Projects per year
Personal profile
Research interests
The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovasculair disorders, and movement disorders. .The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.
Neuroinfection & inflammation
Our neuromuscular centre is a NFU (Nederlandse federatie van universitaire medische centra) and ERN (European reference network) accredited center for neuromuscular diseases in general, and motor neuron disease (ALS), idiopathic inflammatory myopathy, poliomyelitis, hereditary neuropathies and inflammatory polyneuropathies in particular. Inflammatory diseases of peripheral nerves and muscles are the main focus of the neuromuscular research-line, within the research area neuro-infection and inflammation. The immune mediated neuropathies (e.g. GBS, CIDP, MMN) and idiopathic inflammatory myopathies (e.g. dermatomysositis, IBM) and critical illness neuropathy and myopathy are the specific diseases of interest. This research is patient-driven and translational. More specific, clinical trials, cohort studies and studies investigating immunological and genomic characterization of nerve and muscle inflammation are performed. From these studies we try to arrive at clinically relevant biomarkers of disease activity and predictors of response. For the critical illness neuromyopathies early predictors for disease and outcome are sought.
Improving the diagnostic and therapeutic options available to these patients are thus the starting point. The prevention of nerve and muscle damage and the improvement of the regenerative capacity are some of the key areas for the near future.
specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
CEO, Stichting Sanquin Bloedvoorziening
1 Oct 2022 → …
Collaborations and top research areas from the last five years
Projects
- 2 Active
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Horn J.: Neurology on the Intensive Care Unit
Horn, J., Hauck, N., Hollmann, M., Juffermans, N., Lagrand, W., Lirk, P., Nollet, F., Preckel, B., van der Schaaf, M., van Schaik, I., Schultz, M., Stevens, M., Verhamme, C., Zuurbier, C., Brevoord, D., Kerindongo, R., Admiraal, M., Sommers, J., Witteveen, E., Hofmeijer, J., van Putten, M. J. A. M., Ruijter, B. & van der Veen, A. J.
1/01/2013 → …
Project: Research
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van de Beek D.: Neuroinfection and Inflammation
van de Beek, D., Brouwer, M., Eftimov, F., van der Kooi, A., van Schaik, I., Verhamme, C., Bijlsma, M., Ferwerda, B., Valls Seron, M., Jaspers, V., Costerus, J., Dorresteijn, K., Fritz, D., Hoogland, I., Jim, K., Kasanmoentalib, E., Kloek, A., Koopmans, M., Kremer, P., Schoenmaker, N., van Veen, K., Vermeij, J., Westendorp, W., Westhoff, D., Zock, E. & Schut, E.
1/12/2010 → …
Project: Research
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Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy
Bus, S. R. M., de Haan, R. J., Vermeulen, M., van Schaik, I. N. & Eftimov, F., 14 Feb 2024, In: Cochrane Database of Systematic Reviews. 2024, 2, CD001797.Research output: Contribution to journal › Review article › Academic › peer-review
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B-cell and T-cell receptor repertoire in chronic inflammatory demyelinating polyneuropathy, a prospective cohort study
van Lieverloo, G. G. A., Al-Soudi, A., Wieske, L., Klarenbeek, P. L., Anang, D. C., Adrichem, M. E., Niewold, I., van Schaik, B. D. C., van Kampen, A. H. C., van Schaik, I. N., de Vries, N. & Eftimov, F., Mar 2023, In: Journal of the peripheral nervous system. 28, 1, p. 69-78 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy
Wieske, L., Michael, M. R., in't Veld, S. G. J. G., Visser, A., van Schaik, I. N., Eftimov, F. & Teunissen, C. E., 2023, (E-pub ahead of print) In: Journal of Neurology, Neurosurgery and Psychiatry. jnnp-2023-332398.Research output: Contribution to journal › Article › Academic › peer-review
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Serum B-cell activating factor is not a potential biomarker for disease activity in chronic inflammatory demyelinating polyneuropathy
Michael, M. R., Wieske, L., Koel-Simmelink, M. J., van Schaik, I. N., Teunissen, C. E. & Eftimov, F., 15 Sept 2023, In: Journal of Neuroimmunology. 382, 578169.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Treatment with add-on IVIg in Myositis Early In the diSease course May be sUperior to Steroids alone for reaching CLinical improvEment (TIME IS MUSCLE): study protocol of a phase-2 double-blind placebo-controlled randomised trial
Kamperman, R. G., Bogaards, J. A., Evers, S. W., Walter, H. A. W., de Visser, M., de Borgie, C., Colen - de Koning, J. C. A., Verhamme, C., Maas, M., Eftimov, F., van Schaik, I. N., van der Kooi, A. J. & Raaphorst, J., 10 Jul 2023, In: BMJ Open. 13, 7, e067435.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus)