Clinical Research:

• Projects:
  • Pathophysiology of inherited and acquired cardiac arrhythmias, e.g., Brugada syndrome, Long QT syndrome, drug-induced arrhythmias
  • Genetic basis and clinical determinants of inherited heart disease, in particular, primary arrhythmia syndromes, sudden cardiac death, and cardiomyopathies
  • Electrophysiological and structural remodeling in right ventricular failure
  • Genetic basis of congenital structural heart disease
•  Methods:
  • Noninvasive cardiac electrophysiology: body surface mapping
  • Invasive cardiac electrophysiology: electrophysiologic study, epicardial mapping during cardiac surgery
  • Imaging: echocardiography

Basic Research:

• Projects:
  • Molecular basis of right ventricular failure
  • Ion channel remodeling in congestive heart failure
  • Biophysical characterization of variant ion channels in primary arrhythmia syndromes
  • Development of a bio-engineered cardiac pacemaker
•  Methods:
  • Patch-clamp studies of isolated myocytes and transfected cell cultures
  • Electrical and optical activation mapping
  • Viral transduction of cultured myocytes
  • Imaging: echocardiography