Daniëlle Vugts

DR., (Principal Investigator)

20032024

Research activity per year

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Personal profile

specialisation

PET radiochemistry, in particular of pharmaceuticals

Research interests

My research can be divided in three categories:

1. Immuno-PET of biopharmaceuticals

Immuno-PET imaging stands for PET imaging of antibodies and other emerging biopharmaceutical drugs and for this zirconium-89 (89Zr) is the preferred radionuclide that should be coupled stable and inertly to the biopharmaceutical via a so-called chelator. In recent years, my colleagues and I applied this in-house developed technique in numerous clinical trials supporting drug development and patient selection, and we further optimized the technology. To this end, we developed a new chelator for 89Zr, so-called DFO-star. Recently, we have shown in a preclinical setting that this new chelator is especially suited for PET imaging of antibodies used in Alzheimer’s Disease, when the antibodies are modified to be actively transported over the blood-brain-barrier (BBB). This is not possible when DFO, currently the gold standard for immuno-PET in oncology and inflammation, is used. Translational steps have been made to use this new chelator in three clinical phase I studies. Furthermore, we have developed methodologies for labeling oligonucleotides. Currently we are focussing on the labeling of new therapeutics such as cells.

2. New tracers for new targets.

At Tracer Center Amsterdam we focus on developing new PET tracers for emerging targets in oncology, neurology and immunology. The immune system plays a key role in disease progression and inflammatory targets are of great interest. In the past years my colleagues and I have successfully developed a pro-inflammatory microglial PET tracer targeting the P2X7 receptor from design to use in clinical research in MS and PD patients. In addition, we are developing a tracer targeting anti-inflammatory microglia. 

3. New radiochemistry methodologies

The radiochemistry possibilities to synthesize small molecule PET tracers are limited, and therefore not all molecules can be labeled, which hampers the use of PET during drug development. In recent years we have developed new 11C-radiolabeled reagents and methods, as well as 18F-labelled triflyl fluoride, trifluoromethane and Ruppert-Prakash reagent to introduce 11C or 18F in new efficient ways to access new PET tracers.

Education/Academic qualification

PhD, Towards the total synthesis of Mureidomycin A and a library of pyrimidine nucleoside analogs, Vrije Universiteit, Amsterdam, Netherlands

1 May 200230 Apr 2006

Award Date: 15 Dec 2006

Master, Vrije Universiteit, Amsterdam, Netherlands

1 Sept 200030 Apr 2002

Award Date: 30 Apr 2002

Hogeschool Brabant

1 Sept 199728 Feb 2001

Award Date: 28 Feb 2001

Collaborations and top research areas from the last five years

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