Hilgo Bruining

Research output

Research output per year 2009 2021 2022 2023 2024

• 38 Article
• 5 Comment/Letter to the editor
• 5 Review article
• 2 Letter
• 1 More
  • 1 Chapter

Research output per year

Research output per year

Search results

• 2024

  Cannabidiol (Epidyolex®) for severe behavioral manifestations in patients with tuberous sclerosis complex, mucopolysaccharidosis type III and fragile X syndrome: protocol for a series of randomized, placebo-controlled N-of-1 trials

  Müller, A. R., den Hollander, B., van de Ven, P. M., Roes, K. C. B., Geertjens, L., Bruining, H., van Karnebeek, C. D. M., Jansen, F. E., de Wit, M. C. Y., Ten Hoopen, L. W., Rietman, A. B., Dierckx, B., Wijburg, F. A., Boot, E., Brands, M. M. G. & van Eeghen, A. M., 1 Dec 2024, In: BMC psychiatry. 24, 1, p. 23 23.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2023

  Changes in child and adolescent mental health across the COVID-19 pandemic (2018–2023): Insights from general population and clinical samples in the Netherlands

  van Oers, H. A., Alrouh, H., Tieskens, J. M., Luijten, M. A. J., de Groot, R., Broek, E., van der Doelen, D., Klip, H., De Meyer, R., van der Mheen, M., Ruisch, I. H., van den Berg, G., Bruining, H., Buitelaar, J., van der Rijken, R., Hoekstra, P. J., Kleinjan, M., Lindauer, R., Oostrom, K. J., Staal, W., & 7 othersVermeiren, R., Cornet, R., Haverman, L., Popma, A., Bartels, M., Polderman, T. J. C. & Zijlmans, J., 2023, In: JCPP Advances. n/a, n/a, p. e12213

  Research output: Contribution to journal › Article › Academic › peer-review

• Effectiveness of L-serine supplementation in children with a GRIN2B loss-of-function mutation: Rationale and protocol for single patient (n-of-1) multiple cross-over trials.

  den Hollander, B., Rothuizen-Lindenschot, M., Geertjens, L., Vaz, F. M., Brands, M. M., le, H. L., van Eeghen, A. M., van de Ven, P. M., Cornel, M. C., Jacobs, B. A. W., Bruining, H. & van Karnebeek, C. D., 1 Dec 2023, In: Contemporary Clinical Trials Communications. 36, p. 101233 101233.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Effects of Bumetanide on Neurocognitive Functioning in Children with Autism Spectrum Disorder: Secondary Analysis of a Randomized Placebo-Controlled Trial

  van Andel, D. M., Sprengers, J. J., Königs, M., de Jonge, M. V. & Bruining, H., 2023, (E-pub ahead of print) In: Journal of Autism and Developmental Disorders.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Internalizing problems before and during the COVID-19 pandemic in independent samples of Dutch children and adolescents with and without pre-existing mental health problems

  Fischer, K., Tieskens, J. M., Luijten, M. A. J., Zijlmans, J., van Oers, H. A., de Groot, R., van der Doelen, D., van Ewijk, H., Klip, H., van der Lans, R. M., de Meyer, R., van der Mheen, M., van Muilekom, M. M., Hyun Ruisch, I., Teela, L., van den Berg, G., Bruining, H., van der Rijken, R., Buitelaar, J., Hoekstra, P. J., & 9 othersLindauer, R., Oostrom, K. J., Staal, W., Vermeiren, R., Cornet, R., Haverman, L., Bartels, M., Polderman, T. J. C. & Popma, A., Oct 2023, In: European Child and Adolescent Psychiatry. 32, 10, p. 1873-1883 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  11 Citations (Scopus)

• Prediction of Behavioral Improvement Through Resting-State Electroencephalography and Clinical Severity in a Randomized Controlled Trial Testing Bumetanide in Autism Spectrum Disorder

  Juarez-Martinez, E. L., Sprengers, J. J., Cristian, G., Oranje, B., van Andel, D. M., Avramiea, A. E., Simpraga, S., Houtman, S. J., Hardstone, R., Gerver, C., Jan van der Wilt, G., Mansvelder, H. D., Eijkemans, M. J. C., Linkenkaer-Hansen, K. & Bruining, H., Mar 2023, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 8, 3, p. 251-261 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  20 Citations (Scopus)

• Profiles of autism characteristics in thirteen genetic syndromes: a machine learning approach

