Canan Alhan

Research output

Research output per year 2009 2009 2011 2012 2013 2016 2017 2021 2023 2024

• 30 Article
• 1 Chapter
• 1 Conference contribution
• 1 Poster
• 3 More
  • 1 Meeting Abstract
  • 1 Review article
  • 1 Phd-Thesis - Research and graduation internal

Research output per year

Research output per year

Search results

• 2024

  Determinants of lenalidomide response with or without erythropoiesis-stimulating agents in myelodysplastic syndromes: the HOVON89 trial

  van de Loosdrecht, A. A., Cremers, E. M. P., Alhan, C., Duetz, C., in ’t Hout, F. E. M., Visser-Wisselaar, H. A., Chitu, D. A., Verbrugge, A., Cunha, S. M., Ossenkoppele, G. J., Janssen, J. J. W. M., Klein, S. K., Vellenga, E., Huls, G. A., Muus, P., Langemeijer, S. M. C., de Greef, G. E., te Boekhorst, P. A. W., Raaijmakers, M. H. G., van Marwijk Kooy, M., & 20 othersLegdeur, M. C., Wegman, J. J., Deenik, W., de Weerdt, O., van Maanen-Lamme, T. M., Jobse, P., van Kampen, R. J. W., Beeker, A., Wijermans, P. W., Biemond, B. J., Tanis, B. C., van Esser, J. W. J., Schaar, C. G., Noordzij-Nooteboom, H. S., Jacobs, E. M. G., de Graaf, A. O., Jongen-Lavrencic, M., Stevens-Kroef, M. J. P. L., Westers, T. M. & Jansen, J. H., Apr 2024, In: Leukemia. 38, 4, p. 840-850 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)
• 2023

  Clinical application of flow cytometry in patients with unexplained cytopenia and suspected myelodysplastic syndrome: A report of the European LeukemiaNet International MDS-Flow Cytometry Working Group

  van de Loosdrecht, A. A., Kern, W., Porwit, A., Valent, P., Kordasti, S., Cremers, E., Alhan, C., Duetz, C., Dunlop, A., Hobo, W., Preijers, F., Wagner-Ballon, O., Chapuis, N., Fontenay, M., Bettelheim, P., Eidenschink-Brodersen, L., Font, P., Johansson, U., Loken, M. R., te Marvelde, J. G., & 15 othersMatarraz, S., Ogata, K., Oelschlaegel, U., Orfao, A., Psarra, K., Subirá, D., Wells, D. A., Béné, M. C., Della Porta, M. G., Burbury, K., Bellos, F., van der Velden, V. H. J., Westers, T. M., Saft, L. & Ireland, R., 15 Jan 2023, In: Cytometry Part B - Clinical Cytometry. 104, 1, p. 77-86 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  18 Citations (Scopus)

• Flow cytometric analysis of myelodysplasia: Pre-analytical and technical issues—Recommendations from the European LeukemiaNet

  van der Velden, V. H. J., Preijers, F., Johansson, U., Westers, T. M., Dunlop, A., Porwit, A., Béné, M. C., Valent, P., te Marvelde, J., Wagner-Ballon, O., Oelschlaegel, U., Saft, L., Kordasti, S., Ireland, R., Cremers, E., Alhan, C., Duetz, C., Hobo, W., Chapuis, N., Fontenay, M., & 16 othersBettelheim, P., Eidenshink-Brodersen, L., Font, P., Loken, M. R., Matarraz, S., Ogata, K., Orfao, A., Psarra, K., Subirá, D., Wells, D. A., Della Porta, M. G., Burbury, K., Bellos, F., Weiß, E., Kern, W. & van de Loosdrecht, A., 15 Jan 2023, In: Cytometry Part B - Clinical Cytometry. 104, 1, p. 15-26

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  16 Citations (Scopus)
• 2021

  Distinct bone marrow immunophenotypic features define the splicing factor 3B subunit 1 (SF3B1)-mutant myelodysplastic syndromes subtype

