Projects per year
Personal profile
Research interests
Brenda Penninx, PhD, is professor of psychiatric epidemiology at the department of Psychiatry of Amsterdam UMC (location VUmc) in Amsterdam (https://psychiatryamsterdam.nl). She serves as vice-Department Chair and member of the Management Team. Since 2004 she leads the multi-site Netherlands Study of Depression and Anxiety (NESDA: www.nesda.nl), a longitudinal study of the course and consequences of depressive and anxiety disorders.
Penninx received >50 M Euro from various national and international (EU or NIH) research grants, including the prestigious personal VIDI and VICI grants. Her current research group (10 assistant professors/ postdocs and >20 PhD students) is truly multidisciplinary: persons with diverse backgrounds (psychiatry, psychology, neuroscience, epidemiology, mathematics, data science, sociology) together examine the etiology, treatment and consequences of depressive and anxiety disorders. More than 55 students have already obtained their PhD-degree under her supervision. Penninx has published over 1000 international articles, which are well cited (>70,000 citations, H-index>125). In 2016, Brenda Penninx has been elected as member of the Royal Dutch Academy of Sciences and Arts (KNAW).
In addition to her leading the NESDA project, she has been involved in several other Dutch and international cohort and intervention studies over the last 20 years. Central themes in her research are understanding psychosocial, environmental, somatic, genetic and neurobiological risk factors and consequences of depression and anxiety disorders and how to intervene on these to improve mental health. Penninx participates e.g. in the EU-funded MoodFood, Lifebrain, PRISM. RADAR-CNS. Earlycause, To_Aition and Respond projects.
The intergenerational transmission of stress and resilience is studied in the longitudinal multi-site MARIO project. The treatment response antidepressants and the efficacy of antidepressant discontinuation, is the theme of another multi-site, longitudinal cohort and RCT project onder her leadership: OPERA project.
Finally, to better understand the impact of daily-life stress, Penninx recently established the Stress-in-Action (SiA) Consortium. Its goal is to enable synergistic collaborations to discover how daily-life stress can be reliably measured, how it determines health, how individual variation impacts on daily-life stress, and how to intervene in a personalized manner on daily-life stress. Brenda Penninx is the Coordinator of this Consortium.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School OfMedicine, Winston-Salem, NC, United States
2000 → 2003
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 5 Active
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SiA: Stress in Action: Advancing the Science of Stress by Moving the Lab to Daily Life
de Geus, J., Penninx, B. & Bartels, M.
1/01/2023 → 1/01/2033
Project: Research
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inflaMED: Precision psychiatry: Anti-inflammatory medication in Immuno-metabolic depression
Lamers, F., Milaneschi, Y., Penninx, B., Vinkers, C. & Zwiep, J.
1/09/2021 → 31/08/2025
Project: Research
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RESET: REStoring mood in Early life Trauma
Linsen, F., Gathier, A., Broeder, C., Sep, M., Verhoeven, J., Schoonheim, M., van Oppen, P., Penninx, B. & Vinkers, C.
1/01/2020 → …
Project: Research
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PERCIM: Personalized Care for Depression: Bringing Immuno-Metabolic Depression from Bench to Bedside
Lamers, F., Jansen, R., Vreijling, S., Penninx, B., Beekman, A., Bot, M., Milaneschi, Y., Bremmer, M. & Rhebergen, D.
1/10/2019 → 30/09/2023
Project: Research
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OPERA: Netherlands study of Optimal, Personal Antidepressant use
Penninx, B., Bot, M., Maarsingh, O., Vinkers, C. & Bet, P.
