Jeroen Guikema

Research output

Research output per year 1999 2008 2011 2015 2016 2017 2021 2023 2023

• 47 Article
• 11 Comment/Letter to the editor
• 7 Review article
• 1 Chapter
• 1 More
  • 1 Editorial

Research output per year

Research output per year

Search results

• Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins

  van Andel, H., Ren, Z., Koopmans, I., Joosten, S. P. J., Kocemba, K. A., de Lau, W., Kersten, M. J., de Bruin, A. M., Guikema, J. E. J., Clevers, H., Spaargaren, M. & Pals, S. T., 2017, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 114, 2, p. 376-381

  Research output: Contribution to journal › Article › Academic › peer-review

  30 Citations (Scopus)

• Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair

  Schrader, C. E., Guikema, J. E. J., Linehan, E. K., Selsing, E. & Stavnezer, J., 2007, In: Journal of immunology (Baltimore, Md.. 179, 9, p. 6064-6071

  Research output: Contribution to journal › Article › Academic › peer-review
  119 Citations (Scopus)

• Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells

  Staszewski, O., Baker, R. E., Ucher, A. J., Martier, R., Stavnezer, J. & Guikema, J. E. J., 2011, In: Molecular Cell. 41, 2, p. 232-242

  Research output: Contribution to journal › Article › Academic › peer-review
  79 Citations (Scopus)

• AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma

  Bloedjes, T. A., de Wilde, G., Maas, C., Eldering, E., Bende, R. J., van Noesel, C. J. M., Pals, S. T., Spaargaren, M. & Guikema, J. E. J., 8 Sept 2020, In: Blood advances. 4, 17, p. 4151-4164

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  17 Citations (Scopus)

• AKT supports the metabolic fitness of multiple myeloma cells by restricting FOXO activity

  Bloedjes, T. A., de Wilde, G., Khan, G. H., Ashby, T. C., Shaughnessy, J. D., Zhan, F., Houtkooper, R. H., Bende, R. J., van Noesel, C. J. M., Spaargaren, M. & Guikema, J. E. J., 9 May 2023, In: Blood advances. 7, 9, p. 1697-1712 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• A Major Subset of Mutated CLL Expresses Affinity-selected and Functionally Proficient Rheumatoid Factors

  Janssen, J., Donner, N., Li, Z., Wormhoudt, T. A. M., Wagner, K., Guikema, J. E. J., van der Schoot, C. E., Kater, A. P., Feizi, T., Bende, R. J. & van Noesel, C. J. M., 2021, (E-pub ahead of print) In: HemaSphere. e550.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi

  Hoogeboom, R., van Kessel, K. P. M., Hochstenbach, F., Wormhoudt, T. A., Reinten, R. J. A., Wagner, K., Kater, A. P., Guikema, J. E. J., Bende, R. J. & van Noesel, C. J. M., 2013, In: Journal of Experimental Medicine. 210, 1, p. 59-70

  Research output: Contribution to journal › Article › Academic › peer-review
  128 Citations (Scopus)

• A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta

  Pei, D-S., Yang, X-J., Liu, W., Guikema, J. E. J., Schrader, C. E. & Strauss, P. R., 2011, In: Nucleic Acids Research. 39, 8, p. 3156-3165

  Research output: Contribution to journal › Article › Academic › peer-review
  23 Citations (Scopus)

• APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination

  Guikema, J. E. J., Linehan, E. K., Tsuchimoto, D., Nakabeppu, Y., Strauss, P. R., Stavnezer, J. & Schrader, C. E., 2007, In: Journal of Experimental Medicine. 204, 12, p. 3017-3026

  Research output: Contribution to journal › Article › Academic › peer-review
  136 Citations (Scopus)

• Apurinic/Apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge

  Guikema, J. E. J., Gerstein, R. M., Linehan, E. K., Cloherty, E. K., Evan-Browning, E., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., 2011, In: Journal of immunology (Baltimore, Md.. 186, 4, p. 1943-1950

  Research output: Contribution to journal › Article › Academic › peer-review
  25 Citations (Scopus)

• Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells

  Guikema, J. E. J., Linehan, E. K., Esa, N., Tsuchimoto, D., Nakabeppu, Y., Woodland, R. T. & Schrader, C. E., 2014, In: Journal of immunology (Baltimore, Md.. 193, 2, p. 931-939

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)

• ATM Increases Activation-Induced Cytidine Deaminase Activity at Downstream S Regions during Class-Switch Recombination

  Khair, L., Guikema, J. E. J., Linehan, E. K., Ucher, A. J., Leus, N. G. J., Ogilvie, C., Lou, Z., Schrader, C. E. & Stavnezer, J., 2014, In: Journal of immunology (Baltimore, Md.. 192, 10, p. 4887-4896

  Research output: Contribution to journal › Article › Academic › peer-review
  15 Citations (Scopus)

• Autologous stem cell transplantation in multiple myeloma after VAD and EDAP courses: a high incidence of oligoclonal serum Igs post transplantation

  Hovenga, S., de Wolf, J. T., Guikema, J. E., Klip, H., Smit, J. W., Smit Sibinga, C. T., Bos, N. A. & Vellenga, E., 2000, In: Bone marrow transplantation. 25, 7, p. 723-728

  Research output: Contribution to journal › Article › Academic › peer-review
  51 Citations (Scopus)

• B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains

  Slot, L. M., Hoogeboom, R., Smit, L. A., Wormhoudt, T. A. M., Biemond, B. J., Oud, M. E. C. M., Schilder-Tol, E. J. M., Mulder, A. B., Jongejan, A., van Kampen, A. H. C., Kluin, P. M., Guikema, J. E. J., Bende, R. J. & van Noesel, C. J. M., Dec 2016, In: The American Journal of Pathology. 186, 12, p. 3273-3284 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  23 Citations (Scopus)

• CD27 is heterogeneously expressed in multiple myeloma: low CD27 expression in patients with high-risk disease

  Guikema, J. E. J., Hovenga, S., Vellenga, E., Conradie, J. J., Abdulahad, W. H., Bekkema, R., Smit, J. W., Zhan, F., Shaughnessy, J. & Bos, N. A., 2003, In: British journal of haematology. 121, 1, p. 36-43

  Research output: Contribution to journal › Article › Academic › peer-review
  70 Citations (Scopus)

• CD27-triggering on primary plasma cell leukaemia cells has anti-apoptotic effects involving mitogen activated protein kinases

  Guikema, J. E. J., Vellenga, E., Abdulahad, W. H., Hovenga, S. & Bos, N. A., 2004, In: British journal of haematology. 124, 3, p. 299-308

  Research output: Contribution to journal › Article › Academic › peer-review
  25 Citations (Scopus)

• Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model

  Lascano, V., Guadagnoli, M., Schot, J. G., Luijks, D. M., Guikema, J. E. J., Cameron, K., Hahne, M., Pals, S., Slinger, E., Kipps, T. J., van Oers, M. H. J., Eldering, E., Medema, J. P. & Kater, A. P., 2013, In: Blood. 122, 24, p. 3960-3963

  Research output: Contribution to journal › Article › Academic › peer-review
  23 Citations (Scopus)

• Complex biallelic IGH rearrangements in IgM-expressing Z-138 cell line: Involvement of downstream immunoglobulin class switch recombination

  Guikema, J. E. J., Fenton, J. A. L., de Boer, C., Kleiverda, K., Brink, A. A. T. P., Raap, A. K., Estrov, Z., Schuuring, E. & Kluin, P. M., 2005, In: Genes, chromosomes & cancer. 42, 2, p. 164-169

  Research output: Contribution to journal › Article › Academic › peer-review
  8 Citations (Scopus)

• Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing

  Reshetova, P., van Schaik, B. D. C., Klarenbeek, P. L., Doorenspleet, M. E., Esveldt, R. E. E., Tak, P-P., Guikema, J. E. J., de Vries, N. & van Kampen, A. H. C., 2017, In: Frontiers in immunology. 8, p. 221

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)