  Bozhilova, N., Welham, A., Adams, D., Bissell, S., Bruining, H., Crawford, H., Eden, K., Nelson, L., Oliver, C., Powis, L., Richards, C., Waite, J., Watson, P., Rhys, H., Wilde, L., Woodcock, K. & Moss, J., 1 Dec 2023, In: Molecular autism. 14, 1, 3.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  6 Citations (Scopus)

• The effects of COVID-19 on child mental health: Biannual assessments up to April 2022 in a clinical and two general population samples

  Zijlmans, J., Tieskens, J. M., van Oers, H. A., Alrouh, H., Luijten, M. A. J., de Groot, R., van der Doelen, D., Klip, H., van der Lans, R. M., de Meyer, R., van der Mheen, M., Hyun Ruisch, I., van den Berg, G., Bruining, H., Buitelaar, J., van der Rijken, R., Hoekstra, P. J., Kleinjan, M., Lindauer, R. J. L., Oostrom, K. J., & 7 othersStaal, W., Vermeiren, R., Cornet, R., Haverman, L., Popma, A., Bartels, M. & Polderman, T. J. C., Jun 2023, In: JCPP Advances. 3, 2, p. e12150 14 p., e12150.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2022

  Assessing the landscape of STXBP1-related disorders in 534 individuals

  Xian, J., Parthasarathy, S., Ruggiero, S. M., Balagura, G., Fitch, E., Helbig, K., Gan, J., Ganesan, S., Kaufman, M. C., Ellis, C. A., Lewis-Smith, D., Galer, P., Cunningham, K., O'Brien, M., Cosico, M., Baker, K., Darling, A., Veiga de Goes, F., El Achkar, C. M., Doering, J. H., & 34 othersFuria, F., García-Cazorla, Á., Gardella, E., Geertjens, L., Klein, C., Kolesnik-Taylor, A., Lammertse, H., Lee, J., Mackie, A., Misra-Isrie, M., Olson, H., Sexton, E., Sheidley, B., Smith, L., Sotero, L., Stamberger, H., Syrbe, S., Thalwitzer, K. M., van Berkel, A., van Haelst, M., Yuskaitis, C., Weckhuysen, S., Prosser, B., Son Rigby, C., Demarest, S., Pierce, S., Zhang, Y., Møller, R. S., Bruining, H., Poduri, A., Zara, F., Verhage, M., Striano, P. & Helbig, I., 1 May 2022, In: Brain : a journal of neurology. 145, 5, p. 1668-1683 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  33 Citations (Scopus)

• Bumetanide Effects on Resting-State EEG in Tuberous Sclerosis Complex in Relation to Clinical Outcome: An Open-Label Study

  Juarez-Martinez, E. L., van Andel, D. M., Sprengers, J. J., Avramiea, A-E., Oranje, B., Scheepers, F. E., Jansen, F. E., Mansvelder, H. D., Linkenkaer-Hansen, K. & Bruining, H., 12 May 2022, In: Frontiers in neuroscience. 16, May, p. 1-13 13 p., 879451.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• Bumetanide for Irritability in Children With Sensory Processing Problems Across Neurodevelopmental Disorders: A Pilot Randomized Controlled Trial

  van Andel, D. M., Sprengers, J. J., Keijzer-Veen, M. G., Schulp, A. J. A., Lillien, M. R., Scheepers, F. E. & Bruining, H., 8 Feb 2022, In: Frontiers in psychiatry. 13, 780281.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)

• Following Excitation/Inhibition Ratio Homeostasis from Synapse to EEG in Monogenetic Neurodevelopmental Disorders

  Geertjens, L., van Voorst, T. W., Bouman, A., van Boven, M. A., Kleefstra, T., Verhage, M., Linkenkaer-Hansen, K., Kasri, N. N., Cornelisse, L. N. & Bruining, H., Feb 2022, In: Genes. 13, 2, p. 1-10 10 p., 390.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Improved Manual Annotation of EEG Signals through Convolutional Neural Network Guidance

  Diachenko, M., Houtman, S. J., Juarez-Martinez, E. L., Ramautar, J. R., Weiler, R., Mansvelder, H. D., Bruining, H., Bloem, P. & Linkenkaer-Hansen, K., Oct 2022, In: eNeuro. 9, 5, p. 1-14 14 p., ENEURO.0160-22.2022.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Resting-state network organisation in children with traumatic brain injury

  Botchway, E., Kooper, C. C., Pouwels, P. J. W., Bruining, H., Engelen, M., Oosterlaan, J. & Königs, M., 1 Sept 2022, In: Cortex. 154, p. 89-104 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Single-case experimental designs for bumetanide across neurodevelopmental disorders: BUDDI protocol: BUDDI protocol

  Geertjens, L., Cristian, G., Haspels, E., Ramautar, J., van der Wilt, G. J., Verhage, M. & Bruining, H., 7 Jul 2022, In: BMC psychiatry. 22, 1, p. 1-11 11 p., 452.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Towards PErsonalised PRognosis for children with traumatic brain injury: the PEPR study protocol

  Kooper, C. C., Oosterlaan, J., Bruining, H., Engelen, M., Pouwels, P. J. W., Popma, A., van Woensel, J. B. M., Buis, D. R., Steenweg, M. E., Hunfeld, M. & Königs, M., 1 Jun 2022, In: BMJ Open. 12, 6, p. e058975 e058975.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)
• 2021

  Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase-2 Superiority Trial

  Sprengers, J., Van Andel, D. M., Zuithoff, N. P. A., Keijzer-Veen, M. G., Schulp, A. J. A., Scheepers, F. E., Lilien, M. R., Oranje, B. & Bruining, H., Jul 2021, In: Journal of the American Academy of Child and Adolescent Psychiatry. 60, 7, p. 865-876 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  59 Citations (Scopus)

• EEG-based visual deviance detection in freely behaving mice

  Kat, R., Berg, B. V. D., Perenboom, M. JL., Schenke, M., Maagdenberg, A. MJM. V. D., Bruining, H., Tolner, E. A. & Kas, M. JH., 15 Dec 2021, In: NEUROIMAGE. 245, 118757.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• STXBP1 Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG

  Houtman, S. J., Lammertse, H. C. A., van Berkel, A. A., Balagura, G., Gardella, E., Ramautar, J. R., Reale, C., Møller, R. S., Zara, F., Striano, P., Misra-Isrie, M., van Haelst, M. M., Engelen, M., van Zuijen, T. L., Mansvelder, H. D., Verhage, M., Bruining, H. & Linkenkaer-Hansen, K., 23 Dec 2021, In: Frontiers in physiology. 12, December, p. 1-17 17 p., 775172.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  12 Citations (Scopus)

• The sensory-reactivity PROM set: identification of a parent reported outcome measure set for autism spectrum disorder

  van Andel, D. M., van Stel, H. F., Scheepers, F. E., Oostrom, K. J., Haverman, L. & Bruining, H., 1 Dec 2021, In: Journal of Patient-Reported Outcomes. 5, 1, 123.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)
• 2020

  Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: An open-label pilot study

  Van Andel, D. M., Sprengers, J. J., Oranje, B., Scheepers, F. E., Jansen, F. E. & Bruining, H., 7 May 2020, In: Molecular autism. 11, 1, 30.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  38 Citations (Scopus)

• LifeTime and improving European healthcare through cell-based interceptive medicine

  LifeTime Community & LifeTime Community Working Groups, 19 Nov 2020, In: NATURE. 587, 7834, p. 377-386 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  87 Citations (Scopus)

• Measurement of excitation-inhibition ratio in autism spectrum disorder using critical brain dynamics

  Bruining, H., Hardstone, R., Juarez-Martinez, E. L., Sprengers, J., Avramiea, A. E., Simpraga, S., Houtman, S. J., Poil, S. S., Dallares, E., Palva, S., Oranje, B., Matias Palva, J., Mansvelder, H. D. & Linkenkaer-Hansen, K., 8 Jun 2020, In: Scientific reports. 10, 1, p. 1-15 15 p., 9195.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  80 Citations (Scopus)
• 2019

  Loss of Cntnap2 Causes Axonal Excitability Deficits, Developmental Delay in Cortical Myelination, and Abnormal Stereotyped Motor Behavior

  Scott, R., Sánchez-Aguilera, A., Van Elst, K., Lim, L., Dehorter, N., Bae, S. E., Bartolini, G., Peles, E., Kas, M. J. H., Bruining, H. & Marín, O., 1 Feb 2019, In: Cerebral cortex. 29, 2, p. 586-597 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  51 Citations (Scopus)
• 2018

  Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice

  Molenhuis, R. T., Bruining, H., Brandt, M. J. V., Van Soldt, P. E., Abu-Toamih Atamni, H. J., Burbach, J. P. H., Iraqi, F. A., Mott, R. F. & Kas, M. J. H., 13 Dec 2018, In: Molecular autism. 9, 1, 63.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  19 Citations (Scopus)
• 2017

  Behavioral disinhibition and antiepileptic treatment in childhood epilepsy: A retrospective cohort study

  van Tuijl, D. C., Groenwold, R. H. H., Vlaskamp, C., van Campen, J. S., Braun, K. P. J., Jansen, F. E. & Bruining, H., 1 Mar 2017, In: Epilepsia Open. 2, 1, p. 59-66 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Scopus)
• 2015

