Projects per year
Personal profile
Research interests
We study the gut-liver axis in the pathogenesis of liver diseases, including NAFLD/NASH (MAFLD/MASH) and cholestasis. We aim to identify gut-derived factors and intestinal/hepatic signaling pathways involved in the pathogenesis of aforementioned diseases.
specialisation
Lipid and glucose Metabolism, transport processes in the liver, cholestasis, NAFLD, NASH
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, The molecular basis of conjugated hyperbilirubinemia, Amsterdam UMC
1 Apr 1994 → 1 Oct 1998
Award Date: 1 Oct 1998
Keywords
- Q Science (General)
- Lipid metabolism
- energy metabolism
- hepatic transport
- cholestasis
- NAFLD
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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van de Graaf K.F.J. (Stan): metabolite dynamics and liver-centered organ crosstalk
van de Graaf, S., Appelman, M., Chen, H., Donkers, J., Hubers, L., van Niekerk, J., Roscam Abbing, R., Slijepcevic, D., van de Wiel, S., Oude Elferink, R., de Waart, R., Paulusma, C., Duijst, S., Beuers, U., Bolt, I., Vogels, E., In het Panhuis, W., Kunst, R., Wu, D., Trampert, D. C., Kersten, R., Groenen, C. & Nguyen, T.
1/06/2016 → …
Project: Research
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Oude Elferink R.P.J.: Hepatic transport processes and Bioartificial Liver Support
Abdelrahman Abubakr Adam, A., Appelman, M., Bolier, A., Chang, J., Chen, H., van Dijk, R., Donkers, J., Folmer, D., Hohenester, S., Langedijk, J., van der Mark, V., Naik, J., van Niekerk, J., Roscam Abbing, R., Shi, X., Slijepcevic, D., van de Wiel, S., Oude Elferink, R., van de Graaf, S., Paulusma, C., de Waart, R., Hoekstra, R., Chamuleau, R., Duijst, S., Ho - Mok, K. S., Terlouw - Tolenaars, D. & de Jonge, H.
1/01/2006 → 1/03/2023
Project: Research
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Bile salt signaling and bile salt-based therapies in cardiometabolic disease
Groenen, C. C. J., Nguyen, T-A., Paulusma, C. C. & van de Graaf, S. F. J., 10 Jan 2024, In: Clinical science (London, England : 1979). 138, 1, p. 1-21 21 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access1 Citation (Scopus) -
Amino acid metabolism, transport and signalling in the liver revisited
Paulusma, C. C., Lamers, W. H., Broer, S. & van de Graaf, S. F. J., 1 Jul 2022, In: Biochemical Pharmacology. 201, 115074.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access35 Citations (Scopus) -
ATP8B1 Deficiency Results in Elevated Mitochondrial Phosphatidylethanolamine Levels and Increased Mitochondrial Oxidative Phosphorylation in Human Hepatoma Cells
Gómez-Mellado, V. E., Chang, J-C., Ho-Mok, K. S., Bernardino Morcillo, C., Kersten, R. H. J., Oude Elferink, R. P. J., Verhoeven, A. J. & Paulusma, C. C., 15 Oct 2022, In: International journal of molecular sciences. 23, 20, 12344.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
CDC50A is required for aminophospholipid transport and cell fusion in mouse C2C12 myoblasts
Grifell-Junyent, M., Baum, J. F., Valimets, S., Herrmann, A., Paulusma, C. C., Lopez-Marques, R. L. & Pomorski, T. G., 1 Mar 2022, In: Journal of Cell Science. 135, 5, jcs258649.Research output: Contribution to journal › Article › Academic › peer-review
Open Access9 Citations (Scopus) -
Role of the IgG4-related cholangitis autoantigen annexin A11 in cholangiocyte protection
Herta, T., Kersten, R., Chang, J-C., Hubers, L., Go, S., Tolenaars, D., Paulusma, C. C., Nathanson, M. H., Elferink, R. O., van de Graaf, S. F. J. & Beuers, U., 1 Feb 2022, In: Journal of Hepatology. 76, 2, p. 319-331 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access10 Citations (Scopus)