Floor Hugenholtz

Research output

Research output per year 2010 2016 2017 2018 2021 2023

• 43 Article
• 3 Review article
• 2 Chapter

Research output per year

Research output per year

Search results

• 2023

  Anaerobic Feces Processing for Fecal Microbiota Transplantation Improves Viability of Obligate Anaerobes

  Bénard, M. L. V., Arretxe, I. A., Wortelboer, K., Harmsen, H. J. M., Davids, M., de Bruijn, C. M. A., Benninga, M. A., Hugenholtz, F., Herrema, H. & Ponsioen, C. Y., 1 Sept 2023, In: Microorganisms. 11, 9, p. 2238 2238.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia

  ArtDeco consortium & COVID HGE consortium, Aug 2023, In: Journal of clinical immunology. 43, 6, p. 1093-1103 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  9 Citations (Scopus)
• 2022

  Bacterial and Viral Respiratory Tract Microbiota and Host Characteristics in Adults With Lower Respiratory Tract Infections: A Case-Control Study

  Haak, B. W., Brands, X., Davids, M., Peters-Sengers, H., Kullberg, R. F. J., van Houdt, R., Hugenholtz, F., Faber, D. R., Zaaijer, H. L., Scicluna, B. P., van der Poll, T. & Wiersinga, W. J., 1 Mar 2022, In: Clinical Infectious Diseases. 74, 5, p. 776-784 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  13 Citations (Scopus)

• Pro-mutagenic effects of the gut microbiota in a Lynch syndrome mouse model

  Pieters, W., Hugenholtz, F., Kos, K., Cammeraat, M., Moliej, T. C., Kaldenbach, D., Klarenbeek, S., Davids, M., Drost, L., de Konink, C., Delzenne-Goette, E., de Visser, K. E. & te Riele, H., 1 Jan 2022, In: Gut Microbes. 14, 1, p. 2035660 2035660.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Urine and vaginal microbiota compositions of postmenopausal and premenopausal women differ regardless of recurrent urinary tract infection and renal transplant status

  Hugenholtz, F., van der Veer, C., Terpstra, M. L., Borgdorff, H., van Houdt, R., Bruisten, S., Geerlings, S. E. & van de Wijgert, J. H. H. M., Dec 2022, In: Scientific reports. 12, 1, p. 2698 2698.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  17 Citations (Scopus)
• 2021

  A novel technique capable of taking ‘protected’ biopsies for reliable assessment of the distribution of microbiota along the colonic mucosa

  Strobbe, F., Bénard, M. L. V., Rossen, N. G., de Vos, W. M., Kumar, N., Lawley, T. D., Zoetendal, E. G., Hugenholtz, F. & Ponsioen, C. Y., 1 Jun 2021, In: Journal of Microbiological Methods. 185, 106204.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Disruptions of Anaerobic Gut Bacteria Are Associated with Stroke and Post-stroke Infection: a Prospective Case–Control Study

  Haak, B. W., Westendorp, W. F., van Engelen, T. S. R., Brands, X., Brouwer, M. C., Vermeij, J-D., Hugenholtz, F., Verhoeven, A., Derks, R. J., Giera, M., Nederkoorn, P. J., de Vos, W. M., van de Beek, D. & Wiersinga, W. J., Aug 2021, In: Translational Stroke Research. 12, 4, p. 581–592 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  66 Citations (Scopus)

• Gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins

  Kullberg, R. F. J., Haak, B. W., Abdel-Aziz, M. I., Davids, M., Hugenholtz, F., Nieuwdorp, M., Galenkamp, H., Prins, M., Maitland-van der Zee, A. H. & Wiersinga, W. J., 2021, In: Gut Microbes. 13, 1, 1995279.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  6 Citations (Scopus)

• Integrative Transkingdom Analysis of the Gut Microbiome in Antibiotic Perturbation and Critical Illness

  Haak, B. W., Argelaguet, R., Kinsella, C. M., Kullberg, R. F. J., Lankelma, J. M., Deijs, M., Klein, M., Jebbink, M. F., Hugenholtz, F., Kostidis, S., Giera, M., Hakvoort, T. B. M., de Jonge, W. J., Schultz, M. J., van Gool, T., van der Poll, T., de Vos, W. M., van der Hoek, L. M. & Wiersinga, W. J., 16 Mar 2021, In: mSystems. 6, 2, e01148-20.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  34 Citations (Scopus)

