Projects per year
Personal profile
Research interests
I am a behavioral neuroscientist with a background in functional neuroanatomy. I am interested in how our brain controls motivated behavior and why we sometimes lose that control. My scientific focus lies on how release of the neurotransmitter dopamine (and other neuromodulators such as serotonin) regulates cortico-basal ganglia networks under normal (e.g., reinforcement learning, decision making), as well as pathological conditions (e.g., OCD, drug addiction). My research group pursues these goals by collecting a range of neurobiological measurements in awake behaving rodents (voltammetry, electrophysiology, calcium imaging etc.) and by probing neural mechanisms with optogenetic, chemogenetic, and pharmacological interventions.
We study how the brain produces automatic and habitual actions (behavior outside of conscious control), and how dysregulation of such actions may contribute to compulsive behavior, a common denominator to several neuro-psychiatric disorders such as OCD, addictions, and eating disorders. Compulsive behavior may occur due to dysregulation of several individual behavioral functions (components), such as cognitive flexibility and habit formation. We study compulsive behavior itself, a variety of its presumed components, and their brain mechanisms in rodents, but in the long run, our research is intended to lead to novel insights that improve psychiatric therapy in human patients.
Specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
Projects
- 2 Active
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Willuhn I.: The neurocircuitry of compulsive behavior
van den Boom, B. J. G., Derksen, M., Ehmer, I., van Elzelingen, W., Goedhoop, J. N., Willuhn, I., Arbab, T., Faust, R. & Burgeno, L.
31/03/2015 → …
Project: Research
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Denys D.A.J.P.: Deep Brain Stimulation and Obsessive-Compulsive Disorders
Denys, D. A. J. P., Derks, E. M., Figee, M., Roelfsema, P. R., Vulink, N. C. C., Willuhn, I., Bais, M. N., Bangel, K., van Bennekom, M. J., Bergfeld, I. O., Blom, R. M., van den Boom, B. J. G., Cerrone, K. C., Derksen, M., van Diepen, R. M., ten Doesschate, F., Domen, A. C., Ehmer, I., van Elzelingen, W., Goedhoop, J. N., Goldschmidt, T. F., de Haan, M. I. C., Jager, I. J., Kasanmoentalib, A. S., Kuipers, L. J. H., van Leeuwen, W. A., Levar, N., Liebrand, L. C., Molenaar, C. A. B., Ooms, P., Oudijn, M. S., Polak, R. R., van der Pol, M. M., Scheepens, D. S., Schroder, A. E., Smolders, R., van der Straten, A. L., Strous, J. F. M., Turbyne, C. A., van Westen, M. M., Zantvoord, J. B., Turner, R., van der Linden, M., Matilla, T. & Schippers, R.
1/07/2011 → …
Project: Research
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Excessive cocaine use results from decreased phasic dopamine signaling in the striatum
Willuhn, I., Burgeno, L. M., Groblewski, P. A. & Phillips, P. E. M., 2014, In: Nature neuroscience. 17, 5, p. 704-709Research output: Contribution to journal › Article › Academic › peer-review
146 Citations (Scopus) -
Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use
Willuhn, I., Burgeno, L. M., Everitt, B. J. & Phillips, P. E. M., 2012, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109, 50, p. 20703-20708Research output: Contribution to journal › Article › Academic › peer-review
174 Citations (Scopus) -
Phasic dopamine release in the nucleus accumbens in response to pro-social 50 kHz ultrasonic vocalizations in rats
Willuhn, I., Tose, A., Wanat, M. J., Hart, A. S., Hollon, N. G., Phillips, P. E. M., Schwarting, R. K. W. & Wöhr, M., 2014, In: Journal of neuroscience. 34, 32, p. 10616-10623Research output: Contribution to journal › Article › Academic › peer-review
106 Citations (Scopus) -
A selective role for dopamine in stimulus-reward learning
Flagel, S. B., Clark, J. J., Robinson, T. E., Mayo, L., Czuj, A., Willuhn, I., Akers, C. A., Clinton, S. M., Phillips, P. E. M. & Akil, H., 2011, In: NATURE. 469, 7328, p. 53-57Research output: Contribution to journal › Article › Academic › peer-review
671 Citations (Scopus) -
Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals
Clark, J. J., Sandberg, S. G., Wanat, M. J., Gan, J. O., Horne, E. A., Hart, A. S., Akers, C. A., Parker, J. G., Willuhn, I., Martinez, V., Evans, S. B., Stella, N. & Phillips, P. E. M., 2010, In: Nature Methods. 7, 2, p. 126-129Research output: Contribution to journal › Article › Academic › peer-review
265 Citations (Scopus)