Projects per year
Personal profile
Research interests
My research group strives at understanding cardiac physiology and pathology by combining a wide range of research of approaches including molecular and electrophysiological techniques.
The experiments we perform center around three main research goals:
1. Establishing the molecular and electrophysiological basis of outflow tract arrhythmias.
2.Unraveling the arrhythmogenic mechanisms underlying J-wave syndromes.
3. Development of autonomic nervous system targets for anti-arrhythmic therapy.
4.Characterizing the evolutionary adaptations in cardiac electrophysiology.
Collaborations
Understanding cardiovascular disease requires interdisciplinary research. The combination of genetics, molecular biology and electrophysiology is a powerful method for unravelling disease mechanisms. I often take part in synergic collaborations in the AMC (PMIDs: 32386467, 31666509) and at national (PMID: 32555305, 30681347) and international level (PMIDs: 31695764, 32290757, 27582060).
specialisation
Developmental, molecular and clinical aspects of life-threatening arrhythmias.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Associate Professor, Maastricht University: CARIM
1 Feb 2022 → 1 Feb 2030
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Finished
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Atrial Fibrillation detection in Lmna mutant mice by an innovative ex vivo precision approach: dissection role of bio-electrical impairment
1/01/2023 → 1/01/2024
Project: Research
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Knock-in swine model reveals new arrhythmia mechanism in Timothy syndrome
Boukens, B. J., Verkerk, A. O. & Bezzina, C. R., Jan 2024, In: Nature cardiovascular research. 3, 1, p. 18-20 3 p.Research output: Contribution to journal › Article › Academic › peer-review
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A comprehensive framework for evaluation of high pacing frequency and arrhythmic optical mapping signals
Ramlugun, G. S., Kulkarni, K., Pallares-Lupon, N., Boukens, B. J., Efimov, I. R., Vigmond, E. J., Bernus, O. & Walton, R. D., 23 Jan 2023, In: Frontiers in physiology. 14, 734356.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility
Bosada, F. M., van Duijvenboden, K., Giovou, A. E., Rivaud, M. R., Uhm, J-S., Verkerk, A. O., Boukens, B. J. & Christoffels, V. M., 1 Jan 2023, In: eLife. 12, e80317.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus) -
Cardiac Repolarization in Health and Disease
Krijger, C., Amin, A. S., Offerhaus, J. A., Bezzina, C. R. & Boukens, B. J., 1 Jan 2023, In: JACC: Clinical Electrophysiology. 9, 1, p. 124-138 15 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access2 Citations (Scopus) -
Delayed Activation Due to Early Repolarization: A Combination of Hypotheses
Boukens, B. J. & Coronel, R., 1 Aug 2023, In: JACC: Clinical Electrophysiology. 9, 8, p. 1262-1264 3 p.Research output: Contribution to journal › Editorial › Academic › peer-review
2 Citations (Scopus)
Datasets
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Additional file 9 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
Pei, J. (Contributor), Harakalova, M. (Creator), Treibel, T. A. (Creator), Lumbers, R. T. (Contributor), Boukens, B. (Creator), Efimov, I. R. (Creator), Van Dinter, J. T. (Contributor), González, A. (Creator), López, B. (Creator), El Azzouzi, H. (Contributor), Van Den Dungen, N. (Contributor), Van Dijk, C. G. M. (Contributor), Krebber, M. M. (Creator), Den Ruijter, H. M. (Contributor), Pasterkamp, G. (Creator), Duncker, D. J. (Creator), Nieuwenhuis, E. E. S. (Creator), De Weger, R. (Contributor), Huibers, M. M. (Creator), Vink, A. (Creator), Moore, J. H. (Creator), Moon, J. C. (Creator), Verhaar, M. C. (Creator), Kararigas, G. (Creator), Mokry, M. (Creator), Asselbergs, F. W. (Creator), Cheng, C. (Creator), Treibel, T. A. (Creator), López, B. (Creator) & Asselbergs, F. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12655624.v1, https://springernature.figshare.com/articles/Additional_file_9_of_H3K27ac_acetylome_signatures_reveal_the_epigenomic_reorganization_in_remodeled_non-failing_human_hearts/12655624/1
Dataset
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Additional file 9 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
