1988 …2023

Research activity per year

Personal profile

Research interests

HIV replication and anti-viral strategies

This research line includes both basic and applied HIV research, which are intermingled and complement each other.

Basic research focuses on:
1. The structure and function of the HIV genome. In particular, we investigate the structure of the viral RNA and its role in different replication steps (such as transcription, RNA splicing, dimerization and packaging) and drug resistance.
2. The role of the viral Tat protein in HIV replication.

Applied research focuses on:
1. Novel strategies to inhibit HIV replication (based on the CRISPR/Cas9 system and RNA interference mechanism).
2. Development of conditionally replicating HIV variants as a novel approach toward a safe live-attenuated HIV vaccine and as a tool to study the host (immune) responses that correlate with protection induced by live-attenuated virus vaccines.
3. The use of viral evolution as a tool to develop new gene expression systems (Tet-On systems).


Molecular biology of human immunodeficiency virus (HIV)

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

External positions

Netherlands Commission on Genetic Modification (COGEM), Netherlands Commission on Genetic Modification (COGEM)

8 Jan 2018 → …

Collaborations and top research areas from the last five years

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