Projects per year
Personal profile
Research interests
Within my research group we explore cellular components that are involved in maintenance of vascular homeostasis. Our research on “Cellular Haemostasis” aims to integrate biochemical and clinical research in the area of thrombosis and hemostasis, vascular biology as well as molecular and cellular immunology. Through this approach we aim to increase our current knowledge on the interactions of hemostatic proteins with the vessel wall as well as the immune system. We expect that studies in this area will result in novel therapeutic approaches for patients with vascular or haematological disorders. Our current focus of research comprises the auto-immune disorder thrombotic thrombocytopenic purpura (TTP). Within the context of an EU funded consortium we are exploring the mechanisms contributing to the onset of autoimmunity in patients with TTP. In parallel we are designing gene therapy and gene correction based strategies for bleeding disorders that include Von Willebrand disease, hemophilia A as well as rare bleeding disorders.
specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biosynthesis and assembly of von Willebrand factor, University of Amsterdam
1 Mar 1987 → 8 Oct 1991
Award Date: 8 Oct 1991
Master, Molecular Sciences, Wageningen University
1 Sept 1980 → 1 Mar 1987
Award Date: 1 Mar 1987
External positions
Principal Investigator, Sanquin-Landsteiner Laboratory AMC: -
1 Jan 2006 → 1 Jan 2030
Keywords
- Q Science (General)
- Cell Biology
- Molecular Biology
- Haemophilia
- bleeding
- hemostasis
Collaborations and top research areas from the last five years
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VWD-TTW: Personalised gene-targeted treatment strategies for the management of the complex genetic bleeding disorder Von Willebrand disease in stratified patient populations
Voorberg, J. & Barraclough, A.
1/10/2021 → 1/10/2025
Project: Research
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EDUC8: Early stage researchers EDUCational program on FVIII immunogenicity
Voorberg, J., Leoni, M. & Mariarosaria, M.
1/10/2020 → 1/10/2026
Project: Research
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SYMPHONY: SYMPHONY; orchestrating personalised treatment for patients with bleeding disorders
1/01/2019 → 1/01/2027
Project: Research
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N-glycan–mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP
Ercig, B., Graça, N. A. G., Kangro, K., Arfman, T., Wichapong, K., Hrdinová, J., Kaijen, P., van Alphen, F. P. J., van den Biggelaar, M., Vanhoorelbeke, K., Veyradier, A., Coppo, P., Reutelingsperger, C., Nicolaes, G. A. F., Männik, A. & Voorberg, J., 13 May 2021, In: Blood. 137, 19, p. 2694-2698 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access10 Citations (Scopus) -
Conformational plasticity of ADAMTS13 in hemostasis and autoimmunity
Ercig, B., Arfman, T., Hrdinova, J., Wichapong, K., Reutelingsperger, C. P. M., Vanhoorelbeke, K., Nicolaes, G. A. F. & Voorberg, J., 1 Oct 2021, In: Journal of Biological Chemistry. 297, 4, 101132.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access4 Citations (Scopus) -
GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies
Kat, M., Burgisser, P. E., Janssen, H., de Cuyper, I. M., Conte, I. L., Hume, A. N., Carter, T., Voorberg, J., Margadant, C. & Bierings, R., 14 Dec 2021, In: Blood. 5, p. 5116-5127 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access10 Citations (Scopus) -
Orchestration of Primary Hemostasis by Platelet and Endothelial Lysosome-Related Organelles
Karampini, E., Bierings, R. & Voorberg, J., 2020, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 40, 6, p. 1441-1453 13 p.Research output: Contribution to journal › Review article › Academic › peer-review
31 Citations (Scopus) -
Tolerating Factor VIII: Recent Progress
Lacroix-Desmazes, S., Voorberg, J., Lillicrap, D., Scott, D. W. & Pratt, K. P., 10 Jan 2020, In: Frontiers in immunology. 10, 2991.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access40 Citations (Scopus)
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Blood (Journal)
Jan J. Voorberg (Reviewer)
2023 → …Activity: Peer review and Editorial work › Publication peer-review
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Emerging concepts in immune TTP
Jan Voorberg (Invited speaker)
19 Jan 2022Activity: Lecture / Presentation › Invited talk › Academic
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PhD defense University of Milan (Event)
Jan Voorberg (Reviewer)
7 Jun 2022Activity: Peer review and Editorial work › Editorial activity
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Loss of Immune Tolerance in Acquired TTP
Jan Voorberg (Invited speaker)
9 Dec 2022Activity: Lecture / Presentation › Invited talk › Academic
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Trombotische trombocytopenische purpura
Jan Voorberg (Invited speaker)
1 Oct 2022Activity: Lecture / Presentation › Invited talk › Academic