Projects per year
Personal profile
Research interests
My research focusses on the metabolism of complex lipids and their role in genetic disease, acquired disorders and aging. Lipid metabolism is a relatively uncharted territory but the etiology of many diseases, both mono- and polygenic, is increasingly associated with (disturbances of) complex lipid metabolism. Highlights of my research efforts include the discovery of new inborn errors of (lipid) metabolism (NTCP, PCYT2 deficiency) and the development of a newborn screening test for cerebrotendinous xanthomatosis (CTX), a disorder of bile acid synthesis, which hopefully will allow the introduction of this disorder in the Dutch neonatal screening program.
My group’s focus is broadening as we also are involved in trying to understand the metabolic perturbations of communal and acquired disorders such as heart disease and diabetes as part of large consortia including CVON (Energise!). More recently, we have also started collaborations investigating the lipidome of infectious diseases as meningitis and COVID-19. To study complex lipid metabolism it is required to be able to comprehensively analyze lipids in various biological matrices. For this reason, over the last 20 years my group has developed and used state-of-the-art technological metabolomics/lipidomics platforms. With the aid of research technology grants we have acquired 2 new innovative mass spectrometers which we have used to develop leading lipidomics and metabolomics platforms that are increasingly applied in search of disease biomarkers and functional characterization of model systems. An important aspect that we are pioneering together with bioinformaticians in our group is the development of suitable data processing and representation software for this type of complex data. Combining these aspects with an in depth knowledge of metabolism allows the characterization of metabolism and detailed analysis of its perturbation by disease, also beyond genetic disorders.
Specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
Projects
- 1 Active
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Wanders R.J.A.: Focus of research
van de Beek, M., Chatzispyrou, I. A., Daniels, E. G., van Engen, C. E., Falkenberg, K. D., Gao, W., Held, N. M., Herzog, K., Khan, R. R., Schackmann, M. J. A., Liu, J., Wanders, R. J. A., Ferdinandusse, S., Kulik, W., van Roermund, C. W. T., Vaz, F. M., Houtkooper, R. H. L., te Brinke, H., Denis, S. W. & IJlst, L.
1/01/2007 → …
Project: Research
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Newborn screening for Cerebrotendinous Xanthomatosis: A retrospective biomarker study using both flow-injection and UPLC-MS/MS analysis in 20,000 newborns
Vaz, F. M., Jamal, Y., Barto, R., Gelb, M. H., DeBarber, A. E., Wevers, R. A., Nelen, M. R., Verrips, A., Bootsma, A. H., Bouva, M. J., Kleise, N., van der Zee, W., He, T., Salomons, G. S. & Huidekoper, H. H., 15 Jan 2023, In: Clinica chimica acta. 539, p. 170-174 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Sex-specific newborn screening for X-linked adrenoleukodystrophy
Albersen, M., van der Beek, S. L., Dijkstra, I. M. E., Alders, M., Barendsen, R. W., Bliek, J., Boelen, A., Ebberink, M. S., Ferdinandusse, S., Goorden, S. M. I., Heijboer, A. C., Jansen, M., Jaspers, Y. R. J., Metgod, I., Salomons, G. S., Vaz, F. M., Verschoof-Puite, R. K., Visser, W. F., Dekkers, E., Engelen, M., & 1 others , 17 Jan 2023, In: Journal of Inherited Metabolic Disease. 46, 1, p. 116-128Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown
Sailer, S., Lackner, K., Pras-Raves, M. L., Wever, E. J. M., van Klinken, J. B., Dane, A. D., Geley, S., Koch, J., Golderer, G., Werner-Felmayer, G., Keller, M. A., Zwerschke, W., Vaz, F. M., Werner, E. R. & Watschinger, K., 1 Jun 2022, In: Journal of lipid research. 63, 6, 100222.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
An improved functional assay in blood spot to diagnose Barth syndrome using the monolysocardiolipin/cardiolipin ratio
Vaz, F. M., van Lenthe, H., Vervaart, M. A. T., Stet, F. S., Klinkspoor, J. H., Vernon, H. J., Goorden, S. M. I., Houtkooper, R. H., Kulik, W. & Wanders, R. J. A., Jan 2022, In: Journal of Inherited Metabolic Disease. 45, 1, p. 29-37 9 p.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access6 Citations (Scopus) -
Barth syndrome and the many fascinating aspects of cardiolipin
Vaz, F. M., Wanders, R. J. A. & Vernon, H., Jan 2022, In: Journal of Inherited Metabolic Disease. 45, 1, p. 1-2 2 p.Research output: Contribution to Journal › Editorial › Academic › peer-review
Open Access