Babu Kurakula

Research output

Research output per year 2012 2015 2018 2019 2020 2021 2023

• 33 Article
• 7 Review article
• 1 Comment/Letter to the editor
• 1 Letter

Research output per year

Research output per year

Search results

• 2023

  Imaging the TGFβ type I receptor in pulmonary arterial hypertension

  Rotteveel, L., Poot, A. J., Kooijman, E. J. M., Schuit, R. C., Schalij, I., Sun, X., Kurakula, K., Happé, C., Beaino, W., ten Dijke, P., Lammertsma, A. A., Bogaard, H. J. & Windhorst, A. D., 2023, In: EJNMMI Research. 13, 1, 23.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2022

  Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling

  Kurakula, K., Hagdorn, Q. A. J., van der Feen, D. E., Vonk Noordegraaf, A., ten Dijke, P., de Boer, R. A., Bogaard, H. J., Goumans, M. J. & Berger, R. M. F., Feb 2022, In: Angiogenesis. 25, 1, p. 99-112 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  9 Citations (Scopus)

• Synthesis and preclinical evaluation of [¹¹C]LR111 and [¹⁸F]EW-7197 as PET tracers of the activin-receptor like kinase-5

  Rotteveel, L., Kurakula, K., Kooijman, E. J. M., Schuit, R. C., Verlaan, M., Schreurs, M., Beaino, W., van Dinther, M. A. H., ten Dijke, P., Lammertsma, A. A., Poot, A. J., Bogaard, H. J. & Windhorst, A. D., 1 Sept 2022, In: Nuclear medicine and biology. 112-113, p. 9-19 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)
• 2021

  Altered tgfβ/smad signaling in human and rat models of pulmonary hypertension: An old target needs attention

  Sanada, T. J., Sun, X. Q., Happé, C., Guignabert, C., Tu, L., Schalij, I., Bogaard, H. J., Goumans, M. J. & Kurakula, K., 6 Jan 2021, In: Cells. 10, 1, p. 1-13 13 p., 84.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  15 Citations (Scopus)

• Bmp receptor inhibition enhances tissue repair in endoglin heterozygous mice

  Bakker, W., Dingenouts, C. K. E., Lodder, K., Wiesmeijer, K. C., de Jong, A., Kurakula, K., Mager, H. J. J., Smits, A. M., de Vries, M. R., Quax, P. H. A. & Goumans, M. J. T. H., 2 Feb 2021, In: International journal of molecular sciences. 22, 4, p. 1-19 19 p., 2010.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension

  Tura-Ceide, O., Smolders, V. F. E. D., Aventin, N., Morén, C., Guitart-Mampel, M., Blanco, I., Piccari, L., Osorio, J., Rodríguez, C., Rigol, M., Solanes, N., Malandrino, A., Kurakula, K., Goumans, M. J., Quax, P. H. A., Peinado, V. I., Castellà, M. & Barberà, J. A., Dec 2021, In: Scientific reports. 11, 1, p. 18797 18797.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• Endothelial dysfunction in pulmonary hypertension: Cause or consequence?

  Kurakula, K., Smolders, V. F. E. D., Tura-Ceide, O., Wouter Jukema, J., Quax, P. H. A. & Goumans, M. J., 1 Jan 2021, In: Biomedicines. 9, 1, p. 1-23 23 p., 57.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  58 Citations (Scopus)

• Increased MAO-A activity promotes progression of pulmonary arterial hypertension

  Sun, X-Q., Peters, E. L., Schalij, I., Axelsen, J. B., Andersen, S., Kurakula, K., Gomez-Puerto, M. C., Szulcek, R., Pan, X., da Silva Goncalves Bos, D., Schiepers, R. E. J., Andersen, A., Goumans, M-J., Noordegraaf, A. V., van der Laarse, W. J., de Man, F. S. & Bogaard, H. J., 1 Mar 2021, In: American journal of respiratory cell and molecular biology. 64, 3, p. 331-343 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  13 Citations (Scopus)

• The inflammatory profile of cteph‐derived endothelial cells is a possible driver of disease progression

  Smolders, V. F. E. D., Lodder, K., Rodríguez, C., Tura‐ceide, O., Barberà, J. A., Wouter Jukema, J., Quax, P. H. A., Goumans, M. J. & Kurakula, K., Apr 2021, In: Cells. 10, 4, 737.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  15 Citations (Scopus)

• Volume Load-Induced Right Ventricular Failure in Rats Is Not Associated With Myocardial Fibrosis

  Hagdorn, Q. A. J., Kurakula, K., Koop, A. M. C., Bossers, G. P. L., Mavrogiannis, E., van Leusden, T., van der Feen, D. E., de Boer, R. A., Goumans, M. J. T. H. & Berger, R. M. F., 26 Feb 2021, In: Frontiers in physiology. 12, p. 557514 557514.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)
• 2020

  Cellular senescence impairs the reversibility of pulmonary arterial hypertension

  van der Feen, D. E., Bossers, G. P. L., Hagdorn, Q. A. J., Moonen, J. R., Kurakula, K., Szulcek, R., Chappell, J., Vallania, F., Donato, M., Kok, K., Kohli, J. S., Petersen, A. H., van Leusden, T., Demaria, M., Goumans, M. J. T. H., De Boer, R. A., Khatri, P., Rabinovitch, M., Berger, R. M. F. & Bartelds, B., 29 Jul 2020, In: Science Translational Medicine. 12, 554, eaaw4974.

  Research output: Contribution to journal › Article › Academic › peer-review
  60 Citations (Scopus)

• Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells

  Szulcek, R., Sanchez-Duffhues, G., Rol, N., Pan, X., Tsonaka, R., Dickhoff, C., Yung, L. M., Manz, X. D., Kurakula, K., Kiełbasa, S. M., Mei, H., Timens, W., Yu, P. B., Bogaard, H. J. & Goumans, M. J., 1 Nov 2020, In: ANGIOGENESIS. 23, 4, p. 699-714 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  21 Citations (Scopus)

• LIM-only protein FHL2 attenuates inflammation in vascular smooth muscle cells through inhibition of the NFκB pathway

  van de Pol, V., Vos, M., DeRuiter, M. C., Goumans, M. J., de Vries, C. J. M. & Kurakula, K., 1 Feb 2020, In: Vascular Pharmacology. 125-126, 106634.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)

• LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis

  INVENT Consortium, 1 Jun 2020, In: Haematologica. 105, 6, p. 1677-1685 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)

• The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient

  Happé, C., Kurakula, K., Sun, X. Q., da Silva Goncalves Bos, D., Rol, N., Guignabert, C., Tu, L., Schalij, I., Wiesmeijer, K. C., Tura-Ceide, O., Vonk Noordegraaf, A., de Man, F. S., Bogaard, H. J. & Goumans, M. J., 8 Jun 2020, In: Cells. 9, 6

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  21 Citations (Scopus)

• The effects of mercaptopurine on pulmonary vascular resistance and bmpr2 expression in pulmonary arterial hypertension

  Botros, L., Szulcek, R., Jansen, S. M. A., Kurakula, K., Goumans, M-J. T. H., van Kuilenburg, A. B. P., Noordegraaf, A. V., de Man, F. S., Aman, J. & Bogaard, H. J., 15 Jul 2020, In: American journal of respiratory and critical care medicine. 202, 2, p. 296-299 4 p.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic
  10 Citations (Scopus)
• 2019

  Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension

  Gomez-Puerto, M. C., van Zuijen, I., Huang, C. J. Z., Szulcek, R., Pan, X., van Dinther, M. A. H., Kurakula, K., Wiesmeijer, C. C., Goumans, M-J., Bogaard, H-J., Morrell, N. W., Rana, A. A. & ten Dijke, P., 1 Nov 2019, In: Journal of pathology. 249, 3, p. 356-367 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  26 Citations (Scopus)

• Effects of 6-mercaptopurine in pressure overload induced right heart failure

  Axelsen, J. B., Andersen, S., Sun, X-Q., Ringgaard, S., Hyldebrandt, J. A., Kurakula, K., Goumans, M-J., de Man, F. S., Nielsen-Kudsk, J. E., Bogaard, H-J. & Andersen, A., 2019, In: PLOS ONE. 14, 11, e0225122.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Scopus)

• Endothelial colony forming cells as an autologous model to study endothelial dysfunction in patients with a bicuspid aortic valve

  van de Pol, V., Bons, L. R., Lodder, K., Kurakula, K. B., Sanchez-Duffhues, G., Siebelink, H. M. J., Roos-Hesselink, J. W., Deruiter, M. C. & Goumans, M. J., 1 Jul 2019, In: International journal of molecular sciences. 20, 13, 3251.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)

• Multicenter preclinical validation of BET inhibition for the treatment of pulmonary arterial hypertension

  Van der Feen, D. E., Kurakula, K., Tremblay, E., Boucherat, O., Bossers, G. PL., Szulcek, R., Bourgeois, A., Lampron, M-C., Habbout, K., Martineau, S., Paulin, R., Kulikowski, E., Jahagirdar, R., Schalij, I., Bogaard, H. J., Bartelds, B., Provencher, S., Berger, R. M. F., Bonnet, S. & Goumans, M-J., 1 Oct 2019, In: American journal of respiratory and critical care medicine. 200, 7, p. 910-920 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  95 Citations (Scopus)

• Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

  Rol, N., De Raaf, M. A., Sun, X. Q., Kuiper, V. P., Da Silva Gonçalves Bos, D., Happé, C., Kurakula, K., Dickhoff, C., Thuillet, R., Tu, L., Guignabert, C., Schalij, I., Lodder, K., Pan, X., Herrmann, F. E., Van Nieuw Amerongen, G. P., Koolwijk, P., Vonk-Noordegraaf, A., De Man, F. S., Wollin, L., & 3 othersGoumans, M. J., Szulcek, R. & Bogaard, H. J., 1 Feb 2019, In: Cardiovascular research. 115, 2, p. 432-439 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  34 Citations (Scopus)

• Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling: Role of BMP signalling

  Kurakula, K., Sun, X-Q., Happé, C., da Silva Goncalves Bos, D., Szulcek, R., Schalij, I., Wiesmeijer, K. C., Lodder, K., Tu, L., Guignabert, C., de Vries, C. J. M., de Man, F. S., Vonk Noordegraaf, A., ten Dijke, P., Goumans, M-J. & Bogaard, H. J., 1 Sept 2019, In: European respiratory journal. 54, 3, 1802400.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  25 Citations (Scopus)

• Reply to piquereau and perros and to pullamsetti and de jesus perez

  Kurakula, K., Boucherat, O., Van Der Feen, DI. E., Bogaard, H. J., Kulikowski, E., Bartelds, B., Provencher, S., Berger, R. M. F., Bonnet, S. & Goumans, M. J., 1 Nov 2019, In: American journal of respiratory and critical care medicine. 200, 9, p. 1190-1191 2 p.

  Research output: Contribution to journal › Letter › Academic › peer-review

  Open Access
• 2018

  Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension

  Da Silva Gonçalves Bós, D., Van Der Bruggen, C. E. E., Kurakula, K., Sun, X. Q., Casali, K. R., Casali, A. G., Rol, N., Szulcek, R., Dos Remedios, C., Guignabert, C., Tu, L., Dorfmüller, P., Humbert, M., Wijnker, P. J. M., Kuster, D. W. D., Van Der Velden, J., Goumans, M. J., Bogaard, H. J., Vonk-Noordegraaf, A., De Man, F. S., & 1 othersHandoko, M. L., 1 Jan 2018, In: Circulation. 137, 9, p. 910-924 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  80 Citations (Scopus)

• Endothelial dysfunction in pulmonary arterial hypertension: loss of cilia length regulation upon cytokine stimulation

  Dummer, A., Rol, N., Szulcek, R., Kurakula, K., Pan, X., Visser, B. I., Bogaard, H. J., DeRuiter, M. C., Goumans, M-J. & Hierck, B. P., 27 Feb 2018, In: PULMONARY CIRCULATION. 8, 2, p. 2045894018764629

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  24 Citations (Scopus)

• Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of tissue factor gene expression, protein half-life, and pro-coagulant activity

  Kurakula, K., Koenis, D. S., Herzik, M. A., Liu, Y., Craft, J. W., van Loenen, P. B., Vos, M., Tran, M. K., Versteeg, H. H., Goumans, M. J. T. H., Ruf, W., de Vries, C. J. M. & Şen, M., 3 Jun 2018, In: Haematologica. 103, 6, p. 1073-1082 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  13 Citations (Scopus)

• TGF-β and BMPR2 Signaling in PAH: Two Black Sheep in One Family

  Rol, N., Kurakula, K. B., Happé, C., Bogaard, H. J. & Goumans, M. J., 31 Aug 2018, In: International journal of molecular sciences. 19, 9, 2585.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  70 Citations (Scopus)
• 2017

  Thoracic aortic aneurysm development in patients with bicuspid aortic valve: What is the role of endothelial cells?

  van de Pol, V., Kurakula, K., DeRuiter, M. C. & Goumans, M. J., 30 Nov 2017, In: Frontiers in physiology. 8, NOV, 938.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  29 Citations (Scopus)
• 2016

  Protein-protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease

  Tran, M. K., Kurakula, K., Koenis, D. S. & de Vries, C. J. M., 1 Feb 2016, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 2, p. 219-228 10 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  53 Citations (Scopus)
• 2015

  6-Mercaptopurine reduces cytokine and Muc5ac expression involving inhibition of NFκB activation in airway epithelial cells

  Kurakula, K., Hamers, A. A., van Loenen, P. & de Vries, C. J. M., 19 Jun 2015, In: Respiratory research. 16, 1, p. 73 73.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  27 Citations (Scopus)

• Cardiac endothelial cells express Wilms' tumor-1. Wt1 expression in the developing, adult and infarcted heart.

