Projects per year
Personal profile
Research interests
Our research is focused on the role of DNA mutagenic processes in the adaptive immune system and in B-cell malignancies. I have a background in molecular biology and immunology, and my research includes DNA repair, immunoglobulin gene diversification mechanisms and signaling in B cells and B-cell malignancies. My laboratory addresses fundamental questions on DNA damage and repair in B cells and lymphomas, and performs translational research on novel drugs and therapeutic targets for (childhood) leukemia and multiple myeloma. My laboratory is part of the Lymphoma and Myeloma Center Amsterdam (LYMMCARE) consortium.
specialisation
Molecular biology of immunoglobulin gene recombinations
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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van Noesel C.J.M.: B cell biology and the pathogenesis of B-NHL/ The serrated neoplasia pathway to colorectal cancer
Bahjat, M., Bloedjes, T., Donner, D., Janssen, J., Mackovicova, K., Slot, L., van Noesel, C., Guikema, J., Bende, R. & ten Hoonte - Wormhoudt, T.
1/10/2006 → …
Project: Research
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The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling
Ochodnicka-Mackovicova, K., Bahjat, M., Maas, C., van der Veen, A., Bloedjes, T. A., de Bruin, A. M., van Andel, H., Schrader, C. E., Hendriks, R. W., Verhoeyen, E., Bende, R. J., van Noesel, C. J. M. & Guikema, J. E. J., 2016, In: Journal of immunology (Baltimore, Md.. 197, 7, p. 2918-2929Research output: Contribution to journal › Article › Academic › peer-review
22 Citations (Scopus) -
NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity
Ochodnicka-Mackovicova, K., Bahjat, M., Bloedjes, T. A., Maas, C., de Bruin, A. M., Bende, R. J., van Noesel, C. J. M. & Guikema, J. E. J., 2015, In: Blood. 126, 11, p. 1324-1335Research output: Contribution to journal › Article › Academic › peer-review
17 Citations (Scopus) -
Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells
Staszewski, O., Baker, R. E., Ucher, A. J., Martier, R., Stavnezer, J. & Guikema, J. E. J., 2011, In: Molecular Cell. 41, 2, p. 232-242Research output: Contribution to journal › Article › Academic › peer-review
79 Citations (Scopus) -
Mechanism and regulation of class switch recombination
Stavnezer, J., Guikema, J. E. J. & Schrader, C. E., 2008, In: Annual review of immunology. 26, p. 261-292Research output: Contribution to journal › Review article › Academic › peer-review
766 Citations (Scopus) -
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
Guikema, J. E. J., Linehan, E. K., Tsuchimoto, D., Nakabeppu, Y., Strauss, P. R., Stavnezer, J. & Schrader, C. E., 2007, In: Journal of Experimental Medicine. 204, 12, p. 3017-3026Research output: Contribution to journal › Article › Academic › peer-review
136 Citations (Scopus)