  Duetz, C., Westers, T. M., in ’t Hout, F. E. M., Cremers, E. M. P., Alhan, C., Venniker-Punt, B., Visser-Wisselaar, H. A., Chitu, D. A., de Graaf, A. O., Smit, L., Jansen, J. H. & van de Loosdrecht, A. A., May 2021, In: British journal of haematology. 193, 4, p. 798-803 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  6 Citations (Scopus)

• Dysplasia and PNH-type cells in bone marrow aspirates of myelodysplastic syndromes

  Westers, T. M., Alhan, C., Visser-Wisselaar, H. A., Chitu, D. A. & van de Loosdrecht, A. A., 2021, (E-pub ahead of print) In: Cytometry Part B - Clinical Cytometry.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Monitoring treatment with 5-Azacitidine by flow cytometry predicts duration of hematological response in patients with myelodysplastic syndrome

  Subirá, D., Alhan, C., Oelschlaegel, U., Porwit, A., Psarra, K., Westers, T. M., Golbano, N., Nilsson, L., van de Loosdrecht, A. A. & de Miguel, D., Jul 2021, In: Annals of Hematology. 100, 7, p. 1711-1722 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  4 Citations (Scopus)
• 2017

  Genomic array as compared to karyotyping in myelodysplastic syndromes in a prospective clinical trial

  Stevens-Kroef, M. J., Olde Weghuis, D., ElIdrissi-Zaynoun, N., van der Reijden, B., Cremers, E. M. P., Alhan, C., Westers, T. M., Visser-Wisselaar, H. A., Chitu, D. A., Cunha, S. M., Vellenga, E., Klein, S. K., Wijermans, P., de Greef, G. E., Schaafsma, M. R., Muus, P., Ossenkoppele, G. J., van de Loosdrecht, A. A. & Jansen, J. H., 1 Jul 2017, In: Genes Chromosomes and Cancer. 56, 7, p. 524-534 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  15 Citations (Scopus)

• Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes

  HOVON89 study group, 2017, In: Haematologica. 102, 2, p. 320-326 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  55 Citations (Scopus)
• 2016

  Application of Flow Cytometry for Myelodysplastic Syndromes: Pitfalls and Technical Considerations

  Alhan, C., Westers, T. M., Cremers, E. M. P., Cali, C., Ossenkoppele, G. J. & van de Loosdrecht, A. A., Jul 2016, In: Cytometry Part B. Clinical Cytometry. 90, 4, p. 358-367

  Research output: Contribution to journal › Article › Academic › peer-review
  19 Citations (Scopus)

• Good’s syndrome: An uncommon cause of therapy-resistant diarrhoea

  Disselhorst, M. J., Dickhoff, C. & Alhan, C., 1 Aug 2016, In: Netherlands journal of medicine. 74, 7, p. 309-312 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  5 Citations (Scopus)

• Multiparameter flow cytometry is instrumental to distinguish myelodysplastic syndromes from non-neoplastic cytopenias

  Cremers, E. M. P., Westers, T. M., Alhan, C., Cali, C., Wondergem, M. J., Poddighe, J., Ossenkoppele, G. J. & van de Loosdrecht, A. A., Feb 2016, In: European Journal of Cancer. 54, p. 49-56

  Research output: Contribution to journal › Article › Academic › peer-review
  36 Citations (Scopus)

• The myelodysplastic syndromes flow cytometric score: a three-parameter prognostic flow cytometric scoring system

  Alhan, C., Westers, T. M., Cremers, E. M. P., Cali, C., Witte, B. I., Ossenkoppele, G. J. & van de Loosdrecht, A. A., Mar 2016, In: Leukemia. 30, 3, p. 658-665

  Research output: Contribution to journal › Article › Academic › peer-review
  42 Citations (Scopus)
• 2015

  Successful Combination of Sequential Gene Therapy and Rescue Allo-HSCT in Two Children with X-CGD - Importance of Timing

