Brenda Penninx

Research activity per year

If you made any changes in Pure these will be visible here soon.

Research interests

Brenda Penninx, PhD, is professor of psychiatric epidemiology at the department of Psychiatry of Amsterdam UMC (location VUmc) in Amsterdam (https://psychiatryamsterdam.nl). She serves as vice-Department Chair and member of the Management Team. Since 2004 she leads the multi-site Netherlands Study of Depression and Anxiety (NESDA: www.nesda.nl), a longitudinal study of the course and consequences of depressive and anxiety disorders.

Penninx received >50 M Euro from various national and international (EU or NIH) research grants, including the prestigious personal VIDI and VICI grants. Her current research group (10 assistant professors/ postdocs and >20 PhD students) is truly multidisciplinary: persons with diverse backgrounds (psychiatry, psychology, neuroscience, epidemiology, mathematics, data science, sociology) together examine the etiology, treatment and consequences of depressive and anxiety disorders. More than 55 students have already obtained their PhD-degree under her supervision. Penninx has published over 1000 international articles, which are well cited (>70,000 citations, H-index>125). In 2016, Brenda Penninx has been elected as member of the Royal Dutch Academy of Sciences and Arts (KNAW).

In addition to her leading the NESDA project, she has been involved in several other Dutch and international cohort and intervention studies over the last 20 years. Central themes in her research are understanding psychosocial, environmental, somatic, genetic and neurobiological risk factors and consequences of depression and anxiety disorders and how to intervene on these to improve mental health. Penninx participates e.g. in the EU-funded MoodFood, Lifebrain, PRISM. RADAR-CNS. Earlycause, To_Aition and Respond projects.

The intergenerational transmission of stress and resilience is studied in the longitudinal multi-site MARIO project. The treatment response antidepressants and the efficacy of antidepressant discontinuation, is the theme of another multi-site, longitudinal cohort and RCT project onder her leadership: OPERA project.

Finally, to better understand the impact of daily-life stress, Penninx recently established the Stress-in-Action (SiA) Consortium. Its goal is to enable synergistic collaborations to discover how daily-life stress can be reliably measured, how it determines health, how individual variation impacts on daily-life stress, and how to intervene in a personalized manner on daily-life stress. Brenda Penninx is the Coordinator of this Consortium.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

External positions

Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School OfMedicine, Winston-Salem, NC, United States

2000 → 2003

4 Active

inflaMED: Precision psychiatry: Anti-inflammatory medication in Immuno-metabolic depression
Lamers, F., Milaneschi, Y., Penninx, B., Vinkers, C. & Zwiep, J.
1/09/2021 → 31/08/2025
Project: Research
RESET: REStoring mood in Early life Trauma
Linsen, F., Gathier, A., Broeder, C., Sep, M., Verhoeven, J., Schoonheim, M., van Oppen, P., Penninx, B. & Vinkers, C.
1/01/2020 → …
Project: Research
PERCIM: Personalized Care for Depression: Bringing Immuno-Metabolic Depression from Bench to Bedside
Lamers, F., Jansen, R., Vreijling, S., Penninx, B., Beekman, A., Bot, M., Milaneschi, Y., Bremmer, M. & Rhebergen, D.
1/10/2019 → 30/09/2023
Project: Research
OPERA: Netherlands study of Optimal, Personal Antidepressant use
Penninx, B., Bot, M., Maarsingh, O., Vinkers, C. & Bet, P.
1/01/2019 → 31/12/2023
Project: Research

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity
the EarlyCause Consortium, 30 Jun 2023, In: PLOS Genetics. 19, 6, e1010508.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders
Verhoeven, J. E., Han, L. K. M., Lever-van Milligen, B. A., Hu, M. X., Révész, D. R., Hoogendoorn, A. W., Batelaan, N. M., van Schaik, D. J. F., van Balkom, A. J. L. M., van Oppen, P. & Penninx, B. W. J. H., 15 May 2023, In: Journal of affective disorders. 329, p. 19-29 11 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access

