Research output per year
Research output per year
Personal profile
Research interests
Intestinal homeostasis. Stem cell biology, tumor genetics, Translational control in the intestine. infections in immunocompromised patients.
specialisation
internal medicine with subspecialisations acute medicine and hematology.
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
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efficacy of plasma derived neutralizing antibodies in immunocompromized patients with COVID-19
Heijmans, J., Rijnders, B. & Kater, A. P.
Project: Research
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Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity
Smit, W. L., Spaan, C. N., de Boer, R. J., Ramesh, P., Garcia, T. N. M., Meijer, B. J., Vermeulen, J. L. M., Lezzerini, M., MacInnes, A. W., Koster, J., Medema, J. P., van den Brink, G. R., Muncan, V. & Heijmans, J., 13 Oct 2020, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117, 41, p. 25560-25570 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access30 Citations (Scopus) -
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
Heijmans, J., van Lidth de Jeude, J. F., Koo, B-K., Rosekrans, S. L., Wielenga, M. C. B., van de Wetering, M., Ferrante, M., Lee, A. S., Onderwater, J. J. M., Paton, J. C., Paton, A. W., Mommaas, A. M., Kodach, L. L., Hardwick, J. C., Hommes, D. W., Clevers, H., Muncan, V. & van den Brink, G. R., 2013, In: Cell reports. 3, 4, p. 1128-1139Research output: Contribution to journal › Article › Academic › peer-review
188 Citations (Scopus) -
Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling
Spaan, C. N., Smit, W. L., van Lidth de Jeude, J. F., Meijer, B. J., Muncan, V., van den Brink, G. R. & Heijmans, J., 2019, In: Cell Death & Disease. 10, 7, 490.Research output: Contribution to journal › Article › Academic › peer-review
Open Access48 Citations (Scopus) -
Heterozygosity of chaperone GRP78 reduces intestinal stem cell regeneration potential and protects against adenoma formation
van Lidth de Jeude, J. F., Spaan, C. N., Meijer, B. J., Smit, W. L., Soeratram, T. T. D., Wielenga, M. C. B., Florien Westendorp, B., Lee, A. S., Meisner, S., Vermeulen, J. L. M., Wildenberg, M. E., van den Brink, G. R., Muncan, V. & Heijmans, J., 2018, In: Cancer research. 78, 21, p. 6098-6106Research output: Contribution to journal › Article › Academic › peer-review
10 Citations (Scopus) -
Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells
van Lidth de Jeude, J. F., Meijer, B. J., Wielenga, M. C. B., Spaan, C. N., Baan, B., Rosekrans, S. L., Meisner, S., Shen, Y. H., Lee, A. S., Paton, J. C., Paton, A. W., Muncan, V., van den Brink, G. R. & Heijmans, J., 2017, In: Oncogene. 36, 24, p. 3397-3405Research output: Contribution to journal › Article › Academic › peer-review
21 Citations (Scopus)