Research output per year
Research output per year
Personal profile
Research interests
I am interested in the mechanism that modulate contraction and especially relaxation. Disease such as hypertrophic cardiomyopathy (the most common inherited cardiomyopathy) and heart failure with preserved ejection fraction are characterized by impaired relaxation. The molecular pathways that control relaxation are incompletely understoond and I am to gain a better understanding of them. The aim is to translate these findings to human disease. I am currently undertaking compound screenings to find compounds and pathways that speed up relaxation.
My main techniques include: cardiomyocyte contraction/relaxation, Ca2+-transients, adult cardiomyocytes, high-throughput measurements of contraction, proteomics, protein analysis
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Master, Chemistry, Utrecht University, Utrecht, Netherlands
Award Date: 1 Jul 2003
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy
Schuldt, M., Pei, J., Harakalova, M., Dorsch, L. M., Schlossarek, S., Mokry, M., Knol, J. C., Pham, T. V., Schelfhorst, T., Piersma, S. R., Dos Remedios, C., Dalinghaus, M., Michels, M., Asselbergs, F. W., Moutin, M-J., Carrier, L., Jimenez, C. R., van der Velden, J. & Kuster, D. W. D., 1 Jan 2021, In: Circulation. Heart Failure. 14, 1, p. e007022 e007022.Research output: Contribution to journal › Article › Academic › peer-review
Open Access49 Citations (Scopus) -
GSK3 beta Phosphorylates Newly Identified Site in the Proline-Alanine-Rich Region of Cardiac Myosin-Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human
Kuster, D. W. D., Sequeira Oliveira, V., Najafi, A., Boontje, N., Wijnker, P. J. M., Witjas-Paalberends, E. R., Marston, S. B., dos Remedios, C. G., Carrier, L., Demmers, J. A. A., Redwood, C., Sadayappan, S. & van der Velden, J., 2013, In: Circulation Research. 112, 4, p. 633-639Research output: Contribution to journal › Article › Academic › peer-review
47 Citations (Scopus) -
End-diastolic force pre-activates cardiomyocytes and determines contractile force: role of titin and calcium
Najafi, A., van de Locht, M., Schuldt, M., Schönleitner, P., van Willigenburg, M., Bollen, I., Goebel, M., Ottenheijm, C. A. C., van der Velden, J., Helmes, M. & Kuster, D. W. D., 1 Sept 2019, In: Journal of physiology. 597, 17, p. 4521-4531Research output: Contribution to journal › Article › Academic › peer-review
Open Access7 Citations (Scopus) -
Large-Scale Contractility Measurements Reveal Large Atrioventricular and Subtle Interventricular Differences in Cultured Unloaded Rat Cardiomyocytes
Nollet, E. E., Manders, E. M., Goebel, M., Jansen, V., Brockmann, C., Osinga, J., van der Velden, J., Helmes, M. & Kuster, D. W. D., 21 Jul 2020, In: Frontiers in physiology. 11, 815.Research output: Contribution to journal › Article › Academic › peer-review
Open Access14 Citations (Scopus) -
Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy
Nijenkamp, L. L. A. M., Bollen, I. A. E., van Velzen, H. G., Regan, J. A., van Slegtenhorst, M., Niessen, H. W. M., Schinkel, A. F. L., Krueger, M., Poggesi, C., Ho, C. Y., Kuster, D. W. D., Michels, M. & van der Velden, J., Jun 2018, In: Circulation. Heart Failure. 11, 6, e004133.Research output: Contribution to journal › Article › Academic › peer-review
Open Access50 Citations (Scopus)