winther, M. P. J. & Stroes, E. S. G., 2017, In: European Heart journal. 38, 20, p. 1584-1593 10 p.Research output: Contribution to journal › Article › Academic › peer-review
113 Citations (Scopus) -
Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites
Dekkers, K. F., Neele, A. E., Jukema, J. W., Heijmans, B. T. & de Winther, M. P. J., 2019, In: Epigenetics & Chromatin. 12, 1, 34.Research output: Contribution to journal › Article › Academic › peer-review
Open Access23 Citations (Scopus) -
Myeloid Kdm6b deficiency results in advanced atherosclerosis
Neele, A. E., Gijbels, M. J. J., van der Velden, S., Hoeksema, M. A., Boshuizen, M. C. S., Prange, K. H. M., Chen, H-J., Van den Bossche, J., van Roomen, C. P. P. A., Shami, A., Levels, J. H. M., Kroon, J., Lucas, T., Dimmeler, S., Lutgens, E. & de Winther, M. P. J., Aug 2018, In: Atherosclerosis. 275, p. 156-165 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access15 Citations (Scopus)