Han Tan

(Principal Investigator), PhD

1993 …2022

Research activity per year

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Personal profile

Research interests

Clinical Research:

  • Projects:
    • Pathophysiology of inherited and acquired cardiac arrhythmias, e.g., Brugada syndrome, Long QT syndrome, drug-induced arrhythmias
    • Genetic basis and clinical determinants of inherited heart disease, in particular, primary arrhythmia syndromes, sudden cardiac death, and cardiomyopathies
    • Electrophysiological and structural remodeling in right ventricular failure
    • Genetic basis of congenital structural heart disease
  •  Methods:
    • Noninvasive cardiac electrophysiology: body surface mapping
    • Invasive cardiac electrophysiology: electrophysiologic study, epicardial mapping during cardiac surgery
    • Imaging: echocardiography


Basic Research:

  • Projects:
    • Molecular basis of right ventricular failure
    • Ion channel remodeling in congestive heart failure
    • Biophysical characterization of variant ion channels in primary arrhythmia syndromes
    • Development of a bio-engineered cardiac pacemaker
  •  Methods:
    • Patch-clamp studies of isolated myocytes and transfected cell cultures
    • Electrical and optical activation mapping
    • Viral transduction of cultured myocytes
    • Imaging: echocardiography

Specialisation

Cardiology, Cardiogenetics

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