  Duim, S. N., Kurakula, K., Goumans, M. J. & Kruithof, B. P. T., 1 Apr 2015, In: Journal of molecular and cellular cardiology. 81, p. 127-135 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  76 Citations (Scopus)

• Deficiency of FHL2 attenuates airway inflammation in mice and genetic variation associates with human bronchial hyper-responsiveness

  Kurakula, K., Vos, M., Logiantara, A., Roelofs, J. J. T. H., Nieuwenhuis, M. A., Koppelman, G. H., Postma, D. S., Brandsma, C. A., Sin, D. D., Bossé, Y., Nickle, D. C., Van Rijt, L. S. & De Vries, C. J. M., 1 Dec 2015, In: Allergy: European Journal of Allergy and Clinical Immunology. 70, 12, p. 1531-1544 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  13 Citations (Scopus)

• LIM-only protein FHL2 is a positive regulator of liver X receptors in smooth muscle cells involved in lipid homeostasis

  Kurakula, K., Sommer, D., Sokolovic, M., Moerland, P. D., Scheij, S., van Loenen, P. B., Koenis, D. S., Zelcer, N., van Tiel, C. M. & de Vries, C. J. M., 2015, In: Molecular and Cellular Biology. 35, 1, p. 52-62 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• LIM-only protein FHL2 regulates experimental pulmonary Schistosoma mansoni egg granuloma formation

  Kurakula, K., Vos, M., van Eijk, M., Smits, H. H. & de Vries, C. J. M., 1 Nov 2015, In: European journal of immunology. 45, 11, p. 3098-3106 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  9 Citations (Scopus)

• Nuclear receptor Nur77 attenuates airway inflammation in mice by suppressing NF-κB activity in lung epithelial cells

  Kurakula, K., Vos, M., Logiantara, A., Roelofs, J. J., Nieuwenhuis, M. A., Koppelman, G. H., Postma, D. S., Van Rijt, L. S. & De Vries, C. J. M., 15 Aug 2015, In: Journal of Immunology. 195, 4, p. 1388-1398 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  56 Citations (Scopus)

• Regulatory rnas controlling vascular (DYS)function by affecting TGF-β family signalling

  Kurakula, K., Goumans, M. J. & Dijke, P. T., 10 Jul 2015, In: EXCLI Journal. 14, p. 832-850 19 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  11 Citations (Scopus)
• 2014

  Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: New target for an old drug

  Marinković, G., Kroon, J., Hoogenboezem, M., Hoeben, K. A., Ruiter, M. S., Kurakula, K., Rubio, I. O., Vos, M., De Vries, C. J. M., Van Buul, J. D. & De Waard, V., 1 May 2014, In: Journal of Immunology. 192, 9, p. 4370-4378 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  43 Citations (Scopus)

• NR4A nuclear receptors are orphans but not lonesome

  Kurakula, K., Koenis, D. S., van Tiel, C. M. & de Vries, C. J. M., Nov 2014, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 11, p. 2543-2555 13 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access
  108 Citations (Scopus)

• The LIM-only protein FHL2 reduces vascular lesion formation involving inhibition of proliferation and migration of smooth muscle cells

  Kurakula, K., Vos, M., Rubio, I. O., Marinković, G., Buettner, R., Heukamp, L. C., Stap, J., De Waard, V., Van Tiel, C. M. & De Vries, C. J. M., 15 Apr 2014, In: PLOS ONE. 9, 4, p. e94931-(9 p.) e94931.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  17 Citations (Scopus)
• 2013

  Nuclear Receptors in atherosclerosis: A superfamily with many 'Goodfellas'

  Kurakula, K., Hamers, A. A. J., De Waard, V. & De Vries, C. J. M., 10 Apr 2013, In: Molecular and cellular endocrinology. 368, 1-2, p. 71-84 14 p.

  Research output: Contribution to journal › Review article › Academic › peer-review
  15 Citations (Scopus)
• 2012

  Bone marrow-specific deficiency of nuclear receptor Nur77 enhances atherosclerosis

  Hamers, A. A. J., Vos, M., Rassam, F., Marincovic, G., Kurakula, K., Van Gorp, P. J., De Winther, M. P. J., Gijbels, M. J. J., De Waard, V. & De Vries, C. J. M., 3 Feb 2012, In: Circulation Research. 110, 3, p. 428-438 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  152 Citations (Scopus)

• Dual function of Pin1 in NR4A nuclear receptor activation: Enhanced activity of NR4As and increased Nur77 protein stability

  van Tiel, C. M., Kurakula, K., Koenis, D. S., van der Wal, E. & de Vries, C. J. M., Oct 2012, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1823, 10, p. 1894-1904 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  24 Citations (Scopus)