• Rectal bacteriome and virome signatures and clinical outcomes in community-acquired pneumonia: An exploratory study

  Kullberg, R. F. J., Hugenholtz, F., Brands, X., Kinsella, C. M., Peters-Sengers, H., Butler, J. M., Deijs, M., Klein, M., Faber, D. R., Scicluna, B. P., van der Poll, T., van der Hoek, L., Wiersinga, W. J. & Haak, B. W., Sept 2021, In: EClinicalMedicine. 39, 101074.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Spatioregional assessment of the gut microbiota in experimental necrotizing pancreatitis

  van den Berg, F. F., Hugenholtz, F., Boermeester, M. A., Zaborina, O. & Alverdy, J. C., 6 Sept 2021, In: BJS Open. 5, 5

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  10 Citations (Scopus)
• 2020

  Effect of antibiotic gut microbiota disruption on LPS-induced acute lung inflammation

  Jacobs, M. C., Lankelma, J. M., Wolff, N. S., Hugenholtz, F., de Vos, A. F., van der Poll, T. & Wiersinga, W. J., 1 Nov 2020, In: PLOS ONE. 15, 11 November, e0241748.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  19 Citations (Scopus)
• 2019

  Butyrate production in patients with end-stage renal disease

  Terpstra, M. L., Sinnige, M. J., Hugenholtz, F., Peters-Sengers, H., Remmerswaal, E. B. M., Geerlings, S. E. & Bemelman, F. J., 1 Jan 2019, In: International Journal of Nephrology and Renovascular Disease. 12, p. 87-101

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  15 Citations (Scopus)

• Identification of burkholderia Thailandensis with novel genotypes in the soil of central Sierra Leone

  Birnie, E., van’t Hof, S., Bijnsdorp, A., Mansaray, Y., Huizenga, E., van der Ende, A., Hugenholtz, F., Grobusch, M. P. & Joost Wiersinga, W., 2019, In: PLoS neglected tropical diseases. 13, 6, e0007402.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  6 Citations (Scopus)

• Long-term impact of oral vancomycin, ciprofloxacin and metronidazole on the gut microbiota in healthy humans

  Haak, B. W., Lankelma, J. M., Hugenholtz, F., Belzer, C., de Vos, W. M. & Wiersinga, W. J., 1 Jan 2019, In: Journal of antimicrobial chemotherapy. 74, 3, p. 782-786

  Research output: Contribution to journal › Article › Academic › peer-review
  74 Citations (Scopus)

• The skin microbiota in patients hospitalized for cellulitis and association with outcome

  Cranendonk, D. R., Hugenholtz, F., Prins, J. M., Savelkoul, P. H. M., Budding, A. E., Wiersinga, W. J., Hoepelman, A. I. M., Oosterheert, J. J., van Agtmael, M. A., Branger, J., Brinkman, K., Lauw, F. N., Pijlman, A. H., Sankatsing, S. U. C., Soetekouw, R., Veenstra, J. & de Vries, P. J., 8 Apr 2019, In: Clinical Infectious Diseases. 68, 8, p. 1292-1299 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  8 Citations (Scopus)
• 2018

  Changes in intestinal gene expression and microbiota composition during late pregnancy are mouse strain dependent

  Elderman, M., Hugenholtz, F., Belzer, C., Boekschoten, M., de Haan, B., de Vos, P. & Faas, M., 2018, In: Scientific reports. 8, 1, 10001.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  18 Citations (Scopus)

• Metatranscriptome analysis of the microbial fermentation of dietary milk proteins in the murine gut

  Hugenholtz, F., Davids, M., Schwarz, J., Müller, M., Tomé, D., Schaap, P., Hooiveld, G. J. E. J., Smidt, H. & Kleerebezem, M., 2018, In: PLOS ONE. 13, 4, e0194066.