• Consensus strategy to quantitate malignant cells in myeloma patients is validated in a multicenter study. Belgium-Dutch Hematology-Oncology Group

  Willems, P., Verhagen, O., Segeren, C., Veenhuizen, P., Guikema, J., Wiemer, E., Groothuis, L., Jong, T. B., Kok, H., Bloem, A., Bos, N., Vellenga, E., Mensink, E., Sonneveld, P., Lokhorst, H., van der Schoot, E. & Raymakers, R., 2000, In: Blood. 96, 1, p. 63-70

  Research output: Contribution to journal › Article › Academic › peer-review

  44 Citations (Scopus)

• Convergent evolution and B-cell recirculation in germinal centers in a human lymph node

  Pelissier, A., Stratigopoulou, M., Donner, N., Dimitriadis, E., Bende, R. J., Guikema, J. E., Rodriguez Martinez, M. & van Noesel, C. J., 1 Nov 2023, In: Life Science Alliance. 6, 11, e202301959.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center

  Merino Tejero, E., Lashgari, D., García-Valiente, R., He, J., Robert, P. A., Meyer-Hermann, M., Guikema, J. E. J., Hoefsloot, H. & van Kampen, A. H. C., 17 Aug 2021, In: Frontiers in immunology. 12, 14 p., 716240.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• De novo gene mutations in normal human memory B cells

  Slot, L. M., Wormhoudt, T. A. M., Kwakkenbos, M. J., Wagner, K., Ballering, A., Jongejan, A., van Kampen, A. C. M., Guikema, J. E. J., Bende, R. J. & van Noesel, C. J. M., 2019, In: Leukemia. 33, 5, p. 1219-1230

  Research output: Contribution to journal › Article › Academic › peer-review
  4 Citations (Scopus)

• Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay

  Bahjat, M., Bloedjes, T. A., van der Veen, A., de Wilde, G., Maas, C. & Guikema, J. E. J., 2017, In: Journal of Visualized Experiments. 2017, 124, p. e55703

  Research output: Contribution to journal › Article › Academic › peer-review
  2 Citations (Scopus)

• Exploring the impact of clonal definition on B-cell diversity: implications for the analysis of immune repertoires

  Pelissier, A., Luo, S., Stratigopoulou, M., Guikema, J. E. J. & Rodríguez Martínez, M., 2023, In: Frontiers in immunology. 14, 1123968.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype

  Smit, L. A., Bende, R. J., Aten, J., Guikema, J. E. J., Aarts, W. M. & van Noesel, C. J. M., 2003, In: Cancer research. 63, 14, p. 3894-3898

  Research output: Contribution to journal › Article › Academic › peer-review

  84 Citations (Scopus)

• Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation

  Spanjaard, A., Stratigopoulou, M., de Groot, D., Aslam, M., van den Berk, P. C. M., Stappenbelt, C., Ayidah, M., Catsman, J. J. I., Pardieck, I. N., Kreft, M., Arens, R., Guikema, J. E. J. & Jacobs, H., 9 Jan 2023, In: Frontiers in immunology. 13, 986863.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Scopus)

• IGH switch breakpoints in Burkitt lymphoma: exclusive involvement of noncanonical class switch recombination

  Guikema, J. E. J., de Boer, C., Haralambieva, E., Smit, L. A., van Noesel, C. J. M., Schuuring, E. & Kluin, P. M., 2006, In: Genes, chromosomes & cancer. 45, 9, p. 808-819

  Research output: Contribution to journal › Article › Academic › peer-review
  16 Citations (Scopus)

• Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation

  Thus, Y. J., de Rooij, M. F. M., Swier, N., Beijersbergen, R. L., Guikema, J. E. J., Kersten, M-J., Eldering, E., Pals, S. T., Kater, A. P. & Spaargaren, M., 1 Mar 2023, In: Haematologica. 108, 3, p. 797-810 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  6 Citations (Scopus)

• Interphase fluorescence in situ hybridization for detection of 8q24/MYC breakpoints on routine histologic sections: validation in Burkitt lymphomas from three geographic regions: Validation in Burkitt Lymphomas from Three Geographic Regions