Pei, J. (Contributor), Harakalova, M. (Creator), Treibel, T. A. (Creator), Lumbers, R. T. (Contributor), Boukens, B. (Creator), Efimov, I. R. (Creator), Van Dinter, J. T. (Contributor), González, A. (Creator), López, B. (Creator), El Azzouzi, H. (Contributor), Van Den Dungen, N. (Contributor), Van Dijk, C. G. M. (Contributor), Krebber, M. M. (Creator), Den Ruijter, H. M. (Contributor), Pasterkamp, G. (Creator), Duncker, D. J. (Creator), Nieuwenhuis, E. E. S. (Creator), De Weger, R. (Contributor), Huibers, M. M. (Creator), Vink, A. (Creator), Moore, J. H. (Creator), Moon, J. C. (Creator), Verhaar, M. C. (Creator), Kararigas, G. (Creator), Mokry, M. (Creator), Asselbergs, F. W. (Creator), Cheng, C. (Creator), Treibel, T. A. (Creator), López, B. (Creator) & Asselbergs, F. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12655624, https://springernature.figshare.com/articles/Additional_file_9_of_H3K27ac_acetylome_signatures_reveal_the_epigenomic_reorganization_in_remodeled_non-failing_human_hearts/12655624
Dataset
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Additional file 7 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
Pei, J. (Contributor), Harakalova, M. (Creator), Treibel, T. A. (Creator), Lumbers, R. T. (Contributor), Boukens, B. (Creator), Efimov, I. R. (Creator), Van Dinter, J. T. (Contributor), González, A. (Creator), López, B. (Creator), El Azzouzi, H. (Contributor), Van Den Dungen, N. (Contributor), Van Dijk, C. G. M. (Contributor), Krebber, M. M. (Creator), Den Ruijter, H. M. (Contributor), Pasterkamp, G. (Creator), Duncker, D. J. (Creator), Nieuwenhuis, E. E. S. (Creator), De Weger, R. (Contributor), Huibers, M. M. (Creator), Vink, A. (Creator), Moore, J. H. (Creator), Moon, J. C. (Creator), Verhaar, M. C. (Creator), Kararigas, G. (Creator), Mokry, M. (Creator), Asselbergs, F. W. (Creator), Cheng, C. (Creator), Treibel, T. A. (Creator), López, B. (Creator) & Asselbergs, F. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12655618.v1, https://springernature.figshare.com/articles/Additional_file_7_of_H3K27ac_acetylome_signatures_reveal_the_epigenomic_reorganization_in_remodeled_non-failing_human_hearts/12655618/1
Dataset
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Additional file 11 of H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts
Pei, J. (Contributor), Harakalova, M. (Creator), Treibel, T. A. (Creator), Lumbers, R. T. (Contributor), Boukens, B. (Creator), Efimov, I. R. (Creator), Van Dinter, J. T. (Contributor), González, A. (Creator), López, B. (Creator), El Azzouzi, H. (Contributor), Van Den Dungen, N. (Contributor), Van Dijk, C. G. M. (Contributor), Krebber, M. M. (Creator), Den Ruijter, H. M. (Contributor), Pasterkamp, G. (Creator), Duncker, D. J. (Creator), Nieuwenhuis, E. E. S. (Creator), De Weger, R. (Contributor), Huibers, M. M. (Creator), Vink, A. (Creator), Moore, J. H. (Creator), Moon, J. C. (Creator), Verhaar, M. C. (Creator), Kararigas, G. (Creator), Mokry, M. (Creator), Asselbergs, F. W. (Creator), Cheng, C. (Creator), Treibel, T. A. (Creator), López, B. (Creator) & Asselbergs, F. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12655588.v1, https://springernature.figshare.com/articles/Additional_file_11_of_H3K27ac_acetylome_signatures_reveal_the_epigenomic_reorganization_in_remodeled_non-failing_human_hearts/12655588/1
Dataset
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Additional file 12 of Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations
Pei, J. (Contributor), Schuldt, M. (Contributor), Nagyova, E. (Contributor), Gu, Z. (Contributor), el Bouhaddani, B. S. (Contributor), Yiangou, L. (Contributor), Jansen, M. (Contributor), Calis, J. J. A. (Contributor), Dorsch, L. M. (Contributor), Blok, C. S. (Contributor), van den Dungen, D. D. N. A. M. (Contributor), Lansu, N. (Contributor), Boukens, B. (Contributor), Efimov, I. R. (Contributor), Michels, M. (Contributor), Verhaar, M. C. (Contributor), de Weger, W. R. (Contributor), Vink, A. (Contributor), van Steenbeek, S. F. G. (Contributor), Baas, A. F. (Contributor), Davis, R. P. (Contributor), Uh, H. W. (Contributor), Kuster, D. W. D. (Contributor), Cheng, C. (Contributor), Mokry, M. (Contributor), van der Velden, D. V. J. (Contributor), Asselbergs, F. W. (Contributor) & Harakalova, M. (Creator), Figshare, 2021
DOI: 10.6084/m9.figshare.14302785, https://springernature.figshare.com/articles/dataset/Additional_file_12_of_Multi-omics_integration_identifies_key_upstream_regulators_of_pathomechanisms_in_hypertrophic_cardiomyopathy_due_to_truncating_MYBPC3_mutations/14302785
Dataset