Projects per year
Personal profile
Research interests
Growing evidence supports a role of gut microbes in shaping host physiology and the course of chronic metabolic diseases, such as type 1 ad type 2 diabetes. The microbial metabolism of dietary components and the consequential production of a wide array of metabolites are postulated to play a major role in the microbiota-mediated regulation of host metabolic and immune responses, since microbiota-derived metabolites are sensed by host (intestinal and extra-intestinal) cells .
Nonetheless, the functions of specific bacterial communities and the impact and mechanisms of action of bacterial metabolites in the microbiota-host relationship process remain poorly understood. My research line aims to identify beneficial bacterial strains and to elucidate the effects of specific microbial metabolites (derivatives of tryptophan metabolism) on endocrine and immune cells in the context of type 1 and type 2 diabetes. For this purpose, we employ in vitro mechanistic studies as well as pre-clinical in vivo studies. Moreover, we are also conducting clinical research trials to translate our findings into the clinic.
Current funding: ZonMw VIDI, 2023; AII collaboration grant, 2022; ACS out-of-the-box, 2022&2021; ACS equipment grant, 2022, DKF innovation grant, 2021; TKI-PPP Health Holland, 2020
specialisation
Microbiota-derived signals in autoimmune and obesity-associated diabetes
Keywords
- QR180 Immunology
- innate receptors (NLRs)
- immunometabolism
- bacterial metabolites
- gut microbiota
- RB Pathology
- diabetes
- CKD
- Obesity
Collaborations and top research areas from the last five years
Projects
- 2 Active
-
Leemans J.C.: Renal Inflammation and Repair
Emal, D., Kors, L., Scantlebery, A., Tammaro, A., Leemans, J., Dessing, M., Rampanelli, E., Butter, L. & Claessen, N.
1/01/2010 → …
Project: Research
-
Florquin S.: Renal inflammation and repair
Florquin, S., Aten, J., Leemans, J., Roelofs, J., Dessing, M., Kers, J., Rampanelli, E., Stokman, G., Butter, L., Claessen, N., Bouatou, Y., Emal, D., Hoelbeek, J., Jansen, M., Kors, L., Scantlebery, A., Tammaro, A., Uil, M., Waasdorp, M. & Yapici, U.
1/01/2007 → …
Project: Research
-
Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants
Fenneman, A. C., Boulund, U., Collard, D., Galenkamp, H., Zwinderman, A. H., van den Born, B-J. H., van der Spek, A. H., Fliers, E., Rampanelli, E., Blaser, M. J. & Nieuwdorp, M., 1 Jan 2024, In: Thyroid. 34, 1, p. 101-111 11 p.Research output: Contribution to journal › Article › Academic › peer-review
-
Evidence for the contribution of the gut microbiome to obesity and its reversal
de Wit, D. F., Hanssen, N. M. J., Wortelboer, K., Herrema, H., Rampanelli, E. & Nieuwdorp, M., 22 Nov 2023, In: Science Translational Medicine. 15, 723, p. eadg2773 eadg2773.Research output: Contribution to journal › Review article › Academic › peer-review
-
Gut microbiome in type 1 diabetes: the immunological perspective
Rampanelli, E. & Nieuwdorp, M., 2023, In: Expert Review of Clinical Immunology. 19, 1, p. 93-109 17 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access4 Citations (Scopus) -
Intestinal permeability is associated with aggravated inflammation and myofibroblast accumulation in Graves’ orbitopathy: the MicroGO study
Fenneman, A. C., van der Spek, A. H., Hartstra, A., Havik, S., Salonen, A., de Vos, W. M., Soeters, M. R., Saeed, P., Nieuwdorp, M. & Rampanelli, E., 2023, In: Frontiers in Endocrinology. 14, 1173481.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Protocol for a double-blinded randomised controlled trial to assess the effect of faecal microbiota transplantations on thyroid reserve in patients with subclinical autoimmune hypothyroidism in the Netherlands: the IMITHOT trial
Fenneman, A. C., Rampanelli, E., van der Spek, A. H., Fliers, E. & Nieuwdorp, M., 14 Sept 2023, In: BMJ Open. 13, 9, p. e073971 e073971.Research output: Contribution to journal › Article › Academic › peer-review
Open Access