Research output per year
Research output per year
Personal profile
Research interests
My research is aimed to understand the molecular mechanisms that contribute to hematopoietic stem cell (HSC) functioning.
A small population of selfrenewing HSCs ensures that all the various types of blood cells are produced during the lifetime of an organism. Nevertheless, during aging blood cell production is impaired, resulting in either a deficit of blood cells (leading to anemia, thromocytopenia, or susceptibility to infections) or an excess of blood cells (myeloproliferative diseases or leukemias).
The identification of the molecular machinery that is associated with aberrant selfrenewal of aged HSCs should allow the development of interventions that improve or restore selfrenewal of normal aged stem cells, and that target exessive selfrenewal of leukemic stem cells.
specialisation
Hematology, Stem cells, Aging, Leukemia
Education/Academic qualification
Bijzonder hoogleraar met de leeropdracht Moleculaire Stamcelbiologie, University of Amsterdam, Netherlands
1 Mar 2022 → …
External positions
Directeur research Sanquin, Sanquin
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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How CBX proteins regulate normal and leukemic blood cells
de Groot, A. P. & de Haan, G., 2024, (E-pub ahead of print) In: FEBS letters.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access -
3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice
Guerrero, A., Innes, A. J., Roux, P-F., Buisman, S. C., Jung, J., Ortet, L., Moiseeva, V., Wagner, V., Robinson, L., Ausema, A., Potapova, A., Perdiguero, E., Weersing, E., Aarts, M., Martin, N., Wuestefeld, T., Muñoz-Cánoves, P., de Haan, G., Bischof, O. & Gil, J., Sept 2022, In: Nature Aging. 2, 9, p. 851-866 16 p.Research output: Contribution to journal › Article › Academic › peer-review
3 Citations (Scopus) -
Is the philosopher’s stone to rejuvenate blood stem cells an epigenetic regulator?
Svendsen, A. F. & de Haan, G., 1 Nov 2022, In: Nature Aging. 2, 11, p. 980-981 2 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity
Kim, K. M., Mura-Meszaros, A., Tollot, M., Krishnan, M. S., Gründl, M., Neubert, L., Groth, M., Rodriguez-Fraticelli, A., Svendsen, A. F., Campaner, S., Andreas, N., Kamradt, T., Hoffmann, S., Camargo, F. D., Heidel, F. H., Bystrykh, L. V., de Haan, G. & von Eyss, B., 1 Dec 2022, In: Nature communications. 13, 1, 5187.Research output: Contribution to journal › Article › Academic › peer-review
Open Access8 Citations (Scopus) -
The developmental stage of the medulloblastoma cell-of-origin restricts Sonic hedgehog pathway usage and drug sensitivity
Smit, M. J., Martini, T. E. I., Armandari, I., Bočkaj, I., Zomerman, W. W., de Camargo Magãlhaes, E. S., Siragna, Z., Meeuwsen, T. G. J., Scherpen, F. J. G., Schoots, M. H., Ritsema, M., den Dunnen, W. F. A., Hoving, E. W., Paridaen, J. T. M. L., de Haan, G., Guryev, V. & Bruggeman, S. W. M., 1 Jun 2022, In: Journal of Cell Science. 135, 11, jcs258608.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus)