Projects per year
Personal profile
Research interests
• Translational studies into cardiac sodium channel (dys)function and inherited sodium channelopathies (including SCN5A mutations) associated with cardiac arrhythmias and sudden cardiac death, incorporating clinical and genetic with functional and mechanistic studies in transgenic models and human induced pluripotent stem cell-derived (iPSC) cardiomyocytes.
• Basic studies aimed at (1) unraveling mechanisms by which defective sodium channels mediate cardiac conduction slowing and arrhythmogenesis, (2) the complexity of sodium channel function and regulation, and (3) their diverse (non-electrogenic) roles in cardiac structure and function.
• Identification of novel (genetic) determinants, modifiers and pathways mediating cardiac electrophysiology and arrhythmia risk.
• Translational studies aimed at identifying novel targets for the prevention and treatment of cardiac arrhythmias and sudden cardiac death.
specialisation
Basic and translational cardiac electrophysiology
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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Remme C.A.: [NO DATA]
Marchal, G., Podliesna, S., Rivaud, M., Remme, C., Casini, S., Portero, V., Marchal, G. & Wolswinkel, R.
29/04/2014 → …
Project: Research
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Coxsackie and Adenovirus Receptor Is a Modifier of Cardiac Conduction and Arrhythmia Vulnerability in the Setting of Myocardial Ischemia
Marsman, R. F. J., Bezzina, C. R., Freiberg, F., Verkerk, A. O., Adriaens, M. E., Podliesna, S., Chen, C., Purfürst, B., Spallek, B., Koopmann, T. T., Baczko, I., dos Remedios, C. G., George, A. L., Bishopric, N. H., Lodder, E. M., de Bakker, J. M. T., Fischer, R., Coronel, R., Wilde, A. A. M., Gotthardt, M., & 1 others, 2014, In: Journal of the American College of Cardiology. 63, 6, p. 549-559Research output: Contribution to journal › Article › Academic › peer-review
50 Citations (Scopus) -
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Bezzina, C. R., Barc, J., Mizusawa, Y., Remme, C. A., Gourraud, J-B., Simonet, F., Verkerk, A. O., Schwartz, P. J., Crotti, L., Dagradi, F., Guicheney, P., Fressart, V., Leenhardt, A., Antzelevitch, C., Bartkowiak, S., Borggrefe, M., Schimpf, R., Schulze-Bahr, E., Zumhagen, S., Behr, E. R., & 45 others, 2013, In: Nature Genetics. 45, 9, p. 1044-1049Research output: Contribution to journal › Article › Academic › peer-review
425 Citations (Scopus) -
Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes
Portero, V., Casini, S., Hoekstra, M., Verkerk, A. O., Mengarelli, I., Belardinelli, L., Rajamani, S., Wilde, A. A. M., Bezzina, C. R., Veldkamp, M. W. & Remme, C. A., 2017, In: Cardiovascular research. 113, 7, p. 829-838Research output: Contribution to journal › Article › Academic › peer-review
36 Citations (Scopus) -
Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes
Rivaud, M. R., Agullo-Pascual, E., Lin, X., Leo-Macias, A., Zhang, M., Rothenberg, E., Bezzina, C. R., Delmar, M. & Remme, C. A., 2017, In: Journal of the American Heart Association. 6, 12, p. e007622Research output: Contribution to journal › Article › Academic › peer-review
26 Citations (Scopus) -
Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium-glucose cotransporter 2 inhibitors
Wijnker, P. J. M., Dinani, R., van der Laan, N. C., Algül, S., Knollmann, B. C., Verkerk, A. O., Remme, C. A., Zuurbier, C. J., Kuster, D. W. D. & van der Velden, J., 1 Feb 2024, In: Cardiovascular research. 120, 3, p. 301-317 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus)