Projects per year
Personal profile
Research interests
The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovasculair disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.
We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the erea's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.
specialisation
Neurological infection and inflammatory diseases
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Lid Wetenschapscommissie NIN-KNAW, Koninklijke Nederlandse Akademie van Wetenschappen (KNAW)
1 Jan 2016 → …
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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van de Beek D.: Neuroinfection and Inflammation
van de Beek, D., Brouwer, M., Eftimov, F., van der Kooi, A., van Schaik, I., Verhamme, C., Bijlsma, M., Ferwerda, B., Valls Seron, M., Jaspers, V., Costerus, J., Dorresteijn, K., Fritz, D., Hoogland, I., Jim, K., Kasanmoentalib, E., Kloek, A., Koopmans, M., Kremer, P., Schoenmaker, N., van Veen, K., Vermeij, J., Westendorp, W., Westhoff, D., Zock, E. & Schut, E.
1/12/2010 → …
Project: Research
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Complement activation in COVID-19
Lim, E., Vlaar, A., van de Beek, D., Brouwer, M. & de Bruin, S.
Project: Research
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Community-acquired bacterial meningitis
van de Beek, D., Brouwer, M. C., Koedel, U. & Wall, E. C., 25 Sept 2021, In: Lancet. 398, 10306, p. 1171-1183 13 p.Research output: Contribution to journal › Review article › Academic › peer-review
88 Citations (Scopus) -
Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial
Vlaar, A. P. J., de Bruin, S., Busch, M., Timmermans, S. A. M. E. G., van Zeggeren, I. E., Koning, R., Ter Horst, L., Bulle, E. B., van Baarle, F. E. H. P., van de Poll, M. C. G., Kemper, E. M., van der Horst, I. C. C., Schultz, M. J., Horn, J., Paulus, F., Bos, L. D., Wiersinga, W. J., Witzenrath, M., Rueckinger, S., Pilz, K., & 6 others, Dec 2020, In: The Lancet Rheumatology. 2, 12, p. e764-e773Research output: Contribution to journal › Article › Academic › peer-review
Open Access135 Citations (Scopus) -
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank, COVID Human Genetic Effort, HGID Lab, NIAID-USUHS Immune Response to COVID Group, COVID Clinicians, COVID-STORM Clinicians, Imagine COVID Group & French COVID Cohort Study Group, 23 Oct 2020, In: Science. 370, 6515, 12 p., eabd4585.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1790 Citations (Scopus) -
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
Lees, J. A., Ferwerda, B., Kremer, P. H. C., Wheeler, N. E., Serón, M. V., Croucher, N. J., Gladstone, R. A., Bootsma, H. J., Rots, N. Y., Wijmega-Monsuur, A. J., Sanders, E. A. M., Trzciński, K., Wyllie, A. L., Zwinderman, A. H., van den Berg, L. H., van Rheenen, W., Veldink, J. H., Harboe, Z. B., Lundbo, L. F., de Groot, L. C. P. G. M., & 20 others, 1 Dec 2019, In: Nature communications. 10, 1, 2176.Research output: Contribution to journal › Article › Academic › peer-review
Open Access65 Citations (Scopus) -
ESCMID guideline: diagnosis and treatment of acute bacterial meningitis
van de Beek, D., Cabellos, C., Dzupova, O., Esposito, S., Klein, M., Kloek, A. T., Leib, S. L., Mourvillier, B., Ostergaard, C., Pagliano, P., Pfister, H. W., Read, R. C., Sipahi, O. R. & Brouwer, M. C., 2016, In: Clinical Microbiology and Infection. 22, Suppl. 3, p. S37-S62Research output: Contribution to journal › Article › Academic › peer-review
