Projects per year
Personal profile
Research interests
The research focuses on understanding the biology of innate lymphoid cells which are important regulators and effectors of tissue immunity, homeostasis remodeling and repair. A second program is directed at optimising development of human immune system mice and a third to generate fully human monoclonal antibodies against tumor antigens
specialisation
Collaborations and top research areas from the last five years
Projects
- 1 Active
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Spits H.: The biology of human Innate Lymphoid Cells and B cells. Antibodies against tumor antigens
Bartels, L., Gillissen, M., de Jong, G., Krabbendam, L., van Lier, Y., Merat, S., Nagasawa, M., Spits, H., Bal, S., Bernink, J., Fergusson, J. R., Romero Ros, J., Golebski, K. & Shikhagaie, M. M.
1/01/2011 → …
Project: Research
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Inflammatory innate lymphoid cells predict response speed to dupilumab in chronic rhinosinusitis with nasal polyps
Golebski, K., van der Lans, R. J. L., van Egmond, D., de Groot, E., Spits, H., der Zee, A-H. M., van Drunen, C. M., Fokkens, W. J. & Reitsma, S., Dec 2023, In: Allergy: European Journal of Allergy and Clinical Immunology. 78, 12, p. 3265-3268 4 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open Access -
Reclassifying plasmacytoid dendritic cells as innate lymphocytes
Ziegler-Heitbrock, L., Ohteki, T., Ginhoux, F., Shortman, K. & Spits, H., Jan 2023, In: Nature Reviews. Immunology. 23, 1, p. 1-2 2 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
12 Citations (Scopus) -
Reply to ‘Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature’
Ziegler-Heitbrock, L., Ohteki, T., Ginhoux, F., Shortman, K. & Spits, H., May 2023, In: Nature reviews. Immunology. 23, 5, p. 338-339 2 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open Access3 Citations (Scopus) -
Altered Frequencies and Functions of Innate Lymphoid Cells in Melanoma Patients Are Modulated by Immune Checkpoints Inhibitors
Cristiani, C. M., Capone, M., Garofalo, C., Madonna, G., Mallardo, D., Tuffanelli, M., Vanella, V., Greco, M., Foti, D. P., Viglietto, G., Ascierto, P. A., Spits, H. & Carbone, E., 31 Jan 2022, In: Frontiers in immunology. 13, 811131.Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus) -
CD45RA+CD62L- ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs
Kokkinou, E., Pandey, R. V., Mazzurana, L., Gutierrez-Perez, I., Tibbitt, C. A., Weigel, W., Soini, T., Carrasco, A., Rao, A., Nagasawa, M., Bal, S. M., Jangard, M., Friberg, D., Lindforss, U., Nordenvall, C., Ljunggren, M., Haapaniemi, S., Keita, Å. V., Söderholm, J., Hedin, C., & 3 others , 15 Apr 2022, In: Science immunology. 7, 70, p. eabj8301 abj8301.Research output: Contribution to journal › Article › Academic › peer-review
8 Citations (Scopus)
Datasets
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Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1 at pH 5.5
McLellan, J. S. (Contributor), Chen, M. (Contributor), Joyce, M. G. (Contributor), Sastry, M. (Contributor), Stewart-Jones, G. B. E. (Contributor), Yang, Y. (Contributor), Zhang, B. (Contributor), Chen, L. (Contributor), Srivatsan, S. (Contributor), Zheng, A. (Contributor), Zhou, T. (Contributor), Graepel, K. W. (Contributor), Kumar, A. (Contributor), Moin, S. (Contributor), Boyington, J. C. (Contributor), Chuang, G. (Contributor), Soto, C. (Contributor), Baxa, U. (Contributor), Bakker, A. Q. (Contributor), Spits, H. (Contributor), Beaumont, T. (Contributor), Zheng, Z. (Contributor), Xia, N. (Contributor), Ko, S. (Contributor), Todd, J. (Contributor), Rao, S. (Contributor), Graham, B. S. (Contributor) & Kwong, P. D. (Contributor), Protein Data Bank (PDB), 20 Nov 2013
