Projects per year
Personal profile
specialisation
human immunology, innate immunology, mucosal immunology, epithelial immunology
Research interests
Jochem Bernink – Human Mucosal Immunology
In my lab we aim to contribute to a better understanding how mucosal homeostasis is established, maintained and restored following mechanic damage, irradiation damage or infectious insults in humans.
Towards this aim we develop molecular and cellular tools to dissect interactions between microbiome, mucus, epithelium, and (tissue-resident) immune cells, such as innate lymphoid cells (ILCs).
We will employ humanized immune system mouse models to functionally test our discoveries in vivo, and the physiological relevance of our discoveries is tested in a translational manner through our close collaboration with the department of gastroenterology.
Techniques involved are 2D and 3D organoid cultures, ex vivo cultures, Crispr/cas9 techniques, Flow cytometry, microscopy, etc.
Network
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Projects
- 1 Active
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Spits H.: The biology of human Innate Lymphoid Cells and B cells. Antibodies against tumor antigens
Bartels, L., Gillissen, M., de Jong, G., Krabbendam, L., van Lier, Y., Merat, S., Nagasawa, M., Spits, H., Bal, S., Bernink, J., Fergusson, J. R., Romero Ros, J., Golebski, K. & Shikhagaie, M. M.
1/01/2011 → …
Project: Research
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CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn’s disease
Krabbendam, L., Heesters, B. A., Kradolfer, C. M. A., Haverkate, N. J. E., Becker, M. A. J., Buskens, C. J., Bemelman, W. A., Bernink, J. H. & Spits, H., 1 Dec 2021, In: Nature communications. 12, 1, 5841.Research output: Contribution to journal › Article › Academic › peer-review
Open Access17 Citations (Scopus) -
Identification of human cytotoxic ILC3s
Krabbendam, L., Heesters, B. A., Kradolfer, C. M. A., Spits, H. & Bernink, J. H., Apr 2021, In: European journal of immunology. 51, 4, p. 811-823 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access16 Citations (Scopus) -
Innate lymphoid cells: from helper to killer
Krabbendam, L., Bernink, J. H. & Spits, H., 1 Feb 2021, In: Current opinion in immunology. 68, p. 28-33 6 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access30 Citations (Scopus) -
Interleukin-33 improves local immunity during Gram-negative pneumonia by a combined effect on neutrophils and inflammatory monocytes
Ramirez-Moral, I., Blok, D. C., Bernink, J. H., Garcia-Laorden, M. I., Florquin, S., Boon, L., van't Veer, C., Mack, M., Saluzzo, S., Knapp, S., Spits, H., de Vos, A. F. & van der Poll, T., Apr 2021, In: Journal of pathology. 253, 4, p. 374-383 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access9 Citations (Scopus) -
Author Correction: c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies (Nature Immunology, (2019), 20, 8, (992-1003), 10.1038/s41590-019-0423-0)
Bernink, J. H., Ohne, Y., Teunissen, M. B. M., Wang, J., Wu, J., Krabbendam, L., Guntermann, C., Volckmann, R., Koster, J., van Tol, S., Ramirez, I., Shrestha, Y., de Rie, M. A., Spits, H., Ros, X. R. & Humbles, A. A., 1 Jan 2020, In: Nature immunology. 21, 1, p. 101 1 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open Access1 Citation (Scopus)