Henk-Jan Mutsaerts

DR., MD, (Principal Investigator)


Research activity per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Henk (Henri JMM) Mutsaerts is an MD PhD with a passion for image processing. His research focuses on the development of arterial spin labeling (ASL) perfusion MRI as a biomarker in brain aging and dementia, and is stratified in three trajectories: 1) standardization, 2) interpretation, and 3) application of ASL as a cerebrovascular biomarker. 

  1. Standardization includes the development and standardization of image analysis to improve multi-center reproducibility. Henk leads the development of the worldwide-used open-source software ExploreASL, ASL-BIDS, and the standardization and automation of neuroimaging quality control.
  2. Interpretation entails the discovery of (patho-)physiological components in the ASL perfusion signal, focusing on vascular efficiency, brain atrophy, brain aging, and the blood-brain barrier permeability.
  3. Application of ASL as biomarker in clinical research (current impact), pharmaceutical trials (near-future impact) clinical radiological practice (future impact) to bridge research and clinical practice, also through collaborations with companies such as Gold Standard Phantoms, IXICO, mediri, QMenta, Philips Healthcare.


image analysis; cerebral hemodynamics; magnetic resonance imaging; brain aging; dementia

Education/Academic qualification

PhD, Arterial spin labeling, reproducibility and clinical applications, Academic Medical Center, Amsterdam, Netherlands

1 Apr 201126 Mar 2015

Award Date: 26 Mar 2015

Master, Noninvasive assessment of vulnerable plaque development with MRI, Leiden University Medical Center - LUMC

1 Sept 200230 Mar 2009

Award Date: 30 Mar 2009

External positions

Honorary lecturer, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.

1 Jan 2020 → …

Research associate, Ghent University Hospital, Ghent, Belgium.

1 Jan 2019 → …

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or