Projects per year
Personal profile
Research interests
The major focus of my research is HIV-1 pathogenesis, more specific the effect of dual HIV-1 infections. This research line started with the description of the first patient with a double HIV-1 superinfection, resulting in a triple infection with different virus subtypes: B-B'-AE (van der Kuyl et al, NEJM 2005 352: 2557-9). Longitudinal analysis of the patient's samples showed that all three strains remained present both in blood and seminal plasma for years, and that recombinant virus strains were formed.
Studies using RNA- or retroviruses have indicated that superinfections and especially co-infections lead to an increase in viral fitness. We speculated that HIV-1 co- or superinfection, contributes to the process of HIV-1 fitness gain and possibly to the higher virulence of the virus observed in contemporary cohorts in the western world.
Specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Projects
- 1 Active
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Berkhout B.: Virology
Berkhout, B., Cornelissen, M. T. E., van der Kuyl, A., van Hemert, F. J., Herrera Carrillo, E., van Montfort, T., Pasternak, A. O., van der Velden, Y. U., Vink, M. A., Zorgdrager, F. K., Brouwer, P. J. M., Gao, Z., van Haaren, M. M., Del Moral Sanchez, I., Overmars, R. J., Schorcht, A., Steba, G. S., de Taeye, S. W., Torrents de la Pena, A., Wang, G. & Klaver, B.
1/01/2006 → …
Project: Research
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Analysis of Simian Endogenous Retrovirus (SERV) Full-Length Proviruses in Old World Monkey Genomes
van der Kuyl, A. C., 1 Jan 2022, In: Genes. 13, 1, 119.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Contemporary distribution, estimated age, and prehistoric migrations of Old World monkey retroviruses
van der Kuyl, A. C., 3 Feb 2021, In: Epidemiologia. 2, 1, p. 46-67Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
The Dutch Cholera Epidemic of 1832 as seen through 19th Century Medical Publications
van der Kuyl, A., 3 Nov 2021, Utrecht: Eburon Academic Publishers. 244 p.Research output: Book/Report › Book › Professional
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Viruses in the reproductive tract: On their way to the germ line?
van der Kuyl, A. C. & Berkhout, B., 1 Sep 2020, In: Virus research. 286, 198101.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access2 Citations (Scopus) -
The evolution of subtype B HIV-1 tat in the Netherlands during 1985–2012
on behalf of the BEEHIVE Collaboration, 2018, In: Virus research. 250, p. 51-64Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus)
Press/Media
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De cholerapandemie van 1832: anders, maar ook hetzelfde
14/01/2022
1 item of Media coverage
Press/Media: Press / Media
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Net zoals met Covid hoopte Nederland dat het met cholera wel los zou lopen
18/12/2021
1 item of Media coverage
Press/Media: Press / Media
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‘Elke stad voerde zijn eigen gevecht met cholera’
18/12/2021
1 item of Media coverage
Press/Media: Press / Media