Research output per year
Research output per year
Personal profile
Research interests
Founder and PI of the N=You neurodevelopmental precision center at the Emma Children's Hospital in the Amsterdam UMC partnering with Levvel. The multi-transdisciplinary team of N=You focusses on the development and implementation of personalized mechanism-based treatments for neurodevelopmental disorders. The cornerstone of our approach is to match each individual child to the most optimal available n-of-1 therapy design by the integration of genetic, cellular (IPSC), neurophysiological (EEG) and cognitive diagnostic information.
Keywords
- RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
- autism spectrum disorders
- personalized medicine
- n-of-1 trials
- neurodevelopmental disorders
- bumetanide
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Prediction of Behavioral Improvement Through Resting-State Electroencephalography and Clinical Severity in a Randomized Controlled Trial Testing Bumetanide in Autism Spectrum Disorder
Juarez-Martinez, E. L., Sprengers, J. J., Cristian, G., Oranje, B., van Andel, D. M., Avramiea, A. E., Simpraga, S., Houtman, S. J., Hardstone, R., Gerver, C., Jan van der Wilt, G., Mansvelder, H. D., Eijkemans, M. J. C., Linkenkaer-Hansen, K. & Bruining, H., Sep 2021, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access10 Citations (Scopus) -
The sensory-reactivity PROM set: identification of a parent reported outcome measure set for autism spectrum disorder
van Andel, D. M., van Stel, H. F., Scheepers, F. E., Oostrom, K. J., Haverman, L. & Bruining, H., 1 Dec 2021, In: Journal of Patient-Reported Outcomes. 5, 1, 123.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Measurement of excitation-inhibition ratio in autism spectrum disorder using critical brain dynamics
Bruining, H., Hardstone, R., Juarez-Martinez, E. L., Sprengers, J., Avramiea, A. E., Simpraga, S., Houtman, S. J., Poil, S. S., Dallares, E., Palva, S., Oranje, B., Matias Palva, J., Mansvelder, H. D. & Linkenkaer-Hansen, K., 8 Jun 2020, In: Scientific reports. 10, 1, p. 1-15 15 p., 9195.Research output: Contribution to journal › Article › Academic › peer-review
Open Access44 Citations (Scopus) -
Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase-2 Superiority Trial
Sprengers, J., Van Andel, D. M., Zuithoff, N. P. A., Keijzer-Veen, M. G., Schulp, A. J. A., Scheepers, F. E., Lilien, M. R., Oranje, B. & Bruining, H., Jul 2021, In: Journal of the American Academy of Child and Adolescent Psychiatry. 60, 7, p. 865-876 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access40 Citations (Scopus) -
STXBP1 Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG
Houtman, S. J., Lammertse, H. C. A., van Berkel, A. A., Balagura, G., Gardella, E., Ramautar, J. R., Reale, C., Møller, R. S., Zara, F., Striano, P., Misra-Isrie, M., van Haelst, M. M., Engelen, M., van Zuijen, T. L., Mansvelder, H. D., Verhage, M., Bruining, H. & Linkenkaer-Hansen, K., 23 Dec 2021, In: Frontiers in physiology. 12, December, p. 1-17 17 p., 775172.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus)
Press/Media
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de Morgen - interview over bumetanide en predictie algoritme
15/11/2021
1 Media contribution
Press/Media: Interview
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Interview Vrij Nederland on precision psychiatry
17/06/2020
1 Media contribution
Press/Media: Interview