Anja A. ten Brinke

(Principal Investigator)

20052023

Research activity per year

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Personal profile

Research interests

My research, at Sanquin, focusses on Immune modulation and Antigen-specific Immunomonitoring, with a specific focus on antigen-specific CD4 T cell and B cell responses.

My group specializes in monitoring the effects of immunomodulatory therapies on the immune system. With a specific focus on the analysis of antigen-specific immune responses, mainly CD4+ T cells and B cells, as the function of these cells is crucial for the efficacy of immunotherapeutic approaches such as vaccinations or tolerizing therapies and pathologies, such as their role in RBC alloimmunization.

I am workpackage leader of the centralized immunomonitoring package of EU H2020 RESTORE (Neuronal self-renewal by antigen-specific tolerization in multiple sclerosis reinstalling the balance between inflammation and regeneration), in which 2 clinical trials are conducted in which tolerogenic dendritic cells are applied to MS patients. Besides we participate currently in the immunomonitoring workpackages of 2 national consortia, Target2B and DC4balance.

Specialisation

Immunomonitoring, Antigen-specific CD4 T cells, B cells, Immune modulation, Autoimmunity

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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