  Genetic mapping in mice reveals the involvement of Pcdh9 in long-term social and object recognition and sensorimotor development

  Bruining, H., Matsui, A., Oguro-Ando, A., Kahn, R. S., Van'T Spijker, H. M., Akkermans, G., Stiedl, O., Van Engeland, H., Koopmans, B., Van Lith, H. A., Oppelaar, H., Tieland, L., Nonkes, L. J., Yagi, T., Kaneko, R., Burbach, J. P. H., Yamamoto, N., Kas, M. J. & Nonkes, LJ., 1 Oct 2015, In: Biological Psychiatry. 78, 7, p. 485-495 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  31 Citations (Scopus)

• Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography

  van Diessen, E., Senders, J., Jansen, F. E., Boersma, M. & Bruining, H., 21 Sept 2015, In: European archives of psychiatry and clinical neuroscience. 265, 6, p. 537-540 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  60 Citations (Scopus)

• Sensory modulation disorders in childhood epilepsy

  Van Campen, J. S., Jansen, F. E., Kleinrensink, N. J., Joëls, M., Braun, K. P. J. & Bruining, H., 23 Oct 2015, In: Journal of neurodevelopmental disorders. 7, 1, 34.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  18 Citations (Scopus)
• 2014

  Behavioral signatures related to genetic disorders in autism

  Bruining, H., Eijkemans, M. J., Kas, M. J., Curran, S. R., Vorstman, J. A. & Bolton, P. F., 11 Feb 2014, In: Molecular autism. 5, 1, 11.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  60 Citations (Scopus)

• Enhancing the value of psychiatric mouse models; differential expression of developmental behavioral and cognitive profiles in four inbred strains of mice

  Molenhuis, R. T., de Visser, L., Bruining, H. & Kas, M. J., Jun 2014, In: European neuropsychopharmacology. 24, 6, p. 945-954 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  24 Citations (Scopus)

• The social behavioral phenotype in boys and girls with an extra X chromosome (Klinefelter syndrome and Trisomy X): A comparison with autism spectrum disorder

  Van Rijn, S., Stockmann, L., Borghgraef, M., Bruining, H., Van Ravenswaaij-Arts, C., Govaerts, L., Hansson, K. & Swaab, H., Feb 2014, In: Journal of Autism and Developmental Disorders. 44, 2, p. 310-320 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  58 Citations (Scopus)
• 2012

  Sex-dependent novelty response in neurexin-1α mutant mice

  Laarakker, M. C., Reinders, N. R., Bruining, H., Ophoff, R. A. & Kas, M. J. H., 13 Feb 2012, In: PLOS ONE. 7, 2, e31503.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  39 Citations (Scopus)

• Vulnerability for autism traits in boys and men with an extra X chromosome (47,XXY): The mediating role of cognitive flexibility

  van Rijn, S., Bierman, M., Bruining, H. & Swaab, H., Oct 2012, In: Journal of Psychiatric Research. 46, 10, p. 1300-1306 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  25 Citations (Scopus)
• 2011

  In search for significant cognitive features in klinefelter syndrome through cross-species comparison of a supernumerary x chromosome

  Bruining, H., Swaab, H., de Sonneville, L. M. J., van Rijn, S., van Engeland, H. & Kas, M. J. H., 1 Aug 2011, In: Genes, Brain and Behavior. 10, 6, p. 658-662 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  10 Citations (Scopus)
• 2010

  Dissecting the clinical heterogeneity of autism spectrum disorders through defined genotypes

  Bruining, H., de Sonneville, L., Swaab, H., de Jonge, M., Kas, M., van Engeland, H. & Vorstman, J., 17 Sept 2010, In: PLOS ONE. 5, 5, e10887.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  74 Citations (Scopus)

• The parent-of-origin of the extra X chromosome may differentially affect psychopathology in klinefelter syndrome

  Bruining, H., Van Rijn, S., Swaab, H., Giltay, J., Kates, W., Kas, M. J. H., Van Engeland, H. & De Sonneville, L., 15 Dec 2010, In: Biological Psychiatry. 68, 12, p. 1156-1162 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  24 Citations (Scopus)
• 2009

  Psychiatric characteristics in a self-selected sample of boys with klinefelter syndrome

  Bruining, H., Swaab, H., Kas, M. & Van Engeland, H., 1 May 2009, In: Pediatrics. 123, 5, p. e865-e870

  Research output: Contribution to journal › Article › Academic › peer-review
  154 Citations (Scopus)