Projects per year
Most of my research since my PhD in 2008 has focused on hepatitis C virus (HCV), which has resulted in a current productive research line, encompassing several aspects of HCV infection – from epidemiology to clinical and fundamental virological research - and which is embedded in a multidisciplinary network of institutional, national and international collaborations.
I have been involved in several phase 1 and 2 trials with protease inhibitors or other candidate drugs. These clinical trials led to several virological ancillary studies, styding HCV resistance to direct acting antivirals.
A second research topic has been the new HCV epidemic in HIV infected MSM. Together with Prof. Dr. Prins, from the Public Health Service from Amsterdam in 2008 we successfully applied for a grant from the AIDS Fund to start the MOSAIC cohort, a multicenter cohort with the objective to study the sequellae of acute Hepatitis C virus (HCV) infection in this patient group.An interesting novel observation within this cohort was the partial immunity we observed against reinfection with the same genotype. To investigate this further we started a collaboration with Prof. Spits and Dr. Beaumont from AIMM therapeutics, with the ultimate goal of developing monoclonal antibodies against HCV (funded by the dutch government)
To obtain a more comprehensive understanding of protective immunity against HCV, transcriptomics, innate immunity and T-cell responses in the same frequently exposed non-chronic drug users from the ACS will be studied by groups we collaborate with (the group o Dr. Boonstra from the Erasmus Medical Center in Rotterdam).
Besides the topics described above I also initiated and participated studies on the molecular epidemiology of HCV. Part of this work has been done in collaboration with Prof. Pybus from Oxford University and part with Dr. T van der Laar, from the Free University of Amsterdam.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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de Jong, M., Mens, P. F., Molenkamp, R., Schinkel, C. J., Eggink, D. D., Hofstra, J. H., Koel, B. F., Matamoros, S. P. F., de Haan, K., Balraadjsing, P. P. S., Bruning, A. H. L., Cristella, C., Ginting, F., van Hattem, J. M., Hodiamont, C. J., Ho, K. Y. C., Huis in 't Veld, R. A. G., Janes, V. A., Karelehto, S. E., Merat, S. J. L., Nguyen, V. T., Omardien, S., Pawestri, H. A., Riool, M., van Someren Greve, F., Sugianli, A. K., Welkers, M. R. A., Willemse, N., Zhang, X. & Cristello, C.
1/01/2013 → …
52 Citations (Scopus)
Hepatitis C virus (HCV) antibody dynamics following acute HCV infection and reinfection among HIV-infected men who have sex with menAUTHOR GROUP, 2014, In: Clinical infectious diseases. 59, 12, p. 1678-1685
Research output: Contribution to Journal › Article › Academic › peer-review45 Citations (Scopus)
Colonial History and Contemporary Transmission Shape the Genetic Diversity of Hepatitis C Virus Genotype 2 in AmsterdamMarkov, P. V., van de Laar, T. J., Thomas, X. V., Aronson, S. J., Weegink, C. J., van den Berk, G. E., Prins, M., Pybus, O. G. & Schinkel, J., 2012, In: Journal of virology. 86, 14, p. 7677-7687
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access42 Citations (Scopus)
Alarming incidence of hepatitis C virus re-infection after treatment of sexually acquired acute hepatitis C virus infection in HIV-infected MSMAUTHOR GROUP, 2011, In: AIDS (London, England). 25, 17, p. F21-F27
Research output: Contribution to Journal › Article › Academic › peer-review119 Citations (Scopus)
Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff valuesJansen, R. R., Wieringa, J., Koekkoek, S. M., Visser, C. E., Pajkrt, D., Molenkamp, R., de Jong, M. D. & Schinkel, J., 2011, In: Journal of clinical microbiology. 49, 7, p. 2631-2636
Research output: Contribution to journal › Article › Academic › peer-review214 Citations (Scopus)