Projects per year
Personal profile
Research interests
• Translational studies into cardiac sodium channel (dys)function and inherited sodium channelopathies (including SCN5A mutations) associated with cardiac arrhythmias and sudden cardiac death, incorporating clinical and genetic with functional and mechanistic studies in transgenic models and human induced pluripotent stem cell-derived (iPSC) cardiomyocytes.
• Basic studies aimed at (1) unraveling mechanisms by which defective sodium channels mediate cardiac conduction slowing and arrhythmogenesis, (2) the complexity of sodium channel function and regulation, and (3) their diverse (non-electrogenic) roles in cardiac structure and function.
• Identification of novel (genetic) determinants, modifiers and pathways mediating cardiac electrophysiology and arrhythmia risk.
• Translational studies aimed at identifying novel targets for the prevention and treatment of cardiac arrhythmias and sudden cardiac death.
Specialisation
Basic and translational cardiac electrophysiology
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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Remme C.A.: [NO DATA]
Marchal, G. A., Podliesna, S., Rivaud, M., Remme, C., Casini, S., Portero, V. M., Marchal, G. A. & Wolswinkel, R.
29/04/2014 → …
Project: Research
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Coxsackie and Adenovirus Receptor Is a Modifier of Cardiac Conduction and Arrhythmia Vulnerability in the Setting of Myocardial Ischemia
Marsman, R. F. J., Bezzina, C. R., Freiberg, F., Verkerk, A. O., Adriaens, M. E., Podliesna, S., Chen, C., Purfürst, B., Spallek, B., Koopmann, T. T., Baczko, I., dos Remedios, C. G., George, A. L., Bishopric, N. H., Lodder, E. M., de Bakker, J. M. T., Fischer, R., Coronel, R., Wilde, A. A. M., Gotthardt, M., & 1 others, 2014, In: Journal of the American College of Cardiology. 63, 6, p. 549-559Research output: Contribution to journal › Article › Academic › peer-review
43 Citations (Scopus) -
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Bezzina, C. R., Barc, J., Mizusawa, Y., Remme, C. A., Gourraud, J-B., Simonet, F., Verkerk, A. O., Schwartz, P. J., Crotti, L., Dagradi, F., Guicheney, P., Fressart, V., Leenhardt, A., Antzelevitch, C., Bartkowiak, S., Borggrefe, M., Schimpf, R., Schulze-Bahr, E., Zumhagen, S., Behr, E. R., & 45 others, 2013, In: Nature Genetics. 45, 9, p. 1044-1049Research output: Contribution to journal › Article › Academic › peer-review
373 Citations (Scopus) -
Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes
Portero, V., Casini, S., Hoekstra, M., Verkerk, A. O., Mengarelli, I., Belardinelli, L., Rajamani, S., Wilde, A. A. M., Bezzina, C. R., Veldkamp, M. W. & Remme, C. A., 2017, In: Cardiovascular Research. 113, 7, p. 829-838Research output: Contribution to Journal › Article › Academic › peer-review
29 Citations (Scopus) -
Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes
Rivaud, M. R., Agullo-Pascual, E., Lin, X., Leo-Macias, A., Zhang, M., Rothenberg, E., Bezzina, C. R., Delmar, M. & Remme, C. A., 2017, In: Journal of the American Heart Association. 6, 12, p. e007622Research output: Contribution to Journal › Article › Academic › peer-review
22 Citations (Scopus) -
2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death
ESC Scientific Document Group, 21 Oct 2022, In: European heart journal. 43, 40, p. 3997-4126 130 p.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access28 Citations (Scopus)