Projects per year
Personal profile
Research interests
Frederik Barkhof received his MD from VU University, Amsterdam (NL) in 1988 and defended his PhD thesis in 1992, for which he received the Philips Prize for Radiology (1992) and the Lucien Appel Prize for Neuroradiology (1994). Since 2001 he serves as a full Professor in Neuroradiology at the department of Radiology & Nuclear Medicine at VUmc. In 2015 he was appointed as full Professor of Neuroradiology at institutes of Biomedical Engineering and Neurology at UCL in London (UK) to translate novel imaging techniques. In 2018 he received the John Dystel prize by the US National MS Society and the American Academy of Neurology outstanding contributions to research in MS. In 2019, he became a senior fellow of the ISMRM
Prof. Barkhof was the chairman of the Dutch Society of Neuroradiology and the MAGNIMS study group for many years. He is leading the Queen Square MS Centre Trial Unit, involved in analysis of multicentre drug trials. He serves on the Editorial boards of Radiology, Brain, Multiple Sclerosis Journal, Neuroradiology and Neurology. He is a fellow of the Royal College of Radiology.
His research interests focus on childhood white matter disease, multiple sclerosis, ageing and dementia. He (co)authored >1100 papers referenced in PubMed, has an H-factor of 164 (Google Scholar) with >110,000 citations and is listed among 3000 most influential scientists world-wide by Thompson-Reuters. He is the author of the books “Neuroimaging in Dementia”, “Clinical applications of functional brain MRI” and “Clinical Neuroradiology – the ESNR textbook”
Cumulatively, he has received >30 million euro grant money from various national and international funding agencies and performed contract research for all major pharmaceutical companies with cumulative contract value of >15 million euro. More than 40 PhD students graduated under his supervision and 5 of them have subsequently attained a full professorship
External positions
Professor of Neuroradiology, UCL Institute of Neurology
1 Oct 2014 → …
Collaborations and top research areas from the last five years
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GLIOCARE
Keil, V., Wamelink, I., Azizova, A., Barkhof, F., Mutsaerts, H., Petr, J., de Witt Hamer, P., Wesseling, P. & Kouwenhoven, M.
1/04/2022 → …
Project: Research
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IMAGO - Imaging in Glioma
Keil, V., Wamelink, I., Barkhof, F. & Verburg, N.
1/07/2021 → …
Project: Research
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BIG-BBB: BBB-ASL for injection-free Glioma Blood Brain Barrier assessment
Mutsaerts, H., Keil, V., Petr, J., Wink, A. M., de Witt Hamer, P., Barkhof, F., Lavini, C. & Wamelink, I.
Project: Research
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ExploreASL
Mutsaerts, H., Esteves Padrela, B., Petr, J., Barkhof, F., Dijsselhof, M. & Groot, P.
Project: Research
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DEBBIE: Developing a non-invasive biomarker for early BBB breakdown in Alzheimer’s disease
Mutsaerts, H., Petr, J., Barkhof, F., Esteves Padrela, B., Günther, M., Lawson, U. A., Achten, R. & Fladby, T.
Project: Research
Research output
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A Fully Automated Deep-Learning Model for Predicting the Molecular Subtypes of Posterior Fossa Ependymomas Using T2-Weighted Images
Cheng, D., Zhuo, Z., du, J., Weng, J., Zhang, C., Duan, Y., Sun, T., Wu, M., Guo, M., Hua, T., Jin, Y., Peng, B., Li, Z., Zhu, M., Imami, M., Bettegowda, C., Sair, H., Bai, H. X., Barkhof, F., Liu, X., & 1 others , 10 Jan 2024, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 30, 1, p. 150-158 9 p.Research output: Contribution to journal › Article › Academic › peer-review
1 Citation (Scopus) -
Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure
Tranfa, M., Lorenzini, L., Collij, L. E., Vállez García, D., Ingala, S., Pontillo, G., Pieperhoff, L., Maranzano, A., Wolz, R., Haller, S., Blennow, K., Frisoni, G., Sudre, C. H., Chételat, G., Ewers, M., Payoux, P., Waldman, A., Martinez-Lage, P., Schwarz, A. J., Ritchie, C. W., & 6 others , Jun 2024, In: Annals of clinical and translational neurology. 11, 6, p. 1541-1556 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients
Biesbroek, J. M., Coenen, M., DeCarli, C., Fletcher, E. M., Maillard, P. M., Barkhof, F., Barnes, J., Benke, T., Chen, C. P. L. H., Dal-Bianco, P., Dewenter, A., Duering, M., Enzinger, C., Ewers, M., Exalto, L. G., Franzmeier, N., Hilal, S., Hofer, E., Koek, H. L., Maier, A. B., & 20 others , 1 Apr 2024, In: Alzheimer's and Dementia. 20, 4, p. 2980-2989 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
An efficient semi-supervised quality control system trained using physics-based MRI-artefact generators and adversarial training
Ravi, D. & Alzheimer's Disease Neuroimaging Initiative, 1 Jan 2024, In: Medical Image Analysis. 91, 103033.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Applicability of multiple quantitative magnetic resonance methods in genetic brain white matter disorders
Stellingwerff, M. D., Al-Saady, M. L., Chan, K-S., Dvorak, A., Marques, J. P., Kolind, S., Roosendaal, S. D., Wolf, N. I., Barkhof, F., van der Knaap, M. S. & Pouwels, P. J. W., 1 Jan 2024, In: Journal of neuroimaging. 34, 1, p. 61-77 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus)
Datasets
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Data from: Cognitive reserve and clinical progression in Alzheimer’s disease: a paradoxical relationship
van Loenhoud, A. (Creator), van der Flier, W. (Creator), Wink, A. M. (Creator), Dicks, E. (Creator), Groot, C. (Creator), Twisk, J. (Creator), Barkhof, F. (Creator), Scheltens, P. (Creator), Ossenkoppele, R. (Creator) & Scheltens, P. (Creator), Dryad, 23 Nov 2019
DOI: 10.5061/dryad.cb0qk1g, https://datadryad.org/stash/dataset/doi:10.5061/dryad.cb0qk1g
Dataset
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Data from: Cognitive reserve and clinical progression in Alzheimer's disease: a paradoxical relationship
van Loenhoud, A. (Contributor), van der Flier, W. (Contributor), Wink, A. M. (Contributor), Dicks, E. (Contributor), Groot, C. (Contributor), Twisk, J. (Contributor), Barkhof, F. (Contributor), Scheltens, P. (Contributor), Ossenkoppele, R. (Contributor) & Scheltens, P. (Contributor), Zenodo, 23 Nov 2019
DOI: 10.5061/dryad.cb0qk1g, https://zenodo.org/record/4955054
Dataset