  Siler, U., Paruzynski, A., Holtgreve-Grez, H., Kuzmenko, E., Koehl, U., Renner, E. D., Alhan, C., van de Loosdrecht, A. A., Schwable, J., Pfluger, T., Tchinda, J., Schmugge, M., Jauch, A., Naundorf, S., Kuhlcke, K., Notheis, G., Gungor, T., von Kalle, C., Schmidt, M., Grez, M., & 2 othersSeger, R. & Reichenbach, J., 2015, In: Current Gene Therapy. 15, 4, p. 416-427

  Research output: Contribution to journal › Article › Academic › peer-review
  50 Citations (Scopus)
• 2014

  Absence of aberrant myeloid progenitors by flow cytometry is associated with favorable response to azacitidine in higher risk myelodysplastic syndromes

  Alhan, C., Westers, T. M., van der Helm, L. H., Eeltink, C. M., Huls, G., Witte, B. I., Buchi, F., Santini, V., Ossenkoppele, G. J. & van de Loosdrecht, A. A., 2014, In: Cytometry Part B. Clinical Cytometry. 86, 3, p. 207-215

  Research output: Contribution to journal › Article › Academic › peer-review
  35 Citations (Scopus)

• High flow cytometric scores identify adverse prognostic subgroups within the revised international prognostic scoring system for myelodysplastic syndromes

  Alhan, C., Westers, T. M., Cremers, E. M. P., Cali, C., Witte, B. I., Ossenkoppele, G. J. & van de Loosdrecht, A. A., 2014, In: British journal of haematology. 167, 1, p. 100-109

  Research output: Contribution to journal › Article › Academic › peer-review
  29 Citations (Scopus)
• 2013

  Azacitidine results in comparable outcome in newly diagnosed AML patients with more or less than 30% bone marrow blasts

  van der Helm, L. H., Veeger, N. J. G. M., van Marwijk Kooy, M., Beeker, A., de Weerdt, O., de Groot, M., Alhan, C., Hoogendoorn, M., Laterveer, L., van de Loosdrecht, A. A., Koedam, J., Vellenga, E. & Huls, G., 2013, In: Leukemia research. 37, 8, p. 877-882

  Research output: Contribution to journal › Article › Academic › peer-review
  32 Citations (Scopus)

• Rationale for the clinical application of flow cytometry in patients with myelodysplastic syndromes: position paper of an International Consortium and the European LeukemiaNet Working Group

  van de Loosdrecht, A. A., Ireland, R., Kern, W., la Porta, M. G., Alhan, C., Balleisen, J. S., Bettelheim, P., Bowen, D. T., Burbury, K., Eidenschink, L., Cazzola, M., Chu, S. S. C., Cullen, M., Cutler, J. A., Drager, A. M., Feuillard, J., Fenaux, P., Font, P., Germing, U., Haase, D., & 31 othersHellstrom-Lindberg, E., Johansson, U., Kordasti, S., Loken, M. R., Malcovati, L., te Marvelde, J. G., Matarraz, S., Milne, T., Moshaver, B., Mufti, G. J., Nikolova, V., Ogata, K., Oelschlaegel, U., Orfao, A., Ossenkoppele, G. J., Porwit, A., Platzbecker, U., Preijers, F., Psarra, K., Richards, S. J., Subira, D., Seymour, J. F., Tindell, V., Vallespi, T., Valent, P., van der Velden, V. H. J., Wells, D. A., de Witte, T. M., Zettl, F., Bene, M. C. & Westers, T. M., 2013, In: Leukemia and Lymphoma. 54, 3, p. 472-475

  Research output: Contribution to journal › Article › Academic › peer-review
  61 Citations (Scopus)

• Treatment with lenalidomide in myelodysplastic syndromes with deletion 5q: results from the Dutch named patient program

  Abouyahya, I., Alhan, C., Westers, T. M., te Boekhorst, P. A., Kappers-Klunne, MC., Coenen, J. L., Heyning, F. H., Huls, G. A., de Wolf, JT., Imholz, A. L., Koene, H. R., Veth, G., de Kruijf, E. J. F. M., Muus, P., Planken, E. V., Segeren, C. M., Vasmel, W. L., van der Velden, A. M., Velders, G. A., Koedam, J., & 2 othersOssenkoppele, G. J. & van de Loosdrecht, A. A., 2013, In: Leukemia and Lymphoma. 54, 4, p. 874-877

  Research output: Contribution to journal › Article › Academic › peer-review
  1 Citation (Scopus)
• 2012

  Azacitidine differentially affects CD4(pos) T-cell polarization in vitro and in vivo in high risk myelodysplastic syndromes

  Bontkes, H. J., Ruben, J. M., Alhan, C., Westers, T. M., Ossenkoppele, G. J. & van de Loosdrecht, A. A., 2012, In: Leukemia research. 36, 7, p. 921-930

  Research output: Contribution to journal › Article › Academic › peer-review
  33 Citations (Scopus)

• Implementation of flow cytometry in the diagnostic work-up of myelodysplastic syndromes in a multicenter approach: Report from the Dutch Working Party on Flow Cytometry in MDS

  Westers, T. M., van der Velden, V. H. J., Alhan, C., Bekkema, R., Bijkerk, A., Brooimans, R. A., Cali, C., Dräger, A. M., de Haas, V., Homburg, C., de Jong, A., Kuiper-Kramer, P. A., Leenders, M., Lommerse, I., Marvelde, J. G. T., van der Molen-Sinke, J., Moshaver, B., Mulder, A. B., Preijers, F. W. M. B., Schindhelm, R. K., & 4 othersSluijs, A., van Wering, E. R., Westra, A. H. & van de Loosdrecht, A. A., 2012, In: Leukemia research. 36, 4, p. 422-430

  Research output: Contribution to journal › Article › Academic › peer-review
  31 Citations (Scopus)

• Multicenter validation of a reproducible flow cytometric score for the diagnosis of low-grade myelodysplastic syndromes: results of a European LeukemiaNET study

  la Porta, M. G., Picone, C., Pascutto, C., Malcovati, L., Tamura, H., Handa, H., Czader, M., Freeman, S., Vyas, P., Porwit, A., Saft, L., Westers, T. M., Alhan, C., Cali, C., van de Loosdrecht, A. A. & Ogata, K., 2012, In: Haematologica. 97, 8, p. 1209-1217

  Research output: Contribution to journal › Article › Academic › peer-review
  136 Citations (Scopus)

• Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group

  Westers, T. M., Ireland, R., Kern, W., Alhan, C., Balleisen, J. S., Bettelheim, P., Burbury, K., Cullen, M., Cutler, J. A., la Porta, M. G., Dräger, A. M., Feuillard, J., Font, P., Germing, U., Haase, D., Johansson, U., Kordasti, S., Loken, M. R., Malcovati, L., te Marvelde, J. G., & 19 othersMatarraz, S., Milne, T., Moshaver, B., Mufti, G. J., Ogata, K., Orfao, A., Porwit, A., Psarra, K., Richards, S. J., Subira, D., Tindell, V., Vallespi, T., Valent, P., van der Velden, V. H. J., de Witte, T. M., Wells, D. A., Zettl, F., Bene, M. C. & van de Loosdrecht, A. A., 2012, In: Leukemia. 26, 7, p. 1730-1741

  Research output: Contribution to journal › Article › Academic › peer-review
  221 Citations (Scopus)
• 2011

