20022024

Research activity per year

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Personal profile

Research interests

The topic of my research is model-based personalized medicine in oncology/hematology. My overall research ambition stems from the need to improve efficacy and reduce toxicity of anticancer drug therapy through the application of quantitative pharmacology. In my research, I aim to use pharmacokinetic/pharmacodynamic (PKPD) modeling to integrate information on systemic exposure, tissue penetration, cellular and/or molecular engagement and expression of pharmacological activity with long term response (efficacy & toxicity). I authored more than 55 manuscripts in peer-reviewed journals (>20 as first/last author) in the field of  target site pharmacokinetic-pharmacodynamic modeling to optimize cancer treatment.

 

For this research goal, we have established a network of researchers interested in target site penetration measurements, with expertise in therapeutic plasma PK-sampling, PET scans using inert radiolabeled small molecule radiopharmaceuticals, real-time MRI perfusion scans and structured databases of clinical outcomes. Here, we combine relevant preclinical mechanistic data of physicochemical drug properties related to PK and efficacy/toxicity, pathologic and physiological factors and apply mathematics to describe the mechanisms that control the uptake, distribution, and elimination of drug into blood and (tumor) tissues. When adequately evaluated using relevant and quantified target site-measurements, this information can bridge the gap between the therapeutic regimen and the pharmacological link with clinical outcome.

 

specialisation

Small molecules, oncology & hematology, model-based personalized medicine, pharmacokinetic/pharmacodynamic (PKPD) modeling,  physiology-based pharmacokinetic modeling

Education/Academic qualification

Clinical Pharmacologist, Amsterdam UMC

1 Apr 20181 Mar 2020

Award Date: 1 Mar 2020

Bachelor, Pharmaceutical sciences, Utrecht University, Utrecht, Netherlands

1 Sept 19951 Feb 2002

Award Date: 1 Feb 2020

Clinical Pharmacologist (USA)

1 Mar 20151 Mar 2017

Award Date: 1 Mar 2017

PhD, Individualization of drug exposure in pediatric hematopoietic stem cell transplantation, University Medical Center Utrecht

1 Jan 200819 Apr 2012

Award Date: 19 Apr 2012

Hospital Pharmacist, UMC Utrecht

1 Jan 200512 Jan 2009

Award Date: 12 Jan 2009

Master, Pharmacy, Utrecht University, Utrecht, Netherlands

1 Feb 20001 May 2002

Award Date: 1 May 2002

Keywords

  • RM Therapeutics. Pharmacology
  • Oncology
  • Pharmacokinetics-Pharmacodynamics
  • Physiology Based Pharmacokinetic modeling (PBPK)
  • Therapeutic Drug Monitoring
  • personalised medicine

Collaborations and top research areas from the last five years

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