1/01/2019 → 31/12/2023
Project: Research
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Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders
Verhoeven, J. E., Han, L. K. M., Lever-van Milligen, B. A., Hu, M. X., Révész, D. R., Hoogendoorn, A. W., Batelaan, N. M., van Schaik, D. J. F., van Balkom, A. J. L. M., van Oppen, P. & Penninx, B. W. J. H., 15 May 2023, In: Journal of affective disorders. 329, p. 19-29 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Deep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort
Jensen, K. H. J. R., Dam, V. H., Ganz, M., Fisher, P. M., Ip, C-T., Sankar, A., Marstrand-Joergensen, M. R., Ozenne, B., Osler, M., Penninx, B. W. J. H., Pinborg, L. H., Frokjaer, V. G., Knudsen, G. M. & Jørgensen, M. B., 1 Dec 2023, In: BMC Psychiatry. 23, 1, 151.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants
on behalf of the EarlyCause consortium, 1 Dec 2023, In: BMC medicine. 21, 1, 93.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Design and rationale of the REStoring mood after early life trauma with psychotherapy (RESET-psychotherapy) study: a multicenter randomized controlled trial on the efficacy of adjunctive trauma-focused therapy (TFT) versus treatment as usual (TAU) for adult patients with major depressive disorder (MDD) and childhood trauma
Gathier, A. W., Verhoeven, J. E., van Oppen, P. C., Penninx, B. W. J. H., Merkx, M. J. M., Dingemanse, P., Stehouwer, K. M. K. S., van den Bulck, C. M. M. & Vinkers, C. H., 1 Dec 2023, In: BMC Psychiatry. 23, 1, 41.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Efficacy of celecoxib add-on treatment for immuno-metabolic depression: Protocol of the INFLAMED double-blind placebo-controlled randomized controlled trial
Zwiep, J. C., Bet, P. M., Rhebergen, D., Nurmohamed, M. T., Vinkers, C. H., Penninx, B. W. J. H., Milaneschi, Y. & Lamers, F., Feb 2023, In: Brain, behavior, & immunity - health. 27, p. 100585 100585.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Datasets
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Netherlands Study of Derpession and Anxiety
Penninx, B. (Creator), NESDA consortium: www.nesda.nl, 2021
Dataset
Prizes
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Epidemioloog B (registered senior epidemiologist) by the Netherlands Society of Epidemiology
Penninx, Brenda (Recipient), 1988
Prize: Other distinction
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Fellowship, Brookdale Foundation Leadership on Aging award
Penninx, Brenda (Recipient), 2000
Prize: Other distinction
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Member of the Royal Dutch Academy of Sciences and Arts (KNAW)
Penninx, Brenda (Recipient), 2016
Prize: Other distinction
Activities
- 3 Lecture / Presentation
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Depressive symptoms, chronic pain, and falls in older adults. The MOBILIZE Boston Study
L.H.P. Eggermont (Speaker), B.W.J.H. Penninx (Speaker), R.N. Jones (Speaker) & S.G. Leveille (Speaker)
18 Nov 2011Activity: Talk or presentation › Lecture / Presentation › Academic
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Genome-wide association study of co-morbid anxiety in major depression
C.M. Middeldorp (Speaker), N.R. Wray (Speaker), P.F. Sullivan (Speaker), J.J. Hottenga (Speaker), G. Willemsen (Speaker), E.J.C. de Geus (Speaker), R. van Dyck (Speaker), W.A. Nolen (Speaker), F.G. Zitman (Speaker), D.I. Boomsma (Speaker) & B.W.J.H. Penninx (Speaker)
11 Oct 2008Activity: Talk or presentation › Lecture / Presentation › Academic
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Physical ability vs physical self-efficacy as predictors of mortality?
D.J.H. Deeg (Speaker), R.J. Bosscher (Speaker) & B.W.J.H. Penninx (Speaker)
18 Nov 1998Activity: Talk or presentation › Lecture / Presentation › Academic
Press/Media
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GZ psychologie: Je kunt beter aan een kind zelf vragen hoe het gaat
1/11/2021
1 Media contribution
Press/Media: Interview
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Aanpak depressies: ‘Veel mensen vallen na zes jaar toch weer terug’
3/10/2020
1 Media contribution
Press/Media: Interview
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Amersfoortse hoogleraar bestrijdt volksziekte nr. 1: depressie
31/07/2016
1 Media contribution
Press/Media: Interview