Projects per year
Personal profile
Research interests
I am specialized as a biomedical scientist and have extensive experience in metabolism, aging, and genetics in C. elegans. I was awarded an AMC PhD scholarship to pursue my PhD thesis, focusing on the metabolic control of aging in C. elegans, and earned my PhD degree in the fall of 2018 at the University of Amsterdam in the Netherlands. I continued my research on mitochondrial stress response and its role in metabolism and aging, under the supervision of prof. Johan Auwerx (EPFL, Switzerland) and supported by a post-doctoral fellowship (2019 Accelerator price winner). During the 3.5-year postdoc training, I initiated several projects focused on the role of lysosomes and their functions in stress responses and longevity. In the summer of 2022, I moved back to the Netherlands and am currently an Assistant Professor at the Amsterdam UMC - Location AMC. My research focuses on lysosomes, lipids, and aging, as well as translational projects that can benefit patients with lysosome disorders.
Collaborations and top research areas from the last five years
Projects
- 2 Active
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Houtkooper R.H.: [NO DATA]
Houtkooper, R., Denis, S., Bleeker, J., Chatzispyrou, I., Daniels, E., Gao, A., Held, N., Liu, J., Van Weeghel, M. & IJlst, L.
26/05/2015 → …
Project: Research
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Wanders R.J.A.: Focus of research
van de Beek, M., Chatzispyrou, I., Daniels, E., van Engen, C., Falkenberg, K., Gao, A., Held, N., Herzog, K., Khan, R., Schackmann, M., Liu, J., Wanders, R., Ferdinandusse, S., Kulik, W., van Roermund, C., Vaz, F., Houtkooper, R., te Brinke, H., Denis, S. & IJlst, L.
1/01/2007 → …
Project: Research
Research output
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Anti-retroviral treatment with zidovudine alters pyrimidine metabolism, reduces translation, and extends healthy longevity via ATF-4
McIntyre, R. L., Molenaars, M., Schomakers, B. V., Gao, A. W., Kamble, R., Jongejan, A., van Weeghel, M., van Kuilenburg, A. B. P., Possemato, R., Houtkooper, R. H. & Janssens, G. E., 31 Jan 2023, In: Cell reports. 42, 1, p. 1 20 p., 111928.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation
Li, T. Y., Wang, Q., Gao, A. W., Li, X., Sun, Y., Mottis, A., Shong, M. & Auwerx, J., Dec 2023, In: Cell discovery. 9, 1, 92.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Mass Spectrometry-Based Multi-omics Integration with a Single Set of C. elegans Samples
Zhu, Y., Jen, A., Overmyer, K. A., Gao, A. W., Shishkova, E., Auwerx, J. & Coon, J. J., 25 Jul 2023, In: Analytical Chemistry. 95, 29, p. 10930-10938 9 p.Research output: Contribution to journal › Article › Academic › peer-review
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V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans
Li, T. Y., Gao, A. W., Li, X., Li, H., Liu, Y. J., Lalou, A., Neelagandan, N., Naef, F., Schoonjans, K. & Auwerx, J., 2 Jan 2023, In: Journal of cell biology. 222, 1, e202205045.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains
Gao, A. W., el Alam, G., Lalou, A., Li, T. Y., Molenaars, M., Zhu, Y., Overmyer, K. A., Shishkova, E., Hof, K., Bou Sleiman, M., Houtkooper, R. H., Coon, J. J. & Auwerx, J., 18 Feb 2022, In: iScience. 25, 2, 103734.Research output: Contribution to journal › Article › Academic › peer-review
Open Access8 Citations (Scopus)
Prizes
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Award for outstanding poster and short talk presentation 2017 EMBO conference
Gao, Arwen (Recipient), 2017
Prize › Professional
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Nature Communications (Journal)
Arwen Gao (Reviewer)
2023Activity: Editorial work › Publication peer-review
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Dutch Translational Metabolism Conference 2023
Arwen Gao (Participant)
2022 → …Activity: Participating in or organising an event › Participation in conference › Academic
Press/Media
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Research Update from 2019 accelerators winner Arwen Gao, PhD
9/11/2023
1 Media contribution
Press/Media: Press / Media
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Deciphering Science's Secrets: Lifespan, UPR, and Lysosomal Pathways with Dr. Arwen Gao on The VitaDAO Aging Science Podcast
15/10/2023
1 Media contribution
Press/Media: Press / Media