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)

• Sex differences in lipid metabolism are affected by presence of the gut microbiota

  Baars, A., Oosting, A., Lohuis, M., Koehorst, M., el Aidy, S., Hugenholtz, F., Smidt, H., Mischke, M., Boekschoten, M. V., Verkade, H. J., Garssen, J., van der Beek, E. M., Knol, J., de Vos, P., van Bergenhenegouwen, J. & Fransen, F., 2018, In: Scientific reports. 8, 1, 13426.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  64 Citations (Scopus)
• 2017

  Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

  Fransen, F., van Beek, A. A., Borghuis, T., Aidy, S. E., Hugenholtz, F., van der Gaast-de Jongh, C., Savelkoul, H. F. J., de Jonge, M. I., Boekschoten, M. V., Smidt, H., Faas, M. M. & de Vos, P., 2017, In: Frontiers in immunology. 8, p. 1385

  Research output: Contribution to journal › Article › Academic › peer-review
  230 Citations (Scopus)

• Feasibility of Metatranscriptome Analysis from Infant Gut Microbiota: Adaptation to Solid Foods Results in Increased Activity of Firmicutes at Six Months

  Hugenholtz, F., Ritari, J., Nylund, L., Davids, M., Satokari, R. & de Vos, W. M., 2017, In: International journal of microbiology. 2017, p. 9547063

  Research output: Contribution to journal › Article › Academic › peer-review
  9 Citations (Scopus)

• Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/Δ7 mice

  van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O., Vermeij, W. P., Brandt, R. M. C., Barnhoorn, S., Hoeijmakers, J. H. J., de Vos, P., Leenen, P. J. M., Hendriks, R. W. & Savelkoul, H. F. J., 2017, In: Journal of leukocyte biology. 101, 4, p. 811-821

  Research output: Contribution to journal › Article › Academic › peer-review
  23 Citations (Scopus)

• High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice

  Xiao, L., Sonne, S. B., Feng, Q., Chen, N., Xia, Z., Li, X., Fang, Z., Zhang, D., Fjære, E., Midtbø, L. K., Derrien, M., Hugenholtz, F., Tang, L., Li, J., Zhang, J., Liu, C., Hao, Q., Vogel, U. B., Mortensen, A., Kleerebezem, M., & 8 othersLicht, T. R., Yang, H., Wang, J., Li, Y., Arumugam, M., Wang, J., Madsen, L. & Kristiansen, K., 2017, In: Microbiome. 5, 1, p. 43

  Research output: Contribution to journal › Article › Academic › peer-review
  115 Citations (Scopus)

• Intestinal microbiome landscaping: insight in community assemblage and implications for microbial modulation strategies

  Shetty, S. A., Hugenholtz, F., Lahti, L., Smidt, H. & de Vos, W. M., 2017, In: FEMS microbiology reviews. 41, 2, p. 182-199

  Research output: Contribution to journal › Article › Academic › peer-review
  143 Citations (Scopus)

• Metabolic in Vivo Labeling Highlights Differences of Metabolically Active Microbes from the Mucosal Gastrointestinal Microbiome between High-Fat and Normal Chow Diet

  Oberbach, A., Haange, S-B., Schlichting, N., Heinrich, M., Lehmann, S., Till, H., Hugenholtz, F., Kullnick, Y., Smidt, H., Frank, K., Seifert, J., Jehmlich, N. & von Bergen, M., 2017, In: Journal of proteome research. 16, 4, p. 1593-1604

  Research output: Contribution to journal › Article › Academic › peer-review
  23 Citations (Scopus)

• The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

  Elderman, M., Sovran, B., Hugenholtz, F., Graversen, K., Huijskes, M., Houtsma, E., Belzer, C., Boekschoten, M., de Vos, P., Dekker, J., Wells, J. & Faas, M., 2017, In: PLOS ONE. 12, 9, p. e0184274

  Research output: Contribution to journal › Article › Academic › peer-review
  91 Citations (Scopus)

• The Impact of Gut Microbiota on Gender-Specific Differences in Immunity

  Fransen, F., van Beek, A. A., Borghuis, T., Meijer, B., Hugenholtz, F., van der Gaast-de Jongh, C., Savelkoul, H. F., de Jonge, M. I., Faas, M. M., Boekschoten, M. V., Smidt, H., El Aidy, S. & de Vos, P., 2017, In: Frontiers in immunology. 8, p. 754

  Research output: Contribution to journal › Article › Academic › peer-review
  164 Citations (Scopus)

• β2→1-Fructans Modulate the Immune System In Vivo in a Microbiota-Dependent and -Independent Fashion