  Haralambieva, E., Schuuring, E., Rosati, S., van Noesel, C., Jansen, P., Appel, I., Guikema, J., Wabinga, H., Bleggi-Torres, L. F., Lam, K., van den Berg, E., Mellink, C., van Zelderen-Bhola, S. & Kluin, P., May 2004, In: Genes, chromosomes & cancer. 40, 1, p. 10-18 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  58 Citations (Scopus)

• Levamisole suppresses activation and proliferation of human T cells by the induction of a p53-dependent DNA damage response

  Khan, G. H., Veltkamp, F., Scheper, M., Hoebe, R. A., Claessen, N., Butter, L., Bouts, A. H. M., Florquin, S. & Guikema, J. E. J., Nov 2023, In: European journal of immunology. 53, 11, 2350562.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Lymphoma-associated mutations in autoreactive memory B cells of patients with Sjögren's syndrome

  Bende, R. J., Slot, L. M., Kwakkenbos, M. J., Wormhoudt, T. A. M., Jongejan, A., Verstappen, G. M., van Kampen, A. C. M., Guikema, J. E. J., Kroese, F. G. M. & van Noesel, C. J. M., Mar 2023, In: Journal of pathology. 259, 3, p. 264-275 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Scopus)

• Mobilized human CD34+ hematopoietic stem cells enhance tumor growth in a nonobese diabetic/severe combined immunodeficient mouse model of human non-Hodgkin's lymphoma

  de Bont, E. S., Guikema, J. E., Scherpen, F., Meeuwsen, T., Kamps, W. A., Vellenga, E. & Bos, N. A., 2001, In: Cancer research. 61, 20, p. 7654-7659

  Research output: Contribution to journal › Article › Academic › peer-review

  55 Citations (Scopus)

• Multiple myeloma related cells in patients undergoing autologous peripheral blood stem cell transplantation

  Guikema, J. E., Vellenga, E., Veeneman, J. M., Hovenga, S., Bakkus, M. H., Klip, H. & Bos, N. A., 1999, In: British journal of haematology. 104, 4, p. 748-754

  Research output: Contribution to journal › Article › Academic › peer-review
  35 Citations (Scopus)

• Myeloma clonotypic B cells are hampered in their ability to undergo B-cell differentiation in vitro

  Guikema, J. E. J., Vellenga, E., Bakkus, M. H. C. & Bos, N. A., 2002, In: British journal of haematology. 119, 1, p. 54-61

  Research output: Contribution to journal › Article › Academic › peer-review
  11 Citations (Scopus)

• NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity

  Ochodnicka-Mackovicova, K., Bahjat, M., Bloedjes, T. A., Maas, C., de Bruin, A. M., Bende, R. J., van Noesel, C. J. M. & Guikema, J. E. J., 2015, In: Blood. 126, 11, p. 1324-1335

  Research output: Contribution to journal › Article › Academic › peer-review
  19 Citations (Scopus)

• p53 represses class switch recombination to IgG2a through its antioxidant function

  Guikema, J. E. J., Schrader, C. E., Brodsky, M. H., Linehan, E. K., Richards, A., El Falaky, N., Li, D. H., Sluss, H. K., Szomolanyi-Tsuda, E. & Stavnezer, J., 2010, In: Journal of immunology (Baltimore, Md.. 184, 11, p. 6177-6187

  Research output: Contribution to journal › Article › Academic › peer-review
  23 Citations (Scopus)

• Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients [research letter]

  Guikema, J. E. J., Rosati, S., Akkermans, K., Bende, R. J., van Noesel, C. J. M., van Krieken, J. H. J. M., Hansmann, M. L., Schuuring, E. & Kluin, P. M., 2005, In: Blood. 105, 7, p. 2997-2998

  Research output: Contribution to journal › Article › Academic › peer-review
  9 Citations (Scopus)

• Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching

  Guikema, J. E. J., Schrader, C. E., Leus, N. G. J., Ucher, A., Linehan, E. K., Werling, U., Edelmann, W. & Stavnezer, J., 2008, In: Journal of immunology (Baltimore, Md.. 181, 12, p. 8450-8459