562 Citations (Scopus)
Datasets
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Additional file 2 of Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Matuozzo, D. (Creator), Talouarn, E. (Creator), Marchal, A. (Creator), Zhang, P. (Creator), Manry, J. (Creator), Seeleuthner, Y. (Creator), Zhang, Y. (Creator), Bolze, A. (Creator), Chaldebas, M. (Creator), Milisavljevic, B. (Creator), Gervais, A. (Creator), Bastard, P. (Creator), Asano, T. (Creator), Bizien, L. (Creator), Barzaghi, F. (Creator), Abolhassani, H. (Creator), Abou Tayoun, A. (Creator), Aiuti, A. (Creator), Alavi Darazam, I. (Creator), Allende, L. M. (Creator), Alonso-Arias, R. (Creator), Arias, A. A. (Creator), Aytekin, G. (Creator), Bergman, P. (Creator), Bondesan, S. (Creator), Bryceson, Y. T. (Creator), Bustos, I. G. (Creator), Cabrera-Marante, O. (Creator), Carcel, S. (Creator), Carrera, P. (Creator), Casari, G. (Creator), Chaïbi, K. (Creator), Colobran, R. (Creator), Condino-Neto, A. (Creator), Covill, L. E. (Creator), Delmonte, O. M. (Creator), El Zein, L. (Creator), Flores, C. (Creator), Gregersen, P. K. (Creator), Gut, M. (Creator), Haerynck, F. (Creator), Halwani, R. (Creator), Hancerli, S. (Creator), Hammarström, L. (Creator), Hatipoğlu, N. (Creator), Karbuz, A. (Creator), Keles, S. (Creator), Kyheng, C. (Creator), Leon-Lopez, R. (Creator), Franco, J. L. (Creator), Mansouri, D. (Creator), Martinez-Picado, J. (Creator), Metin Akcan, O. (Creator), Migeotte, I. (Creator), Morange, P. (Creator), Morelle, G. (Creator), Martin-Nalda, A. (Creator), Novelli, G. (Creator), Novelli, A. (Creator), Palabiyik, F. (Creator), Pan-Hammarström, Q. (Creator), de Diego, R. P. (Creator), Planas-Serra, L. (Creator), Pleguezuelo, D. E. (Creator), Prando, C. (Creator), Pujol, A. (Creator), Reyes, L. F. (Creator), Rivière, J. G. (Creator), Rodriguez-Gallego, C. (Creator), Rojas, J. (Creator), Rovere-Querini, P. (Creator), Schlüter, A. (Creator), Shahrooei, M. (Creator), Sobh, A. (Creator), Soler-Palacin, P. (Creator), Tandjaoui-Lambiotte, Y. (Creator), Tipu, I. (Creator), Tresoldi, C. (Creator), Troya, J. (Creator), van de Beek, D. (Creator), Zatz, M. (Creator), Zawadzki, P. (Creator), Al-Muhsen, S. Z. (Creator), Alosaimi, M. F. (Creator), Alsohime, F. M. (Creator), Baris-Feldman, H. (Creator), Butte, M. J. (Creator), Constantinescu, S. N. (Creator), Cooper, M. A. (Creator), Dalgard, C. L. (Creator), Fellay, J. (Creator), Heath, J. R. (Creator), Lau, Y. (Creator), Lifton, R. P. (Creator), Maniatis, T. (Creator), Mogensen, T. H. (Creator), von Bernuth, H. (Creator), Lermine, A. (Creator), Vidaud, M. (Creator), Boland, A. (Creator), Deleuze, J. (Creator), Nussbaum, R. (Creator), Kahn-Kirby, A. (Creator), Mentre, F. (Creator), Tubiana, S. (Creator), Gorochov, G. (Creator), Tubach, F. (Creator), Hausfater, P. (Creator), Casanova, J. (Creator), Casanova, J. (Creator), Özçelik, T. (Contributor), Meyts, I. (Creator), Zhang, S. (Creator), Puel, A. (Creator), Notarangelo, L. D. (Creator), Boisson-Dupuis, S. (Creator), Su, H. C. (Creator), Boisson, B. (Creator), Jouanguy, E. (Creator), Zhang, Q. (Creator), Abel, L. (Creator), Cobat, A. (Creator), Zhang, Y. (Creator), Asano, T. (Creator), Arias, A. A. (Creator), Bryceson, Y. T. (Creator), Flores, C. (Creator), Hammarström, L. (Creator), Franco, J. L. (Creator), Martin-Nalda, A. (Creator), Novelli, G. (Creator), Ozcelik, T. (Creator), Pujol, A. (Creator), Reyes, L. F. (Creator), Rodriguez-Gallego, C. (Creator), Schlüter, A. (Creator), Zatz, M. (Creator), Constantinescu, S. N. (Creator), Dalgard, C. L. (Creator), Heath, J. R. (Creator), Lau, Y. (Creator), Lifton, R. P. (Creator), Deleuze, J. (Creator), Su, H. C. (Creator), Casanova, J. (Creator) & Abel, L. (Creator), Figshare, 2023