  Fransen, F., Sahasrabudhe, N. M., Elderman, M., Bosveld, M., El Aidy, S., Hugenholtz, F., Borghuis, T., Kousemaker, B., Winkel, S., van der Gaast-de Jongh, C., de Jonge, M. I., Boekschoten, M. V., Smidt, H., Schols, H. A. & de Vos, P., 2017, In: Frontiers in immunology. 8, p. 154

  Research output: Contribution to journal › Article › Academic › peer-review
  50 Citations (Scopus)
• 2016

  Corrigendum: The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota

  Lagkouvardos, I., Pukall, R., Abt, B., Foesel, B. U., Meier-Kolthoff, J. P., Kumar, N., Bresciani, A., Martínez, I., Just, S., Ziegler, C., Brugiroux, S., Garzetti, D., Wenning, M., Bui, T. P. N., Wang, J., Hugenholtz, F., Plugge, C. M., Peterson, D. A., Hornef, M. W., Baines, J. F., & 8 othersSmidt, H., Walter, J., Kristiansen, K., Nielsen, H. B., Haller, D., Overmann, J., Stecher, B. & Clavel, T., 2016, In: Nature Microbiology. 1, 11, p. 16219

  Research output: Contribution to journal › Article › Academic › peer-review
  9 Citations (Scopus)

• Effect of a long-term high-protein diet on survival, obesity development, and gut microbiota in mice

  Kiilerich, P., Myrmel, L. S., Fjære, E., Hao, Q., Hugenholtz, F., Sonne, S. B., Derrien, M., Pedersen, L. M., Petersen, R. K., Mortensen, A., Licht, T. R., Rømer, M. U., Vogel, U. B., Waagbø, L. J., Giallourou, N., Feng, Q., Xiao, L., Liu, C., Liaset, B., Kleerebezem, M., & 3 othersWang, J., Madsen, L. & Kristiansen, K., 2016, In: American journal of physiology. Endocrinology and metabolism. 310, 11, p. E886-E899

  Research output: Contribution to journal › Article › Academic › peer-review
  50 Citations (Scopus)

• Functional Profiling of Unfamiliar Microbial Communities Using a Validated De Novo Assembly Metatranscriptome Pipeline

  Davids, M., Hugenholtz, F., Martins dos Santos, V., Smidt, H., Kleerebezem, M. & Schaap, P. J., 2016, In: PLOS ONE. 11, 1, p. e0146423

  Research output: Contribution to journal › Article › Academic › peer-review
  16 Citations (Scopus)

• Identification of Commensal Species Positively Correlated with Early Stress Responses to a Compromised Mucus Barrier

  Sovran, B., Lu, P., Loonen, L. M. P., Hugenholtz, F., Belzer, C., Stolte, E. H., Boekschoten, M. V., van Baarlen, P., Smidt, H., Kleerebezem, M., de Vos, P., Renes, I. B., Wells, J. M. & Dekker, J., 2016, In: Inflammatory Bowel Diseases. 22, 4, p. 826-840

  Research output: Contribution to journal › Article › Academic › peer-review
  26 Citations (Scopus)

• Supplementation with Lactobacillus plantarum WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1-/Δ7 Mice

  van Beek, A. A., Sovran, B., Hugenholtz, F., Meijer, B., Hoogerland, J. A., Mihailova, V., van der Ploeg, C., Belzer, C., Boekschoten, M. V., Hoeijmakers, J. H. J., Vermeij, W. P., de Vos, P., Wells, J. M., Leenen, P. J. M., Nicoletti, C., Hendriks, R. W. & Savelkoul, H. F. J., 2016, In: Frontiers in immunology. 7, p. 408

  Research output: Contribution to journal › Article › Academic › peer-review
  51 Citations (Scopus)

• The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota

  Lagkouvardos, I., Pukall, R., Abt, B., Foesel, B. U., Meier-Kolthoff, J. P., Kumar, N., Bresciani, A., Martínez, I., Just, S., Ziegler, C., Brugiroux, S., Garzetti, D., Wenning, M., Bui, T. P. N., Wang, J., Hugenholtz, F., Plugge, C. M., Peterson, D. A., Hornef, M. W., Baines, J. F., & 8 othersSmidt, H., Walter, J., Kristiansen, K., Nielsen, H. B., Haller, D., Overmann, J., Stecher, B. & Clavel, T., 2016, In: Nature Microbiology. 1, 10, p. 16131

  Research output: Contribution to journal › Article › Academic › peer-review
  283 Citations (Scopus)
• 2015