3 Citations (Scopus)
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder
Amare, A. T., Thalamuthu, A., Schubert, K. O., Fullerton, J. M., Ahmed, M., Hartmann, S., Papiol, S., Heilbronner, U., Degenhardt, F., Tekola-Ayele, F., Hou, L., Hsu, Y-H., Shekhtman, T., Adli, M., Akula, N., Akiyama, K., Ardau, R., Arias, B. R., Aubry, J-M., Hasler, R., & 146 othersRichard-Lepouriel, H. L., Perroud, N., Backlund, L., Bhattacharjee, A. K., Bellivier, F., Benabarre, A., Bengesser, S., Biernacka, J. M., Birner, A., Marie-Claire, C., Cervantes, P., Chen, H-C., Chillotti, C., Cichon, S., Cruceanu, C., Czerski, P. M., Dalkner, N., del Zompo, M., DePaulo, J. R., Étain, B., Jamain, S., Falkai, P., Forstner, A. J., Frisen, L., Frye, M. A., Gard, S. B., Garnham, J. S., Goes, F. S., Grigoroiu-Serbanescu, M., Fallgatter, A. J., Stegmaier, S., Ethofer, T., Biere, S., Petrova, K., Schuster, C., Adorjan, K., Budde, M., Heilbronner, M., Kalman, J. L., Kohshour, M. O., Reich-Erkelenz, D., Schaupp, S. K., Schulte, E. C., Senner, F., Vogl, T., Anghelescu, I-G., Arolt, V., Dannlowski, U., Dietrich, D., Figge, C., Jäger, M., Lang, F. U., Juckel, G., Konrad, C., Reimer, J., Schmauß, M., Schmitt, A., Spitzer, C., von Hagen, M., Wiltfang, J., Zimmermann, J. R., Andlauer, T. F. M., Fischer, A., Bermpohl, F., Ritter, P., Matura, S., Gryaznova, A., Falkenberg, I., Yildiz, C. N., Kircher, T., Schmidt, J., Koch, M., Gade, K., Trost, S., Haussleiter, I. S., Lambert, M., Rohenkohl, A. C., Kraft, V., Grof, P., Hashimoto, R., Hauser, J., Herms, S., Hoffmann, P., Jiménez, E., Kahn, J-P., Kassem, L., Kuo, P-H., Kato, T., Kelsoe, J., Kittel-Schneider, S., Ferensztajn-Rochowiak, E., König, B., Kusumi, I., Laje, G., Landén, M., Lavebratt, C., Leboyer, M., Leckband, S. G., Tortorella, A., Manchia, M., Martinsson, L., McCarthy, M. J., McElroy, S., Colom, F., Millischer, V., Mitjans, M., Mondimore, F. M., Monteleone, P., Nievergelt, C. M., Nöthen, M. M., Novák, T., O’Donovan, C., Ozaki, N., Pfennig, A., Pisanu, C., Potash, J. B., Reif, A., Reininghaus, E., Rouleau, G. A., Rybakowski, J. K., Schalling, M., Schofield, P. R., Schweizer, B. W., Severino, G., Shilling, P. D., Shimoda, K., Simhandl, C., Slaney, C. M., Squassina, A., Stamm, T., Stopkova, P., Maj, M., Turecki, G., Vieta, E., Veeh, J., Witt, S. H., Wright, A., Zandi, P. P., Mitchell, P. B., Bauer, M., Alda, M., Rietschel, M., McMahon, F. J., Schulze, T. G., Clark, S. R. & Baune, B. T., 2023, (E-pub ahead of print) In: Molecular psychiatry.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
Challenges in Using mHealth Data From Smartphones and Wearable Devices to Predict Depression Symptom Severity: Retrospective Analysis
RADAR-CNS Consortium, 14 Aug 2023, In: Journal of medical Internet research. 25, p. e45233 e45233.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
Childhood trauma and anger in adults with and without depressive and anxiety disorders
de Bles, N. J., Pütz, L. E. H., Rius Ottenheim, N., van Hemert, A. M., Elzinga, B. M., Penninx, B. W. J. H. & Giltay, E. J., Sept 2023, In: Acta psychiatrica Scandinavica. 148, 3, p. 288-301 14 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Netherlands Study of Derpession and Anxiety
Penninx, B. (Creator), NESDA consortium: www.nesda.nl, 2021
Dataset

