Projects per year
Personal profile
Research interests
Henk (Henri JMM) Mutsaerts is an MD PhD with a passion for image processing. His research focuses on the development of arterial spin labeling (ASL) perfusion MRI as a biomarker in brain aging and dementia, and is stratified in three trajectories: 1) standardization, 2) interpretation, and 3) application of ASL as a cerebrovascular biomarker.
- Standardization includes the development and standardization of image analysis to improve multi-center reproducibility. Henk leads the development of the worldwide-used open-source software ExploreASL, ASL-BIDS, and the standardization and automation of neuroimaging quality control.
- Interpretation entails the discovery of (patho-)physiological components in the ASL perfusion signal, focusing on vascular efficiency, brain atrophy, brain aging, and the blood-brain barrier permeability.
- Application of ASL as biomarker in clinical research (current impact), pharmaceutical trials (near-future impact) clinical radiological practice (future impact) to bridge research and clinical practice, also through collaborations with companies such as Gold Standard Phantoms, IXICO, mediri, QMenta, Philips Healthcare.
specialisation
image analysis; cerebral hemodynamics; magnetic resonance imaging; brain aging; dementia
Education/Academic qualification
PhD, Arterial spin labeling, reproducibility and clinical applications, Academic Medical Center, Amsterdam, Netherlands
1 Apr 2011 → 26 Mar 2015
Award Date: 26 Mar 2015
Master, Noninvasive assessment of vulnerable plaque development with MRI, Leiden University Medical Center - LUMC
1 Sept 2002 → 30 Mar 2009
Award Date: 30 Mar 2009
External positions
Honorary lecturer, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.
1 Jan 2020 → …
Research associate, Ghent University Hospital, Ghent, Belgium.
1 Jan 2019 → …
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SANE-QC: TKI-PPP - Standardization and Automation of NEuroimaging QC
1/09/2022 → 1/09/2026
Project: Research
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GLIOCARE
Keil, V., Wamelink, I., Azizova, A., Barkhof, F., Mutsaerts, H., Petr, J., de Witt Hamer, P., Wesseling, P. & Kouwenhoven, M.
1/04/2022 → …
Project: Research
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BIG-BBB: BBB-ASL for injection-free Glioma Blood Brain Barrier assessment
Mutsaerts, H., Keil, V., Petr, J., Wink, A. M., de Witt Hamer, P., Barkhof, F., Lavini, C. & Wamelink, I.
Project: Research
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ExploreASL
Mutsaerts, H., Esteves Padrela, B., Petr, J., Barkhof, F., Dijsselhof, M. & Groot, P.
Project: Research
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DEBBIE: Developing a non-invasive biomarker for early BBB breakdown in Alzheimer’s disease
Mutsaerts, H., Petr, J., Barkhof, F., Esteves Padrela, B., Günther, M., Lawson, U. A., Achten, R. & Fladby, T.
Project: Research
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Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure
Tranfa, M., Lorenzini, L., Collij, L. E., Vállez García, D., Ingala, S., Pontillo, G., Pieperhoff, L., Maranzano, A., Wolz, R., Haller, S., Blennow, K., Frisoni, G., Sudre, C. H., Chételat, G., Ewers, M., Payoux, P., Waldman, A., Martinez-Lage, P., Schwarz, A. J., Ritchie, C. W., & 6 others, Jun 2024, In: Annals of clinical and translational neurology. 11, 6, p. 1541-1556 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
A systematic review of (semi-)automatic quality control of T1-weighted MRI scans
Hendriks, J., Mutsaerts, H-J., Joules, R., Peña-Nogales, Ó., Rodrigues, P. R., Wolz, R., Burchell, G. L., Barkhof, F. & Schrantee, A., 1 Jan 2024, In: Neuroradiology. 66, 1, p. 31-42 12 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access1 Citation (Scopus) -
Brain Tumor Imaging without Gadolinium-based Contrast Agents: Feasible or Fantasy?
