Research output per year
Research output per year
Personal profile
Research interests
My PhD project focuses on using PET/CT imaging as a predictive biomarker for response to
immunotherapy, and on evaluating novel therapeutics such as nanoparticles or antibodydrug
conjugates using this technique. PET/CT imaging is a non-invasive tool that produces
qualitative as well as quantitative data on tumor uptake and biodistribution, while
simultaneously allowing for heterogeneity analysis and repetitive measurements.
Applying PET/CT imaging as a potential biomarker for immunotherapy requires a
translational approach and a close collaboration has been achieved within the Cancer Center
Amsterdam to match PET results to pathology and flow cytometry results.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Master, Master of Oncology, VUmc School of Medical Sciences, Amsterdam.
Award Date: 20 Jun 2018
Master, Geneeskunde, VUmc School of Medical Sciences, Amsterdam.
Award Date: 15 Aug 2017
Bachelor, Geneeskunde, VUmc School of Medical Sciences, Amsterdam.
Award Date: 26 Oct 2013
Keywords
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
- PET/CT imaging
- immunotherapy
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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89Zr-immuno-PET using the anti-LAG-3 tracer [89Zr]Zr-BI 754111: demonstrating target specific binding in NSCLC and HNSCC
Miedema, I. H. C., Huisman, M. C., Zwezerijnen, G. J. C., Grempler, R., Pitarch, A. P., Thiele, A., Hesse, R., Elgadi, M., Peltzer, A., Vugts, D. J., van Dongen, G. A. M. S., de Gruijl, T. D., Menke-van der Houven van Oordt, C. W. & Bahce, I., Jun 2023, In: European journal of nuclear medicine and molecular imaging. 50, 7, p. 2068-2080 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access12 Citations (Scopus) -
89Zr-Immuno-PET with Immune Checkpoint Inhibitors: Measuring Target Engagement in Healthy Organs
Miedema, I. H. C., Wijngaarden, J. E., Pouw, J. E. E., Zwezerijnen, G. J. C., Sebus, H. J., Smit, E., de Langen, A. J., Bahce, I., Thiele, A., Vugts, D. J., Boellaard, R., Huisman, M. C. & Menke-van der Houven van Oordt, C. W., 1 Dec 2023, In: Cancers. 15, 23, 5546.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
89Zr-DFO-Durvalumab PET/CT Before Durvalumab Treatment in Patients with Recurrent or Metastatic Head and Neck Cancer
Verhoeff, S., van de Donk, P. P., Aarntzen, E. H., Oosting, S. F., Brouwers, A. H., Miedema, IHC., Voortman, J., Menke, C. W., Boellaard, R., Vriens, D., Slingerland, M., Hermsen, R., van Engen-van Grunsven, I. A. C. H., Heskamp, S. & van Herpen, C. M. L., 1 Oct 2022, In: Journal of nuclear medicine. 63, 10, p. 1523-1530 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access16 Citations (Scopus) -
Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles
Rijcken, C. J. F., de Lorenzi, F., Biancacci, I., Hanssen, R. G. J. M., Thewissen, M., Hu, Q., Atrafi, F., Liskamp, R. M. J., Mathijssen, R. H. J., Miedema, I. H. C., Menke - van der Houven van Oordt, C. W., van Dongen, G. A. M. S., Vugts, D. J., Timmers, M., Hennink, W. E. & Lammers, T., 1 Dec 2022, In: Advanced drug delivery reviews. 191, 114613.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access8 Citations (Scopus) -
PET‐CT Imaging of Polymeric Nanoparticle Tumor Accumulation in Patients
Miedema, IHC., Zwezerijnen, GJC., Huisman, MC., Doeleman, E., Mathijssen, R. H. J., Lammers, T., Hu, Q., van Dongen, G., Rijcken, C., Vugts, DJ. & Menke, C. W., 26 May 2022, In: Advanced materials. 34, 21, 2201043.Research output: Contribution to journal › Article › Academic › peer-review
Open Access16 Citations (Scopus)