Award for "Highly cited author”
Penninx, Brenda (Recipient), 2014
Prize: Other distinction
Epidemioloog B (registered senior epidemiologist) by the Netherlands Society of Epidemiology
Penninx, Brenda (Recipient), 1988
Prize: Other distinction
Fellow, Gerontological Society of America
Penninx, Brenda (Recipient), 2006
Prize: Other distinction
Fellowship, Brookdale Foundation Leadership on Aging award
Penninx, Brenda (Recipient), 2000
Prize: Other distinction
Member of the Royal Dutch Academy of Sciences and Arts (KNAW)
Penninx, Brenda (Recipient), 2016
Prize: Other distinction

49 Invited talk
18 Membership of committee
13 Membership of board
3 Lecture / Presentation
More

Immunometabolic pathways for precision medicine strategies in depression.
Brenda Penninx (Speaker)
27 Nov 2020
Activity: Talk or presentation › Invited talk › Academic
Research on the biology of Depression across the lifespan: Big questions and opportunities.
Brenda Penninx (Speaker)
6 Oct 2020
Activity: Talk or presentation › Invited talk › Academic
Royal Dutch Academy of Arts and Sciences (KNAW) (External organisation)
Brenda Penninx (Chair)
1 Jan 2020 → …
Activity: Membership › Membership of committee › Academic
Immunometabolic depression: relevant for clinical practice?
Brenda Penninx (Speaker)
17 Jun 2020
Activity: Talk or presentation › Oral presentation › Academic
Personalized medicine in depression: a realistic way forward?
Brenda Penninx (Speaker)
28 Nov 2020
Activity: Talk or presentation › Invited talk › Academic

GZ psychologie: Je kunt beter aan een kind zelf vragen hoe het gaat
Brenda Penninx
1/11/2021
1 Media contribution
Press/Media: Interview
Aanpak depressies: ‘Veel mensen vallen na zes jaar toch weer terug’
Brenda Penninx
3/10/2020
1 Media contribution
Press/Media: Interview
Brenda Penninx: puzzling over depression
Brenda Penninx
10/07/2017
1 item of Media coverage
Press/Media: Interview
Amersfoortse hoogleraar bestrijdt volksziekte nr. 1: depressie
BWJH Penninx
31/07/2016
1 Media contribution
Press/Media: Interview

Brenda Penninx

Personal profile

Research interests

Expertise related to UN Sustainable Development Goals

External positions

Collaborations and top research areas from the last five years

Dive into details

inflaMED: Precision psychiatry: Anti-inflammatory medication in Immuno-metabolic depression

RESET: REStoring mood in Early life Trauma

PERCIM: Personalized Care for Depression: Bringing Immuno-Metabolic Depression from Bench to Bedside

OPERA: Netherlands study of Optimal, Personal Antidepressant use

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity

Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders

Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

Challenges in Using mHealth Data From Smartphones and Wearable Devices to Predict Depression Symptom Severity: Retrospective Analysis

Childhood trauma and anger in adults with and without depressive and anxiety disorders

Netherlands Study of Derpession and Anxiety

Award for "Highly cited author”

Epidemioloog B (registered senior epidemiologist) by the Netherlands Society of Epidemiology

Fellow, Gerontological Society of America

Fellowship, Brookdale Foundation Leadership on Aging award

Member of the Royal Dutch Academy of Sciences and Arts (KNAW)

Immunometabolic pathways for precision medicine strategies in depression.

Research on the biology of Depression across the lifespan: Big questions and opportunities.

Royal Dutch Academy of Arts and Sciences (KNAW) (External organisation)

Immunometabolic depression: relevant for clinical practice?

Personalized medicine in depression: a realistic way forward?

GZ psychologie: Je kunt beter aan een kind zelf vragen hoe het gaat

Aanpak depressies: ‘Veel mensen vallen na zes jaar toch weer terug’

Brenda Penninx: puzzling over depression

Amersfoortse hoogleraar bestrijdt volksziekte nr. 1: depressie

Brenda Penninx

Personal profile

Research interests

Expertise related to UN Sustainable Development Goals

External positions

Collaborations and top research areas from the last five years

Projects

Research output

Datasets

Prizes

Activities

Press/Media