DOI: 10.6084/m9.figshare.22622332.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Rare_predicted_loss-of-function_variants_of_type_I_IFN_immunity_genes_are_associated_with_life-threatening_COVID-19/22622332/1
Dataset
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Additional file 2 of Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Matuozzo, D. (Creator), Talouarn, E. (Creator), Marchal, A. (Creator), Zhang, P. (Creator), Manry, J. (Creator), Seeleuthner, Y. (Creator), Zhang, Y. (Creator), Bolze, A. (Creator), Chaldebas, M. (Creator), Milisavljevic, B. (Creator), Gervais, A. (Creator), Bastard, P. (Creator), Asano, T. (Creator), Bizien, L. (Creator), Barzaghi, F. (Creator), Abolhassani, H. (Creator), Abou Tayoun, A. (Creator), Aiuti, A. (Creator), Alavi Darazam, I. (Creator), Allende, L. M. (Creator), Alonso-Arias, R. (Creator), Arias, A. A. (Creator), Aytekin, G. (Creator), Bergman, P. (Creator), Bondesan, S. (Creator), Bryceson, Y. T. (Creator), Bustos, I. G. (Creator), Cabrera-Marante, O. (Creator), Carcel, S. (Creator), Carrera, P. (Creator), Casari, G. (Creator), Chaïbi, K. (Creator), Colobran, R. (Creator), Condino-Neto, A. (Creator), Covill, L. E. (Creator), Delmonte, O. M. (Creator), El Zein, L. (Creator), Flores, C. (Creator), Gregersen, P. K. (Creator), Gut, M. (Creator), Haerynck, F. (Creator), Halwani, R. (Creator), Hancerli, S. (Creator), Hammarström, L. (Creator), Hatipoğlu, N. (Creator), Karbuz, A. (Creator), Keles, S. (Creator), Kyheng, C. (Creator), Leon-Lopez, R. (Creator), Franco, J. L. (Creator), Mansouri, D. (Creator), Martinez-Picado, J. (Creator), Metin Akcan, O. (Creator), Migeotte, I. (Creator), Morange, P. (Creator), Morelle, G. (Creator), Martin-Nalda, A. (Creator), Novelli, G. (Creator), Novelli, A. (Creator), Palabiyik, F. (Creator), Pan-Hammarström, Q. (Creator), de Diego, R. P. (Creator), Planas-Serra, L. (Creator), Pleguezuelo, D. E. (Creator), Prando, C. (Creator), Pujol, A. (Creator), Reyes, L. F. (Creator), Rivière, J. G. (Creator), Rodriguez-Gallego, C. (Creator), Rojas, J. (Creator), Rovere-Querini, P. (Creator), Schlüter, A. (Creator), Shahrooei, M. (Creator), Sobh, A. (Creator), Soler-Palacin, P. (Creator), Tandjaoui-Lambiotte, Y. (Creator), Tipu, I. (Creator), Tresoldi, C. (Creator), Troya, J. (Creator), van de Beek, D. (Creator), Zatz, M. (Creator), Zawadzki, P. (Creator), Al-Muhsen, S. Z. (Creator), Alosaimi, M. F. (Creator), Alsohime, F. M. (Creator), Baris-Feldman, H. (Creator), Butte, M. J. (Creator), Constantinescu, S. N. (Creator), Cooper, M. A. (Creator), Dalgard, C. L. (Creator), Fellay, J. (Creator), Heath, J. R. (Creator), Lau, Y. (Creator), Lifton, R. P. (Creator), Maniatis, T. (Creator), Mogensen, T. H. (Creator), von