DOI: 10.2210/pdb4MMU, https://www.wwpdb.org/pdb?id=pdb_00004mmu
Dataset
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Altered Frequencies and Functions of Innate Lymphoid Cells in Melanoma Patients Are Modulated by Immune Checkpoints Inhibitors
Capone, M. (Contributor), Garofalo, C. (Contributor), Madonna, G. (Contributor), Mallardo, D. (Contributor), Tuffanelli, M. (Contributor), Vanella, V. (Contributor), Viglietto, G. (Contributor), Spits, H. (Contributor) & Carbone, E. (Contributor), ZENODO, 31 Jan 2022
DOI: 10.3389/fimmu.2022.811131, https://zenodo.org/record/6327295
Dataset
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Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 5.5
McLellan, J. S. (Contributor), Chen, M. (Contributor), Joyce, M. G. (Contributor), Sastry, M. (Contributor), Stewart-Jones, G. B. E. (Contributor), Yang, Y. (Contributor), Zhang, B. (Contributor), Chen, L. (Contributor), Srivatsan, S. (Contributor), Zheng, A. (Contributor), Zhou, T. (Contributor), Graepel, K. W. (Contributor), Kumar, A. (Contributor), Moin, S. (Contributor), Boyington, J. C. (Contributor), Chuang, G. (Contributor), Soto, C. (Contributor), Baxa, U. (Contributor), Bakker, A. Q. (Contributor), Spits, H. (Contributor), Beaumont, T. (Contributor), Zheng, Z. (Contributor), Xia, N. (Contributor), Ko, S. (Contributor), Todd, J. (Contributor), Rao, S. (Contributor), Graham, B. S. (Contributor) & Kwong, P. D. (Contributor), Protein Data Bank (PDB), 20 Nov 2013
DOI: 10.2210/pdb4MMS, https://www.wwpdb.org/pdb?id=pdb_00004mms
Dataset
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Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1-TriC at pH 9.5
McLellan, J. S. (Contributor), Chen, M. (Contributor), Joyce, M. G. (Contributor), Sastry, M. (Contributor), Stewart-Jones, G. B. E. (Contributor), Yang, Y. (Contributor), Zhang, B. (Contributor), Chen, L. (Contributor), Srivatsan, S. (Contributor), Zheng, A. (Contributor), Zhou, T. (Contributor), Graepel, K. W. (Contributor), Kumar, A. (Contributor), Moin, S. (Contributor), Boyington, J. C. (Contributor), Chuang, G. (Contributor), Soto, C. (Contributor), Baxa, U. (Contributor), Bakker, A. Q. (Contributor), Spits, H. (Contributor), Beaumont, T. (Contributor), Zheng, Z. (Contributor), Xia, N. (Contributor), Ko, S. (Contributor), Todd, J. (Contributor), Rao, S. (Contributor), Graham, B. S. (Contributor) & Kwong, P. D. (Contributor), Protein Data Bank (PDB), 20 Nov 2013
DOI: 10.2210/pdb4MMV, https://www.wwpdb.org/pdb?id=pdb_00004mmv
Dataset
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Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1 at pH 9.5
McLellan, J. S. (Contributor), Chen, M. (Contributor), Joyce, M. G. (Contributor), Sastry, M. (Contributor), Stewart-Jones, G. B. E. (Contributor), Yang, Y. (Contributor), Zhang, B. (Contributor), Chen, L. (Contributor), Srivatsan, S. (Contributor), Zheng, A. (Contributor), Zhou, T. (Contributor), Graepel, K. W. (Contributor), Kumar, A. (Contributor), Moin, S. (Contributor), Boyington, J. C. (Contributor), Chuang, G. (Contributor), Soto, C. (Contributor), Baxa, U. (Contributor), Bakker, A. Q. (Contributor), Spits, H. (Contributor), Beaumont, T. (Contributor), Zheng, Z. (Contributor), Xia, N. (Contributor), Ko, S. (Contributor), Todd, J. (Contributor), Rao, S. (Contributor), Graham, B. S. (Contributor) & Kwong, P. D. (Contributor), Protein Data Bank (PDB), 20 Nov 2013
DOI: 10.2210/pdb4MMT, https://www.wwpdb.org/pdb?id=pdb_00004mmt
Dataset