  Comparison of the effects of five dietary fibers on mucosal transcriptional profiles, and luminal microbiota composition and SCFA concentrations in murine colon

  Lange, K., Hugenholtz, F., Jonathan, M. C., Schols, H. A., Kleerebezem, M., Smidt, H., Müller, M. & Hooiveld, G. J. E. J., 2015, In: Molecular nutrition & food research. 59, 8, p. 1590-1602

  Research output: Contribution to journal › Article › Academic › peer-review
  41 Citations (Scopus)

• IL-22-STAT3 pathway plays a key role in the maintenance of ileal homeostasis in mice lacking secreted mucus barrier

  Sovran, B., Loonen, L. M. P., Lu, P., Hugenholtz, F., Belzer, C., Stolte, E. H., Boekschoten, M. V., van Baarlen, P., Kleerebezem, M., de Vos, P., Dekker, J., Renes, I. B. & Wells, J. M., 2015, In: Inflammatory Bowel Diseases. 21, 3, p. 531-542

  Research output: Contribution to journal › Article › Academic › peer-review
  44 Citations (Scopus)

• Mining microbial metatranscriptomes for expression of antibiotic resistance genes under natural conditions

  Versluis, D., D'Andrea, M. M., Ramiro Garcia, J., Leimena, M. M., Hugenholtz, F., Zhang, J., Öztürk, B., Nylund, L., Sipkema, D., van Schaik, W., de Vos, W. M., Kleerebezem, M., Smidt, H. & van Passel, M. W. J., 2015, In: Scientific reports. 5, p. 11981

  Research output: Contribution to journal › Article › Academic › peer-review
  43 Citations (Scopus)
• 2013

  Design and analysis of a tunable synchronized oscillator

  Ryback, B. M., Odoni, D. I., van Heck, R. G., van Nuland, Y., Hesselman, M. C., Martins Dos Santos, V. A., van Passel, M. W. & Hugenholtz, F., 2013, In: Journal of biological engineering. 7, 1, p. 26

  Research output: Contribution to journal › Article › Academic › peer-review
  9 Citations (Scopus)
• 2012

  A multi-platform flow device for microbial (co-) cultivation and microscopic analysis

  Hesselman, M. C., Odoni, D. I., Ryback, B. M., de Groot, S., van Heck, R. G. A., Keijsers, J., Kolkman, P., Nieuwenhuijse, D., van Nuland, Y. M., Sebus, E., Spee, R., de Vries, H., Wapenaar, M. T., Ingham, C. J., Schroën, K., Martins dos Santos, V. A. P., Spaans, S. K., Hugenholtz, F. & van Passel, M. W. J., 2012, In: PLOS ONE. 7, 5, p. e36982

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  34 Citations (Scopus)

• Bioengineered nisin A derivatives with enhanced activity against both Gram positive and Gram negative pathogens

  Field, D., Begley, M., O'Connor, P. M., Daly, K. M., Hugenholtz, F., Cotter, P. D., Hill, C. & Ross, R. P., 2012, In: PLOS ONE. 7, 10, p. e46884

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  171 Citations (Scopus)

• Metaproteome analysis and molecular genetics of rat intestinal microbiota reveals section and localization resolved species distribution and enzymatic functionalities

  Haange, S-B., Oberbach, A., Schlichting, N., Hugenholtz, F., Smidt, H., von Bergen, M., Till, H. & Seifert, J., 2012, In: Journal of proteome research. 11, 11, p. 5406-5417

  Research output: Contribution to journal › Article › Academic › peer-review
  56 Citations (Scopus)

• The Constructor: a web application optimizing cloning strategies based on modules from the registry of standard biological parts

  Hesselman, M. C., Koehorst, J. J., Slijkhuis, T., Odoni, D. I., Hugenholtz, F. & van Passel, M. W. J., 2012, In: Journal of biological engineering. 6, 1, p. 14

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)
• 2010

  Manipulation of charged residues within the two-peptide lantibiotic lacticin 3147

  Deegan, L. H., Suda, S., Lawton, E. M., Draper, L. A., Hugenholtz, F., Peschel, A., Hill, C., Cotter, P. D. & Ross, R. P., 2010, In: Microbial biotechnology. 3, 2, p. 222-234

  Research output: Contribution to journal › Article › Academic › peer-review
  20 Citations (Scopus)