  Platelet doubling after the first azacitidine cycle is a promising predictor for response in myelodysplastic syndromes (MDS), chronic myelomonocytic leukaemia (CMML) and acute myeloid leukaemia (AML) patients in the Dutch azacitidine compassionate named patient programme

  van der Helm, L. H., Alhan, C., Wijermans, P. W., van Marwijk Kooy, M., Schaafsma, R., Biemond, B. J., Beeker, A., Hoogendoorn, M., van Rees, B. P., de Weerdt, O., Wegman, J., Libourel, W. J., Luykx-de Bakker, S. A., Minnema, M. C., Brouwer, R. E., Croon-de Boer, F., Eefting, M., Jie, K-S. G., van de Loosdrecht, A. A., Koedam, J., & 4 othersVeeger, N. J. G. M., Vellenga, E., Huls, G. & Luykx-de Bakker, SA., 2011, In: British journal of haematology. 155, 5, p. 599-606

  Research output: Contribution to journal › Article › Academic › peer-review
  101 Citations (Scopus)

• Role of immune responses in the pathogenesis of low-risk MDS and high-risk MDS: implications for immunotherapy

  Agarwal, S., van de Loosdrecht, A. A., Alhan, C., Ossenkoppele, G. J., Westers, T. M. & Bontkes, H. J., 2011, In: British journal of haematology. 153, 5, p. 568-581

  Research output: Contribution to journal › Article › Academic › peer-review
  83 Citations (Scopus)
• 2010

  Aberrant immunophenotype of blasts in myelodysplastic syndromes is a clinically relevant biomarker in predicting response to growth factor treatment

  Westers, T. M., Alhan, C., Chamuleau, M. E. D., van der Vorst, M. J. D. L., Eeltink, C. M., Ossenkoppele, G. J. & van de Loosdrecht, A. A., 2010, In: Blood. 115, 9, p. 1779-1784

  Research output: Contribution to journal › Article › Academic › peer-review
  80 Citations (Scopus)
• 2009

  De rol van flowcytometrie in de classificatie van het myelodysplastisch syndroom

  Alhan, C., Westers, T. M., Ossenkoppele, G. J. & van de Loosdrecht, A. A., 2009, In: Nederlands Tijdschrift voor Hematologie. 6, 2, p. 40-48

  Research output: Contribution to journal › Article › Professional

• De rol van flowcytometrie in de classificatie van het myelodysplastisch syndroom

  Alhan, C., Westers, T. M., Ossenkoppele, G. J. & van de Loosdrecht, A. A., 2009, In: Tijdschrift van de Belgische vereniging van laboratoriumtechnologen. 36, p. 421-432

  Research output: Contribution to journal › Article › Professional

• Do peripheral blasts count in myelodysplastic syndromes?

  Alhan, C., Westers, T. M., Ossenkoppele, G. J. & van de Loosdrecht, A. A., 2009, In: Leukemia research. 33, 2, p. 209-211

  Research output: Contribution to journal › Article › Academic › peer-review
  4 Citations (Scopus)

• P043 Aberrant immunophenotype of blasts in low and intermediate-1 risk myelodysplastic syndromes predicts response to growth factor treatment. A prospective clinical phase II study

  Westers, T., Alhan, C., van der Vorst, M., Chamuleau, M., Eeltink, C., Ossenkoppele, G. & van de Loosdrecht, A., 2009, In: Leukemia research. 33, SUPPL. 1

  Research output: Contribution to journal › Article › Academic › peer-review

• Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndromes

  van de Loosdrecht, A. A., Alhan, C., Bene, M. C., Porta, M., Drager, A. M., Feuillard, J., Font, P., Germing, U., Haase, D., Homburg, C. H., Ireland, R., Jansen, J. L., Kern, W., Malcovati, L., Marvelde, J. G. T., Mufti, G. J., Ogata, K., Orfao, A., Ossenkoppele, G. J., Porwit, A., & 12 othersPreijers, F. W. M. B., Richards, S. J., Schuurhuis, G. J., Subira, D., Valent, P., van der Velden, V., Vyas, P., Westra, A. H., de Witte, T. M., Wells, D. E., Loken, M. R. & Westers, T. M., 2009, In: Haematologica. 94, 8, p. 1124-1134

  Research output: Contribution to journal › Article › Academic › peer-review
  210 Citations (Scopus)