Projects per year
Personal profile
Research interests
I'm a postdoctoral Researcher at Amsterdam UMC in the field of immunometabolism. My research interest is to understand which metabolic fuels and pathways are essential for B- and T-cells in chronic lymphocytic leukemia, and to use this knowledge to uncover new therapeutic targets and improve T-cell based therapies for this disease.
Education/Academic qualification
PhD, Exploring the regulation and function of TIGAR in cancer cells
1 Jan 2015 → 5 Jul 2019
Award Date: 5 Jul 2019
Master, Biomedical Sciences, Basic and Translational Cancer Research, Barcelona - Universityersitat de Barcelona
Sept 2013 → Jul 2014
Bachelor, Biomedical Sciences, Barcelona - Universityersitat de Barcelona
Sept 2009 → Sept 2013
External positions
Researcher and Teaching Assistant, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona
Oct 2018 → Oct 2020
Visiting PhD student, Beatson Institute for Cancer Research
Apr 2016 → Jul 2016
PhD student Biomedical Sciences Program, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona
Feb 2015 → Jul 2019
Keywords
- QR180 Immunology
- QP Physiology
- metabolism
- immunometabolism
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
- CLL
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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Exploit altered lipid metabolism to improve T-cell function in chronic lymphocytic leukemia (Cancer Center Amsterdam grant, round 2023)
1/03/2024 → 1/03/2026
Project: Research
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Electron transport chain and mTOR inhibition synergistically decrease CD40 signaling and counteract venetoclax resistance in chronic lymphocytic leukemia
Chen, Z., Cretenet, G., Carnazzo, V., Simon-Molas, H., Kater, A. P., Windt, G. J. W. V. D. & Eldering, E., 1 Jan 2024, In: Haematologica. 109, 1, p. 151-162 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
Metabolic reprogramming in the CLL TME; potential for new therapeutic targets
Simon-Molas, H., Montironi, C., Kabanova, A. & Eldering, E., 15 Feb 2024, In: Seminars in Hematology.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
T-cell dysfunction by pseudohypoxia and autocrine purinergic signaling in chronic lymphocytic leukemia
Montironi, C., Jacobs, C. F., Cretenet, G., Peters, F. S., Schomakers, B. V., van Weeghel, M., Kater, A. P., Simon-Molas, H. & Eldering, E., 2023, In: Blood advances. 7, 21, p. 6540-6552 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment
Chen, Z., Simon-Molas, H., Cretenet, G., Valle-Argos, B., Smith, L. D., Forconi, F., Schomakers, B. V., van Weeghel, M., Bryant, D. J., van Bruggen, J. A. C., Peters, F. S., Rathmell, J. C., van der Windt, G. J. W., Kater, A. P., Packham, G. & Eldering, E., 11 Aug 2022, In: Blood. 140, 6, p. 630-643 14 p.Research output: Contribution to journal › Article › Academic › peer-review
16 Citations (Scopus) -
TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Is Upregulated in Lymphocytes Stimulated with Concanavalin A
Simon-Molas, H., Vallvé-Martínez, X., Caldera-Quevedo, I., Fontova, P., Arnedo-Pac, C., Vidal-Alabró, A., Castaño, E., Navarro-Sabaté, À., Lloberas, N., Bartrons, R. & Manzano, A., 11 Jul 2021, In: International journal of molecular sciences. 22, 14Research output: Contribution to journal › Article › Academic › peer-review