Wamelink, I. J. H. G., Azizova, A., Booth, T. C., Mutsaerts, H. J. M. M., Ogunleye, A., Mankad, K., Petr, J., Barkhof, F. & Keil, V. C., 1 Feb 2024, In: Radiology. 310, 2, p. e230793Research output: Contribution to journal › Review article › Academic › peer-review
1 Citation (Scopus) -
Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer's disease (DEBBIE-AD): a prospective observational multicohort study protocol
Padrela, B., Mahroo, A., Tee, M., Sneve, M. H., Moyaert, P., Geier, O., Kuijer, J. P. A., Beun, S., Nordhøy, W., Zhu, Y. D., Buck, M. A., Hoinkiss, D. C., Konstandin, S., Huber, J. R., Wiersinga, J., Rikken, R., de Leeuw, D., Grydeland, H. K., Tippett, L., Cawston, E. E., & 23 others, 8 Mar 2024, In: BMJ Open. 14, 3, e081635.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Improving advanced intraoperative MRI methods during pediatric neurosurgery
Jellema, P. E. J., Mannsdörfer, L. M., Visser, F., de Luca, A., Smit, C. L. E., Hoving, E. W., van Baarsen, K. M., Lindner, T., Mutsaerts, H-J. M. M., Dankbaar, J. W., Lequin, M. H. & Wijnen, J. P., Jun 2024, In: NMR in biomedicine. 37, 6, e5124.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Datasets
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Supplementary Material for: Cerebral Lesions on 7 Tesla MRI in Patients with Sickle Cell Anemia
Van Der Land, V. (Creator), Zwanenburg, J. J. M. (Contributor), Fijnvandraat, K. (Creator), Biemond, B. J. (Creator), Hendrikse, J. (Creator), Mutsaerts, H. (Contributor), Visser, F. (Creator), Wardlaw, J. M. (Creator), Nederveen, A. (Creator), Majoie, C. (Contributor), Mutsaerts, H. J. M. M. (Contributor) & Majoie, C. B. L. M. (Contributor), Karger Publishers, 2015
DOI: 10.6084/m9.figshare.5127616.v1, https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Cerebral_Lesions_on_7_Tesla_MRI_in_Patients_with_Sickle_Cell_Anemia/5127616/1
Dataset
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Supplementary Material for: Cerebral Lesions on 7 Tesla MRI in Patients with Sickle Cell Anemia
Van Der Land, V. (Creator), Zwanenburg, J. J. M. (Contributor), Fijnvandraat, K. (Creator), Biemond, B. J. (Creator), Hendrikse, J. (Creator), Mutsaerts, H. (Contributor), Visser, F. (Creator), Wardlaw, J. M. (Creator), Nederveen, A. (Creator), Majoie, C. (Contributor), Mutsaerts, H. J. M. M. (Contributor) & Majoie, C. B. L. M. (Contributor), Karger Publishers, 2015
DOI: 10.6084/m9.figshare.5127616, https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Cerebral_Lesions_on_7_Tesla_MRI_in_Patients_with_Sickle_Cell_Anemia/5127616
Dataset
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Second assessor Sanjhana Bhusal Pediatric optic nerve glioma: identification of radiologic biomarkers by manual segmention and comparison to conventionel tumor diameter measurements
Henk-Jan Mutsaerts (Examiner)
2023Activity: PhD thesis Examination › Examination › Educational
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International Society for Magnetic Resonance in Medicine (ISMRM) (External organisation)
Henk-Jan Mutsaerts (Member)
2023 → 2024Activity: Membership › Membership of board › Academic
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Second assessor Ieke Geelen Polygenic risk scores and associated pathways regulating cerebrospinal fluid amyloid-β1-42 and P-tau181 in early Alzheimer’s disease
Henk-Jan Mutsaerts (Examiner)
2023Activity: PhD thesis Examination › Examination › Educational
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PhD/doctorate committee: dr. I.T. Hovden, Structural and functional tracking in longitudinal magnetic resonance imaging of glioblastoma University of Oslo, Oslo, Norway
Henk-Jan Mutsaerts (Examiner)
2023Activity: PhD thesis Examination › Examination › Educational
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Second assessor Maud Sijm, Medical Natural Sciences, AUMC, location VUmc, Validation of an image-based method for retrieval of total body weight and 18F-FDG activity from half-body 18F-FDG PET/CT scans in calculation of SUV
Henk-Jan Mutsaerts (Examiner)
2023Activity: PhD thesis Examination › Examination › Educational