  Research output: Contribution to journal › Article › Academic › peer-review
  12 Citations (Scopus)

• Salivary Gland Mucosa-Associated Lymphoid Tissue–Type Lymphoma From Sjögren’s Syndrome Patients in the Majority Express Rheumatoid Factors Affinity-Selected for IgG

  Bende, R. J., Janssen, J., Beentjes, A., Wormhoudt, T. A. M., Wagner, K., Haacke, E. A., Kroese, F. G. M., Guikema, J. E. J. & van Noesel, C. J. M., 1 Aug 2020, In: Arthritis & rheumatology (Hoboken, N.J.). 72, 8, p. 1330-1340 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  27 Citations (Scopus)

• SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma

  Leeksma, A. C., Derks, I. A. M., Garrick, B., Jongejan, A., Colombo, M., Bloedjes, T., Trowe, T., Leisten, J. C., Howarth, M., Malek, M., Mortensen, D. S., Blease, K., Groza, M. C., Narla, R. K., Loos, R., Kersten, M-J., Moerland, P. D., Guikema, J. E. J., Kater, A. P., Eldering, E., & 1 othersFilvaroff, E. H., 18 Nov 2022, (E-pub ahead of print) In: Molecular Oncology.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)

• Stereotypic rheumatoid factors that are frequently expressed in mucosa-associated lymphoid tissue-type lymphomas are rare in the labial salivary glands of patients with Sjögren's syndrome

  Bende, R. J., Slot, L. M., Hoogeboom, R., Wormhoudt, T. A. M., Adeoye, A. O., Guikema, J. E. J. & van Noesel, C. J. M., 2015, In: Arthritis & rheumatology (Hoboken, N.J.). 67, 4, p. 1074-1083

  Research output: Contribution to journal › Article › Academic › peer-review
  29 Citations (Scopus)

• Structure and consequences of IGH switch breakpoints in Burkitt lymphoma

  Guikema, J. E. J., Schuuring, E. & Kluin, P. M., 2008, In: Journal of the National Cancer Institute. Monographs. 39, 39, p. 32-36

  Research output: Contribution to journal › Article › Academic › peer-review
  14 Citations (Scopus)

• The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling

  Ochodnicka-Mackovicova, K., Bahjat, M., Maas, C., van der Veen, A., Bloedjes, T. A., de Bruin, A. M., van Andel, H., Schrader, C. E., Hendriks, R. W., Verhoeyen, E., Bende, R. J., van Noesel, C. J. M. & Guikema, J. E. J., 2016, In: Journal of immunology (Baltimore, Md.. 197, 7, p. 2918-2929

  Research output: Contribution to journal › Article › Academic › peer-review
  22 Citations (Scopus)

• The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors

  Bahjat, M., de Wilde, G., van Dam, T., Maas, C., Bloedjes, T., Bende, R. J., van Noesel, C. J. M., Luijks, D. M., Eldering, E., Kersten, M. J. & Guikema, J. E. J., 1 Jan 2019, In: Cell Cycle. 18, 18, p. 2307-2322 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Scopus)

• The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch

  Schrader, C. E., Guikema, J. E. J., Wu, X. & Stavnezer, J., 2009, In: Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 364, 1517, p. 645-652

  Research output: Contribution to journal › Article › Academic › peer-review
  48 Citations (Scopus)

• Understanding repertoire sequencing data through a multiscale computational model of the germinal center

  García-Valiente, R., Merino Tejero, E., Stratigopoulou, M., Balashova, D., Jongejan, A., Lashgari, D., Pélissier, A., Caniels, T. G., Claireaux, M. A. F., Musters, A., van Gils, M. J., Rodríguez Martínez, M., de Vries, N., Meyer-Hermann, M., Guikema, J. E. J., Hoefsloot, H. & van Kampen, A. H. C., 1 Dec 2023, In: npj Systems Biology and Applications. 9, 1, 8.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Scopus)