Bernuth, H. (Creator), Lermine, A. (Creator), Vidaud, M. (Creator), Boland, A. (Creator), Deleuze, J. (Creator), Nussbaum, R. (Creator), Kahn-Kirby, A. (Creator), Mentre, F. (Creator), Tubiana, S. (Creator), Gorochov, G. (Creator), Tubach, F. (Creator), Hausfater, P. (Creator), Casanova, J. (Creator), Casanova, J. (Creator), Özçelik, T. (Contributor), Meyts, I. (Creator), Zhang, S. (Creator), Puel, A. (Creator), Notarangelo, L. D. (Creator), Boisson-Dupuis, S. (Creator), Su, H. C. (Creator), Boisson, B. (Creator), Jouanguy, E. (Creator), Zhang, Q. (Creator), Abel, L. (Creator), Cobat, A. (Creator), Zhang, Y. (Creator), Asano, T. (Creator), Arias, A. A. (Creator), Bryceson, Y. T. (Creator), Flores, C. (Creator), Hammarström, L. (Creator), Franco, J. L. (Creator), Martin-Nalda, A. (Creator), Novelli, G. (Creator), Ozcelik, T. (Creator), Pujol, A. (Creator), Reyes, L. F. (Creator), Rodriguez-Gallego, C. (Creator), Schlüter, A. (Creator), Zatz, M. (Creator), Constantinescu, S. N. (Creator), Dalgard, C. L. (Creator), Heath, J. R. (Creator), Lau, Y. (Creator), Lifton, R. P. (Creator), Deleuze, J. (Creator), Su, H. C. (Creator), Casanova, J. (Creator) & Abel, L. (Creator), Figshare, 2023
DOI: 10.6084/m9.figshare.22622332, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Rare_predicted_loss-of-function_variants_of_type_I_IFN_immunity_genes_are_associated_with_life-threatening_COVID-19/22622332
Dataset
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Supplementary Table S1 from Sequencing of the variable region of rpsB to discriminate between Streptococcus pneumoniae and other streptococcal species.
Wyllie, A. L. (Creator), Pannekoek, Y. (Creator), Bovenkerk, S. (Creator), van Engelsdorp Gastelaars, J. (Contributor), Ferwerda, B. (Creator), van de Beek, D. (Contributor), Sanders, E. A. M. (Creator), Trzciński, K. (Creator), van der Ende, A. (Contributor), Gastelaars, J. V. E. (Creator) & Beek, D. V. D. (Creator), The Royal Society, 2017
DOI: 10.6084/m9.figshare.5345950, https://rs.figshare.com/articles/dataset/Supplementary_Table_S1_from_Sequencing_of_the_variable_region_of_i_rpsB_i_to_discriminate_between_i_Streptococcus_pneumoniae_i_and_other_streptococcal_species/5345950
Dataset
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Additional file 2 of Bacterial ribosomal RNA detection in cerebrospinal fluid using a viromics approach
Kinsella, C. (Creator), Edridge, A. W. D. (Creator), van Zeggeren, I. (Creator), Deijs, M. (Creator), van de Beek, D. (Creator), Brouwer, M. (Creator), van der Hoek, L. (Creator) & Brouwer, M. C. (Creator), Figshare, 2023
DOI: 10.6084/m9.figshare.22603549, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Bacterial_ribosomal_RNA_detection_in_cerebrospinal_fluid_using_a_viromics_approach/22603549
Dataset
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Supplementary Table S1 from Sequencing of the variable region of rpsB to discriminate between Streptococcus pneumoniae and other streptococcal species
Wyllie, A. L. (Creator), Pannekoek, Y. (Creator), Bovenkerk, S. (Creator), van Engelsdorp Gastelaars, J. (Contributor), Ferwerda, B. (Creator), van de Beek, D. (Contributor), Sanders, E. A. M. (Creator), Trzciński, K. (Creator), van der Ende, A. (Contributor), Gastelaars, J. V. E. (Creator) & Beek, D. V. D. (Creator), Figshare, 2017
DOI: 10.6084/m9.figshare.5406076, https://figshare.com/articles/Supplementary_Table_S1_from_Sequencing_of_the_variable_region_of_i_rpsB_i_to_discriminate_between_i_Streptococcus_pneumoniae_i_and_other_streptococcal_species/5406076
Dataset