Projects per year
Personal profile
specialisation
Multiple Sclerosis, Ethiology, Myelin, Neurodegeneration, Axo-Myelinic Synapse
Research interests
As a neuroscientist I am passionate about the brain. Two central research questions, from which numerous smaller questions are derived, are
1) How does multiple sclerosis start?
2) What happens in the brain at a cellular and molecular level when (MS) patients show imaging-measured network changes and concomitant cognitive deterioration?
Both questions are helping us to understand (MS) disease mechanisms in more detail, with the eventual aim of designing curative therapies.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Finished
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Blistering of the axon-myelin unit as prodromal stage of axonal degeneration in progressive MS: the role of calpain-cathepsin axis.
Luchicchi, A., Schenk, G. & Meijns, N.
1/09/2021 → 31/05/2023
Project: Research
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Micro-diffusely abnormal white matter: An early multiple sclerosis lesion phase with intensified myelin blistering
Luchicchi, A., Muñoz-Gonzalez, G., Halperin, S. T., Strijbis, E., van Dijk, L. H. M., Foutiadou, C., Uriac, F., Bouman, P. M., Schouten, M. A. N., Plemel, J., 't Hart, B. A., Geurts, J. J. G. & Schenk, G. J., 29 Feb 2024, (E-pub ahead of print) In: Annals of clinical and translational neurology.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Inhibitory synaptic loss drives network changes in multiple sclerosis: An ex vivo to in silico translational study
Huiskamp, M., Kiljan, S., Kulik, S., Witte, M. E., Jonkman, L. E., GJM Bol, J., Schenk, G. J., Hulst, H. E., Tewarie, P., Schoonheim, M. M. & Geurts, J. J. G., 1 Nov 2022, In: MULTIPLE SCLEROSIS JOURNAL. 28, 13, p. 2010-2019 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access6 Citations (Scopus) -
The Forgotten Brother: The Innate-like B1 Cell in Multiple Sclerosis
Halperin, S. T., ’t Hart, B. A., Luchicchi, A. & Schenk, G. J., 1 Mar 2022, In: Biomedicines. 10, 3, 606.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus) -
Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination
Ghorbani, S., Jelinek, E., Jain, R., Buehner, B., Li, C., Lozinski, B. M., Sarkar, S., Kaushik, D. K., Dong, Y., Wight, T. N., Karimi-Abdolrezaee, S., Schenk, G. J., Strijbis, E. M., Geurts, J., Zhang, P., Ling, C-C. & Yong, V. W., 1 Dec 2022, In: Nature communications. 13, 1, 2445.Research output: Contribution to journal › Article › Academic › peer-review
Open Access18 Citations (Scopus) -
Axon-Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter
Luchicchi, A., Hart, B., Frigerio, I., van Dam, A-M., Perna, L., Offerhaus, H. L., Stys, P. K., Schenk, G. J. & Geurts, J. J. G., Apr 2021, In: Annals of neurology. 89, 4, p. 711-725 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access35 Citations (Scopus)